Interdisciplinary Research Network on Early Adversity & Later Life Reversibility

描述(由申请人提供)：拟议的研究网络的目标将是确定与早期疾病相关的表型的后世可逆性/补救机会 生活逆境(ELA)通过召集一个由资深和初级科学家组成的国际小组来 促进和促进所需的跨学科研究，以促进该领域的快速发展。该网络将：(A)促进科学知识的必要增长，了解不同生活方式(如低社会经济地位、有压力的经历、糟糕的亲子关系、产妇营养和生活方式)可能以类似或不同方式影响以后的健康和福祉的各种过程和途径；(B)利用来自(A)的证据，促进制定和评估新颖的生活方式，以逆转/减少与生活方式有关的风险。该网络的具体目标将是：(1)。通过召开一年两次的国际跨学科研究会议，研究人员具有动物和人类研究的专长，并对协作工作有共同兴趣，以促进更好地了解将环境影响与晚年健康和福祉联系起来的生命过程机制/路径；(B)开发和测试晚年干预措施，以减少或甚至完全扭转与环境影响评估相关的健康和福祉风险；(C)确定资源需求，以推进这一议程并为其制定发展战略，从而推动环境影响评估带来的风险或补偿。(2)。通过种子/试点资金支持关于“可逆性/补救”的新研究；通过提供以下机会将新的研究人员带入该领域 参与网络活动，包括(A)就试点或其他项目进行协作，(B)作为附属研究人员参加网络会议/讲习班，以及(C)资助网络研究人员的“实习”；和(4)通过：(A)一个网络网站；(B)在各种专业会议上举办年度网络讲习班或专题讨论会，其中包括对生命过程对早期逆境的影响的学科兴趣；以及(C)出版一本或多本 关于ELA后世可逆性/补救的可能性的文章或特刊，侧重于潜在的生物行为或其他目标和有希望的干预方法。在实现这些目标的过程中，拟议的网络将(A)极大地促进所需的理论和实证工作，以澄清主要的环境影响因素如何影响成人的健康和福祉，包括解决有关这些影响在不同生命阶段的中介和调节因素的悬而未决的问题，以及(B)支持和促进所需的跨学科合作，以便为中老年制定有效的干预措施，以补救/逆转早期生活逆境的影响，从而改善早期生活逆境的影响。

DESCRIPTION (provided by applicant): The goal of the proposed research network will be to identify opportunities for later-life reversibility/remediation of phenotypes associated with early life adversity (ELA) by bringing together an international group of senior and junior scientists to foster and facilitate the interdisciplinary research needed to stimulate rapid advances in this field. The network will: (a) promote needed increases in scientific knowledge regarding the array of processes and pathways through which different ELAs (e.g., low socio-economic status [SES], stressful experiences, poor parent-child relationships, maternal nutrition and lifestyle) may similarly or differentially impact later life health and well-being, and (b) leverage evidence from (a) to promote development and evaluation of novel later-life interventions to reverse/reduce risk processes related to ELAs. Specific aims for this network will be to: (1). Build capacity to advance interdisciplinary research exploring the potential for midlife reversibility of or/compensation for risks conferred by ELA by convening biannual international, interdisciplinary meetings of researchers with expertise spanning animal and human research and a shared interest in collaborative work to: (a) foster better understanding of the life-course mechanisms/pathways linking ELA to trajectories of later life health and well-being; (b) develop and test later-life interventions to reduce or even completely reverse risks to health and well-being associated with ELA, and (c) identify resource needs to advance this agenda and devise strategies for their development. (2). Support new research on "reversibility/remediation" through seed/pilot funding; (3). Bring new researchers into the field by offering opportunities for engagement in network activities, including (a) collaborations on pilot or other projects, (b) participation in network meetings/workshops as affiliated researchers, and (c) funded "internships" with network researchers; and (4). Pursue active out-reach through dissemination and engagement with the broader research community through: (a) a network website; (b) annual network workshops or symposia at various professional meetings that include disciplinary interests in life-course influences on early adversity, and (c) publishing one or more articles or a special issue on the potential for later-life reversibility/remediation for ELA, focued on potential bio-behavioral or other targets and promising intervention approaches. In accomplishing these aims, the proposed network will (a) contribute significantly to promoting needed theoretical and empirical work to clarify how major ELAs impact adult health and well-being, including addressing unanswered questions regarding the mediators and moderators of these influences at different life- stages and (b) support and promote the interdisciplinary collaborations needed to develop effective interventions for mid- and later life adults that can remediate/reverse and therefore to ameliorate effects of early life adversity.