Approaches for Synthesizing Data in Alcohol Research

酒精研究中的数据综合方法

• 批准号: 9065169
• 负责人: Angela Maria Haeny
• 金额: $ 3.51万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9065169
• 关键词: Alcohol abuse; Alcoholism; Area; Characteristics; Child; Competence; Data; Data Analyses; Data Set; Development; Diagnosis; Diagnostic; Discipline; Disease; Educational workshop; Effect Modifiers (Epidemiology); Environmental Risk Factor; Epidemiology; Family history of; Genetic study; Glass; Goals; Health; Impulsivity; Individual; Insurance Carriers; Knowledge; Literature; Low Prevalence; Measures; Mentors; Meta-Analysis; Methods; Nature; Negative Finding; Parents; Patients; Personality; Personality Traits; Policy Maker; Population; Prevalence; Prevention; Provider; Publishing; Reporting; Research; Research Personnel; Research Training; Risk; Science; Techniques; Training; alcohol research; alcohol use disorder; base; children of alcoholics; conditioning; endophenotype; experience; genetic pedigree; genetics of alcoholism; high risk; improved; insight; interest; intervention program; learning strategy; meetings; multilevel analysis; offspring; parental alcoholism; problem drinker; programs; prospective; psychosocial; skills; study characteristics; trait

 DESCRIPTION (provided by applicant): The broad goal of this proposal is to apply different methods for integrating data to alcohol research. Specifically, meta-analysis and integrative data analysis (IDA) will be used to answer to different research questions relating to the assessment of familial of alcoholism. This objective has implications across disciplines given that these methods can be applied to almost any topic within alcohol research and other fields. Specific Aims The first project, a meta-analysis on children of alcoholics (MOCA), consists of synthesizing the literature to further characterize the relationship between parental alcoholism and traits related to impulsivity in offspring and moderators of this relationship. The goal of MOCA is to identify, specifically, which traits related to impulsivity are associated with having a family history of parental alcoholism. Moderators that will be investigated include study characteristics such as the operationalization of parental alcoholism (e.g., child report of parent's alcohol problems versus assessing parent for alcohol problems). These objectives will be met through the utilization of advanced techniques such as meta-analytic multilevel modeling. The second project, an integrative data analysis of studies assessing lifetime alcohol use disorder (IDA-LAUD), will consist of integrating two data sets with multiple assessments of lifetime alcohol use disorder (AUD). The goal of this project is to further characterize reliabilit problems relating to false negatives in the assessment of lifetime AUD in more representative data sets. Although false negatives are a relatively low base rate phenomenon, the ramifications of its occurrence are severe. Utilizing IDA is the logical next step for further research in this area. Significance The results from MOCA will provide valuable information on the relationship between having a family history of parental alcoholism and impulsivity, which could be used to inform personality- tailored intervention programs. Additionally, the results from IDA-LAUD will provide valuable information on limitations in the assessment of lifetime AUD, which can be used to improve methods for assessing this and other related disorders.

 描述（由申请人提供）：本提案的主要目标是应用不同的方法将数据整合到酒精研究中。具体而言，元分析和综合数据分析（IDA）将被用来回答不同的研究问题，有关评估家庭酗酒。这一目标具有跨学科的影响，因为这些方法可以应用于酒精研究和其他领域的几乎任何主题。具体目标-第一个项目，对酗酒儿童（莫卡）的荟萃分析，包括综合文献，以进一步描述父母酗酒和后代冲动性相关性状之间的关系，以及这种关系的调节剂。莫卡的目标是具体识别哪些与冲动相关的特征与拥有冲动相关 父母酗酒的家族史将被调查的调节因素包括研究特征，如父母酗酒的可操作性（例如，儿童报告父母的酒精问题与评估父母的酒精问题）。这些目标将通过利用先进的技术，如元分析多层次建模来实现。第二个项目是评估终生酒精使用障碍（IDA-LAUD）研究的综合数据分析，将包括将两个数据集与终生酒精使用障碍（AUD）的多个评估相结合。该项目的目标是进一步表征在更具代表性的数据集中评估终生AUD时与假阴性相关的可靠性问题。虽然假阴性是一个相对较低的基本率现象，其发生的后果是严重的。利用IDA是这一领域进一步研究的合理下一步。莫卡的结果将提供有价值的信息，说明父母酗酒家族史与冲动之间的关系，这些信息可用于为个性化干预计划提供信息。此外，IDA-LAUD的结果将提供有关终生AUD评估局限性的有价值信息，这些信息可用于改进评估这种疾病和其他相关疾病的方法。

项目成果

A scoping review and meta-analysis of psychosocial and pharmacological treatments for cannabis and tobacco use among African Americans.

• DOI: 10.1037/adb0000326
• 发表时间: 2017-12
• 期刊: Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors
• 作者: Montgomery L;Robinson C;Seaman EL;Haeny AM
• 通讯作者: Haeny AM