UT MD Anderson Cancer Center Network Lead Academic Participating Site (LAP)

UT MD 安德森癌症中心网络领导学术参与网站 (LAP)

• 批准号: 9024475
• 负责人: Cathy Eng
• 金额: $ 119.26万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2019-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9024475
• 关键词: Administrator; Adult; Advisory Committees; Authorship; Blood specimen; Cancer Center; Caring; Clinical; Clinical Research; Clinical Trials; Clinical Trials Cooperative Group; Clinical Trials Network; Communication; Data; Data Quality; Development; Diagnostic Imaging; Discipline; Enrollment; Ensure; Faculty; Funding; General Hospitals; Goals; Grant; Group Meetings; Health; Image; Indigent; Institution; Institutional Review Boards; Lead; Leadership; Malignant Neoplasms; Medical Oncology; Mentors; Mentorship; Minority; Mission; National Clinical Trials Network; Operative Surgical Procedures; Participant; Pathology; Patients; Phase; Play; Principal Investigator; Protocols documentation; Publications; Radiation Oncology; Rare Diseases; Reporting; Research Design; Research Personnel; Resolution; Role; Services; Site; Surgical Oncology; Texas; Therapeutic Clinical Trial; Tissues; Training; Translational Research; Underinsured; Uninsured; Work; anticancer research; cancer therapy; education research; experience; faculty research; innovation; member; multidisciplinary; novel; oncology; operation; programs; protocol development; skills; success

DESCRIPTION (provided by applicant): Over the past 8 years, MD Anderson has made significant contributions to cancer clinical cooperative group trials, including robust accrual, scientific and administrative leadership, and mentoring young faculty to participate in and lead these important national trials. These attributes will be applied to the emerging National Clinical Trial Network (NCTN) with even greater emphasis through this Network Lead Academic Participant (LAP) grant, with the following overall aims: Aim 1) To provide robust participation in and accrual to Network group clinical trials targeting a broad range of adult patients with common as well as rare cancers; Aim 2) To promote best practices in the conduct of NCTN-sponsored clinical research and ensure high quality and timely submission of clinical trial-related data and materials as required by specific protocols; Aim 3) To provide scientific and administrative leadership within affiliated Network Groups, including protocol development, publication authorship, participation in Network committees / NCI Central IRB (CIRB), and attendance at Network Group meetings; and Aim 4) To mentor junior faculty, research personnel, and trainees in the leadership, conduct, analysis, and reporting of NCTN and other clinical trials. This LAP utilizes a Multiple Principal Investigator (PI) Plan to apply the demonstrated and complementary cooperative group leadership skills and expertise of 3 investigators: Dr. Cathy Eng, Dr. Kelly Hunt, and Dr. Ritsuko Komaki. In addition, investigators representing the disciplines of pathology, diagnostic imaging, gynecological oncology, surgery, and translational research will play key roles In cooperative group trial conduct and mentorship of young faculty. Oversight of trial accrual and data quality, fund management, centralized communications, and administrative support will be coordinated through the LAP Operations Center under the leadership of an experienced Program Administrator. An Executive Committee will ensure timely inter-Network group communications, effective study prioritizations, review and resolution of any accrual obstacles or data quality issues, and identification of junior facult across the institution as candidates for mentorship and/or leadership roles in Network clinical trials or committees.

描述（由申请人提供）：在过去的8年中，MD安德森为癌症临床合作组试验做出了重大贡献，包括强大的应计，科学和行政领导，并指导年轻教师参与和领导这些重要的国家试验。这些属性将应用于新兴的国家临床 试验网络（NCTN），通过该网络领导学术参与者（NCTN）赠款，具有以下总体目标：目标1）提供强大的参与， 目标2）促进NCTN申办的临床研究的最佳实践，并确保高质量和及时提交临床试验相关的 目标3）在附属网络组内提供科学和行政领导，包括方案开发、出版物作者、参与网络委员会/ NCI中央IRB（CIRB）以及出席网络组会议;和目标4）指导初级教师，研究人员和学员在领导，进行，分析和报告NCTN和其他临床试验。本研究利用多个主要研究者（PI）计划，应用3名研究者（Cathy Eng博士、Kelly Hunt博士和Ritsuko Komaki博士）的示范和互补合作小组领导技能和专业知识。此外，代表病理学，诊断成像，妇科肿瘤学，外科手术和转化研究学科的研究人员将在合作组试验的进行和年轻教师的指导中发挥关键作用。将在一名经验丰富的项目管理员的领导下，通过临床试验运营中心协调对试验累积和数据质量、资金管理、集中通信和行政支持的监督。执行委员会将确保及时的网络间小组沟通，有效的研究优先级，审查和解决任何累积障碍或数据质量问题，并确定整个机构的初级成员作为网络临床试验或委员会的导师和/或领导角色的候选人。