A Multidisciplinary Conference Centered on Total Knee Arthroplasty Organized by The Knee Society and Other Professional Orthopaedic Organizations

 描述（由申请人提供）：全膝关节置换术（TKA）是一种有效的外科手术，可缓解严重膝关节炎或损伤患者的疼痛。尽管对数期生存率很高，但超过三分之一的TKA患者报告功能改善有限，许多人对结局不满意。关于为什么一些TKA患者获得成功的结果而另一些患者没有，人们知之甚少，强调需要增加研究。拟议会议的目的是将临床医生和科学家聚集在一起，根据他们在改善TKA结果方面的共同兴趣交流想法和策略。会议将重点关注三个领域的研究工作，这些领域最有可能在改善结果和减少与此过程相关的并发症方面取得成果。前两个领域涉及TKA失败的两个常见原因：感染和不稳定。假体周围感染给TKA患者带来了巨大的个人负担，给社会带来了经济负担，威胁到该患者人群的管理。TKA后关节不稳定导致疼痛和患者活动受限，从而导致患者不满。第三个领域涉及使用患者报告的措施来告知TKA的需要和时间并评价TKA结局。患者报告的结局存在显著差异，这些差异强调了在评价TKA影响时从患者获得可靠有效信息的重要性。与会者的多学科小组将负责确定这三个领域的现状，并制定未来研究的途径。会议将围绕所有三个领域的重要问题组织专题介绍，随后进行充分的讨论，从而为与会者之间开展合作创造有利环境。已选择专家就每个问题发言，但所有相关利益攸关方（例如，政府机构、第三方付款人、患者权益维护者和矫形器械制造商）将确保广泛的视角。为了鼓励积极的讨论，每个主题将在分组会议期间在不同的参与者之间进行多次讨论。通过出版关于三个专题中每一个专题的手稿，并强调今后的研究方向，会议所产生的势头将超越会议的时间。会议的结果也将在年会上以及在与会学会和组织的网站上予以强调。TKA研究议程的制定旨在激励个体研究者和多中心合作者进行有影响力的研究，这些研究将直接提高每年接受TKA的数十万美国人的满意度和结局。

 DESCRIPTION (provided by applicant): Total knee arthroplasty (TKA) is an effective surgical procedure for relieving pain in patients with severe knee arthritis or injury. Despite excellent log term survivorship, more than a third of TKA patients report limited functional improvement and many are dissatisfied with their outcomes. Little is known about why some TKA patients achieve a successful outcome while others do not, emphasizing the need for increased research. The purpose of the proposed conference is to bring together clinicians and scientists to exchange ideas and strategies based on their shared interest in improving TKA outcomes. The conference will be focused on research efforts in three areas most likely to bear fruit in improving outcomes and lessening complications that are associated with this procedure. The first two areas involve two common reasons for TKA failure: infection and instability. Periprosthetic infection places an overwhelming personal burden on the TKA patient and an economic burden to society that threatens the management of this patient population. Joint instability after TKA leads to dissatisfaction by causing pain and limiting the patient's activities. The third area deals with th use of patient-reported measures to inform the need for and timing of TKA and to evaluate TKA outcomes. Significant variations exist in patient-reported outcomes, and these variations underscore the importance of obtaining reliable and valid information from patients in evaluating the impact of TKA. The multi-disciplinary group of attendees at the conference will be tasked with establishing the current status of these three areas and with formulating pathways for future research. The conference will create an environment conducive for initiating collaboration among attendees by organizing presentations around important questions in all three areas, followed by ample discussion time. Experts have been chosen to speak to each question, but participation by attendees from all pertinent stakeholders (e.g., government agencies, third party payers, patient advocates, and orthopaedic device manufacturers) will ensure a wide perspective. To encourage active discussion, each topic will be discussed multiple times among different participants during breakout sessions. The momentum gained from the conference will extend beyond the time of the meeting through the publication of manuscripts on each of the three topics with emphasis on future directions for research. The findings of the conference will also be highlighted at the annual meetings and the websites of participating societies and organizations. The development of a research agenda for TKA is intended to stimulate individual investigators and multicenter collaborators to pursue impactful studies that will directy improve the satisfaction and outcomes for the hundreds of thousands of Americans who undergo TKA each year.