Growth of rheusus cytomegalovirus in macrophages
Growth of rheusus cytomegalovirus in macrophages
批准号:
6694843
负责人:
Scott G Hansen
金额:
$4.64万
依托单位国家:
美国
项目类别:
财政年份:
2003
资助国家:
美国
项目状态:
已结题
起止时间:
2003-09-01 至 2005-08-31
关键词:
animal tissue artificial chromosomes cytomegalovirus disease /disorder model functional /structural genomics genetic library host organism interaction human immunodeficiency virus macrophage model design /development open reading frames postdoctoral investigator simian immunodeficiency virus transposon /insertion element virus genetics virus replication
中文摘要
描述(由申请方提供):本提案的目的是开发恒河猴巨细胞病毒(RhCMV)作为研究人巨细胞病毒发病机制的模型系统。具体而言,我们将研究的生长决定因素RhCMV单核细胞衍生的巨噬细胞(也感染人类免疫缺陷病毒或猿猴免疫缺陷病毒),通过使用转座子诱变系统和细菌人工染色体(BAC)技术。
英文摘要
DESCRIPTION (provided by applicant): The purpose of this proposal is to develop rhesus cytomegalovirus (RhCMV) as model system for studying human cytomegalovirus pathogenesis. Specifically, we will be studying the growth determinants of RhCMV in monocyte-derived macrophages (also infected by human immunodeficiency virus or simian immunodeficiency virus), by using a transposon mutagenesis system and bacterial artificial chromosome (BAC) technology.
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会议论文
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项目类别:
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资助金额:$75.55万
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财政年份:2022
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负责人:Scott G Hansen
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依托单位:
Project 2: Characterization of the in vivo T cell (and overall immune) interception of primary SIV infection after vaccination with differentially response programmed RhCMV/SIV vectors
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资助金额:$84.72万
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Understanding Unconventional CD8+ T cell Responses in Protection from HIV
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财政年份:2018
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依托单位:
Impact of retroviral infection on non-classical, mycobacteria-specific T cells.
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批准号:9204576
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资助金额:$22.48万
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财政年份:2016
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负责人:Scott G Hansen
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依托单位:
Efficacy of Strain 68-1 RhCMV Vectors Expressing 5' Leader Polypeptides
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批准号:9266296
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资助金额:$85.62万
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财政年份:2016
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Growth of rheusus cytomegalovirus in macrophages
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批准号:6794113
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项目类别:
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资助金额:$4.89万
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财政年份:2003
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负责人:Scott G Hansen
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依托单位:
海外基金