A Multidisciplinary Conference Centered on Total Knee Arthroplasty Organized by The Knee Society and Other Professional Orthopaedic Organizations

 描述(由申请人提供)：全膝关节置换术(TKA)是缓解严重膝关节炎或损伤患者疼痛的有效外科手术。尽管存活率很高，但超过三分之一的TKA患者报告说功能改善有限，许多人对他们的结果不满意。对于为什么一些TKA患者取得了成功的结果而另一些患者却没有，人们知之甚少，强调了增加研究的必要性。拟议会议的目的是将临床医生和科学家聚集在一起，基于他们对改善TKA结果的共同兴趣来交流想法和战略。这次会议将集中在三个领域的研究努力，这些领域最有可能在改善结果和减少与这一过程相关的并发症方面取得成果。前两个领域涉及TKA失败的两个常见原因：感染和不稳定。假体周围感染给TKA患者带来了压倒性的个人负担，给社会带来了经济负担，威胁到了对这一患者群体的管理。全膝关节置换术后关节不稳定会引起疼痛和限制患者的活动，从而导致不满。第三个领域涉及患者报告措施的使用，以告知全膝关节置换术的必要性和时机，并评估全膝关节置换术的结果。患者报告的结果存在显著差异，这些差异强调了在评估TKA的影响时从患者那里获得可靠和有效信息的重要性。会议的多学科与会者小组将负责确定这三个领域的现状，并为未来的研究制定途径。会议将通过围绕所有三个领域的重要问题组织演讲，并随后提供充足的讨论时间，为与会者之间的协作创造有利的环境。每个问题都选择了专家发言，但来自所有相关利益攸关方(例如，政府机构、第三方付款人、患者权益倡导者和整形外科设备制造商)的与会者的参与将确保广泛的视角。为了鼓励积极讨论，每个主题将在分组讨论期间在不同的参与者之间多次讨论。通过出版三个专题的手稿，会议获得的势头将延伸到会议时间之外，重点是今后的研究方向。会议的结果也将在年会和参加会议的协会和组织的网站上得到强调。制定TKA的研究议程旨在激励个人研究人员和多中心合作者进行有影响力的研究，这些研究将直接提高每年接受TKA的数十万美国人的满意度和结果。

 DESCRIPTION (provided by applicant): Total knee arthroplasty (TKA) is an effective surgical procedure for relieving pain in patients with severe knee arthritis or injury. Despite excellent log term survivorship, more than a third of TKA patients report limited functional improvement and many are dissatisfied with their outcomes. Little is known about why some TKA patients achieve a successful outcome while others do not, emphasizing the need for increased research. The purpose of the proposed conference is to bring together clinicians and scientists to exchange ideas and strategies based on their shared interest in improving TKA outcomes. The conference will be focused on research efforts in three areas most likely to bear fruit in improving outcomes and lessening complications that are associated with this procedure. The first two areas involve two common reasons for TKA failure: infection and instability. Periprosthetic infection places an overwhelming personal burden on the TKA patient and an economic burden to society that threatens the management of this patient population. Joint instability after TKA leads to dissatisfaction by causing pain and limiting the patient's activities. The third area deals with th use of patient-reported measures to inform the need for and timing of TKA and to evaluate TKA outcomes. Significant variations exist in patient-reported outcomes, and these variations underscore the importance of obtaining reliable and valid information from patients in evaluating the impact of TKA. The multi-disciplinary group of attendees at the conference will be tasked with establishing the current status of these three areas and with formulating pathways for future research. The conference will create an environment conducive for initiating collaboration among attendees by organizing presentations around important questions in all three areas, followed by ample discussion time. Experts have been chosen to speak to each question, but participation by attendees from all pertinent stakeholders (e.g., government agencies, third party payers, patient advocates, and orthopaedic device manufacturers) will ensure a wide perspective. To encourage active discussion, each topic will be discussed multiple times among different participants during breakout sessions. The momentum gained from the conference will extend beyond the time of the meeting through the publication of manuscripts on each of the three topics with emphasis on future directions for research. The findings of the conference will also be highlighted at the annual meetings and the websites of participating societies and organizations. The development of a research agenda for TKA is intended to stimulate individual investigators and multicenter collaborators to pursue impactful studies that will directy improve the satisfaction and outcomes for the hundreds of thousands of Americans who undergo TKA each year.