Precision Medicine Research in Nephrology

 描述(由申请者提供)：本项目的目标是培养和培训肾脏病精确医学研究方面的肾病学研究员。在大多数肾病患者中，诊断是基于临床信息，有时是通过肾脏活检。然而，根据临床工具，遗传性和获得性疾病通常无法区分，而且通常情况下，肾功能衰竭的确切病因仍未得到诊断。近年来，基因组、蛋白质组和数据科学的进步使人们能够更准确地描述疾病的分子机制，使人们能够根据主要的分子发病机制重新分类肾脏疾病，有时甚至可以。随着这些先进技术越来越快地被纳入临床实践，它们正在将基础研究与临床研究和日常医学实践联系起来。这些技术有望在慢性肾脏疾病(CKD)患者的护理中产生革命性的影响，因为肾脏疾病经常仅基于临床评估而被诊断，而延迟诊断或错误分类可能会导致在确定疾病病因方面的不确定性。这些进展表明，在肾脏病的精确医学研究中，存在着重大的机会和培养年轻的研究人员。为了实现这一目标，我们汇聚了一批高素质的教职员工，他们带来了跨越精密医学研究全范围的不同专业知识。他们在参与的部门、医学系、生物医学信息学系、转化免疫学中心、病理学系、遗传和发展系、系统生物学系、行为和心血管健康中心、生理学系、生物医学工程系、梅尔曼公共卫生学院流行病学系担任多个职位，都在这一申请中发挥了关键作用。所有的导师都有充足的资金，其中大多数是由美国国立卫生研究院资助的，他们有成功地指导学员在调查中独立职业的记录。该计划将培养肾脏疾病研究领域的下一代研究人员，同时获得多学科专业知识和强大的特定领域知识库，以有效地设计和实施肾脏病研究。

 DESCRIPTION (provided by applicant): The goal of this project is to develop and train Nephrology fellows in Precision Medicine Research for Kidney Diseases. In the majority of patients with kidney disease, the diagnosis is based on clinical information, and sometimes by kidney biopsy. However, genetic and acquired forms of disease are usually indistinguishable based on clinical tools and frequently, the precise etiology of kidney failure remains undiagnosed. In recent years, advances in genomic, proteomic and data sciences have enabled more precise delineation of molecular mechanisms of disease, allowing reclassification of renal disorders based on primary molecular pathogenesis, and sometimes. As these advanced technologies are being incorporated into clinical practice at an increasingly rapid rate, they are bridging basic research with clinical investigations and the daily practice of Medicine. These technologies promises to have transformative effect in the care of patients with Chronic Kidney Disease (CKD), because kidney disorders are frequently diagnosed based on clinical assessment alone, and late diagnosis or misclassification may cause uncertainty in identifying the etiology of disease. These advances indicate that there are major opportunities and for treeing young investigators in precision Medicine Research in Nephrology. To achieve this aim, we brought together participating a high-qualified faculty members, who bring a diverse expertise that span the full spectrum of research in Precision Medicine. They hold multiple appointments in participating departments, the Department of Medicine, The Department of Biomedical Informatics, the Center for Translational Immunology, the Department of Pathology, The Department of Genetics and Development, the Department of Systems Biology, the Center for Behavioral and Cardiovascular Health, the Department of Physiology, the Department of Biomedical Engineering, the Department of Epidemiology in the Mailman School of Public Health, and all play crucial roles in this application. All of the mentors are well funded, the vas majority with NIH funding and have a track record of successfully mentoring trainees to independent careers in investigation. This program will prepare the next generation of investigators in kidney disease research, to simultaneously acquire multidisciplinary expertise and a strong domain- specific knowledgebase to effectively design and implement research within Nephrology.