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Health Mechanisms and Outcomes in an Epidemiological Cohort of Vietnam Era Women Veterans

越战时期女性退伍军人流行病学队列的健康机制和结果

基本信息

批准号：
9091026
负责人：
Brian N Smith
金额：
$ 6.95万
依托单位：
BOSTON UNIVERSITY MEDICAL CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-01 至 2018-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9091026
关键词：
Aging Alcohol abuse Alcohol consumption Cohort Studies Data Early-life trauma Elderly Epidemiology Equation Exercise Exposure to Health Health behavior Lead Life Life Stress Link Literature Longitudinal Studies Mediating Mediator of activation protein Mental Depression Mental Health Mental Health Services Military Personnel Modeling Obesity Older Population Outcome Pathway interactions Personal Satisfaction Population Post-Traumatic Stress Disorders Psychosocial Factor Public Health Quality of life Research Resources Risk Risk Behaviors Risk Factors Role Sampling Services Smoking Social support Staging Stress Testing Tobacco use Trauma Veterans Vietnam Woman biological adaptation to stress cohort follow-up functional status health care service health related quality of life healthy aging high risk male men modifiable risk older women physical conditioning post-traumatic stress psychosocial public health relevance stressor tailored health care traumatic event

项目摘要

DESCRIPTION (provided by applicant): Trauma exposure and its mental health correlates - particularly posttraumatic stress disorder (PTSD) - can have negative implications for health-related outcomes, particularly in high-risk populations, such as military and veteran groups. Specific risk mechanisms, however, are understudied in older adults. While there is growing evidence for the association between traumatic stress and physical health, less is known about the role of modifiable psychosocial factors and risk behaviors in the relationships among trauma exposure, stress reactions, and physical health outcomes, including how these risk factors operate over the long term. Examinations of traumatic stress-associated health risk in older, high-risk populations are needed to elucidate potentially modifiable mechanisms by which traumatic stress undermines health-related quality of life and functioning over the long term. Further, to date, the vast majority of research on older veterans has been conducted on men, yet women veterans are the fastest growing group among the veteran population, and they have poorer mental and physical health as compared to their civilian and male veteran counterparts. The proposed research will overcome existing gaps in the literature related to representing women and examining potentially modifiable risk mechanisms in the wake of stress, and will also set the stage for further longitudinal study of risk associations, an important direction in tis research. The focus of the proposed study is to examine the impact of early life traumatic stress exposure and mental health sequelae on later life health in an epidemiological cohort of older women veterans (N=4219) using data from The Health of Vietnam Women's Study (HealthVieWS), which is the most comprehensive study of women Vietnam Era veterans to date. The roles of PTSD and depression will be examined explicitly, as will several potentially modifiable psychosocial factors including salient health-risk behaviors (tobacco use, alcohol abuse, lack of exercise) and perceived social support. The primary health outcomes examined are indicators of health-related quality of life and functional status, obesity, and health conditions. Results will provide valuable pilot data for a larger-scale follow-up with this cohort o investigate hypothesized longitudinal associations linking early life traumatic stress exposure (including military exposure) with health outcomes in later-life, to better understand the long-term impact of military service and early life stress on healthy aging among women veterans.