Interdisciplinary Research Network on Early Adversity & Later Life Reversibility

描述（由申请人提供）：拟议研究网络的目标是确定与早期癌症相关的表型的后期可逆性/补救机会。 生活逆境（ELA），汇集了一个由资深和初级科学家组成的国际小组， 促进和推动跨学科研究，以刺激这一领域的迅速发展。该网络将：（a）促进必要的科学知识的增长，这些知识涉及一系列过程和途径，通过这些过程和途径，低社会经济地位[SES]、有压力的经历、不良的亲子关系、孕产妇营养和生活方式）可能对晚年健康和福祉产生类似或不同的影响，以及（B）利用（a）中的证据促进开发和评估新的晚年干预措施，以逆转/降低与ELA相关的风险过程。该网络的具体目标是：（1）。建设能力，以推进跨学科研究，探索ELA带来的风险的中年可逆性或/补偿的潜力，方法是召开一年两次的国际跨学科会议，由具有动物和人类研究专业知识并对合作工作有共同兴趣的研究人员参加，以：（a）促进更好地了解将ELA与晚年健康和福祉轨迹联系起来的生命过程机制/途径;（B）开发和测试晚年干预措施，以减少甚至完全扭转与ELA相关的健康和福祉风险，以及（c）确定推进这一议程的资源需求，并制定发展战略。（二）、通过种子/试点资金支持关于“可逆性/补救”的新研究;（3）.通过提供以下机会将新的研究人员带入该领域： 参与网络活动，包括（a）在试点或其他项目上的合作，（B）作为附属研究人员参加网络会议/讲习班，（c）资助网络研究人员的“实习”;（4）。通过传播和与更广泛的研究界接触，积极开展外联活动：（a）网络网站;（B）在各种专业会议上举办年度网络讲习班或专题讨论会，其中包括对生命过程对早期逆境的影响的学科兴趣，以及（c）出版一份或多份关于生命过程对早期逆境的影响的报告。 关于ELA后期可逆性/补救潜力的文章或特刊，重点关注潜在的生物行为或其他目标以及有希望的干预方法。在实现这些目标时，拟议的网络将（a）大大有助于促进必要的理论和经验工作，以澄清主要的环境影响评估如何影响成年人的健康和福祉，包括解决关于不同生命阶段这些影响的中介者和调节者的未回答的问题，以及（B）支持和促进为中期发展有效干预所需的跨学科合作，以及可以补救/逆转并因此减轻早期生活逆境影响的成年人。

DESCRIPTION (provided by applicant): The goal of the proposed research network will be to identify opportunities for later-life reversibility/remediation of phenotypes associated with early life adversity (ELA) by bringing together an international group of senior and junior scientists to foster and facilitate the interdisciplinary research needed to stimulate rapid advances in this field. The network will: (a) promote needed increases in scientific knowledge regarding the array of processes and pathways through which different ELAs (e.g., low socio-economic status [SES], stressful experiences, poor parent-child relationships, maternal nutrition and lifestyle) may similarly or differentially impact later life health and well-being, and (b) leverage evidence from (a) to promote development and evaluation of novel later-life interventions to reverse/reduce risk processes related to ELAs. Specific aims for this network will be to: (1). Build capacity to advance interdisciplinary research exploring the potential for midlife reversibility of or/compensation for risks conferred by ELA by convening biannual international, interdisciplinary meetings of researchers with expertise spanning animal and human research and a shared interest in collaborative work to: (a) foster better understanding of the life-course mechanisms/pathways linking ELA to trajectories of later life health and well-being; (b) develop and test later-life interventions to reduce or even completely reverse risks to health and well-being associated with ELA, and (c) identify resource needs to advance this agenda and devise strategies for their development. (2). Support new research on "reversibility/remediation" through seed/pilot funding; (3). Bring new researchers into the field by offering opportunities for engagement in network activities, including (a) collaborations on pilot or other projects, (b) participation in network meetings/workshops as affiliated researchers, and (c) funded "internships" with network researchers; and (4). Pursue active out-reach through dissemination and engagement with the broader research community through: (a) a network website; (b) annual network workshops or symposia at various professional meetings that include disciplinary interests in life-course influences on early adversity, and (c) publishing one or more articles or a special issue on the potential for later-life reversibility/remediation for ELA, focued on potential bio-behavioral or other targets and promising intervention approaches. In accomplishing these aims, the proposed network will (a) contribute significantly to promoting needed theoretical and empirical work to clarify how major ELAs impact adult health and well-being, including addressing unanswered questions regarding the mediators and moderators of these influences at different life- stages and (b) support and promote the interdisciplinary collaborations needed to develop effective interventions for mid- and later life adults that can remediate/reverse and therefore to ameliorate effects of early life adversity.