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Growth of rheusus cytomegalovirus in macrophages

Growth of rheusus cytomegalovirus in macrophages
恒河猴巨细胞病毒在巨噬细胞中的生长
批准号：
6694843
负责人：
Scott G Hansen
金额：
$4.64万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
项目状态：
已结题
起止时间：
2003-09-01 至 2005-08-31
来源：
https://reporter.nih.gov/project-details/6694843
关键词：
animal tissue artificial chromosomes cytomegalovirus disease /disorder model functional /structural genomics genetic library host organism interaction human immunodeficiency virus macrophage model design /development open reading frames postdoctoral investigator simian immunodeficiency virus transposon /insertion element virus genetics virus replication

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英文摘要
DESCRIPTION (provided by applicant): The purpose of this proposal is to develop rhesus cytomegalovirus (RhCMV) as model system for studying human cytomegalovirus pathogenesis. Specifically, we will be studying the growth determinants of RhCMV in monocyte-derived macrophages (also infected by human immunodeficiency virus or simian immunodeficiency virus), by using a transposon mutagenesis system and bacterial artificial chromosome (BAC) technology.
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Project 2: Characterization of the in vivo T cell (and overall immune) interception of primary SIV infection after vaccination with differentially response programmed RhCMV/SIV vectors
Project 2: Characterization of the in vivo T cell (and overall immune) interception of primary SIV infection after vaccination with differentially response programmed RhCMV/SIV vectors
Understanding Unconventional CD8+ T cell Responses in Protection from HIV
Understanding Unconventional CD8+ T cell Responses in Protection from HIV
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