University of Michigan Regional Coordinating Stroke Center

描述（由申请人提供）：密歇根大学区域协调卒中中心（UM RCC）的目的是通过临床试验招募和实施以及卒中研究初级研究者的培训，充分参与NINDS卒中试验网络。UM RCC包括地理位置紧凑的地区的分支机构，UM与该地区有合作历史，并提供访问大量不同的中风患者人群的机会。申请人已经组建了一个专门的多学科研究人员团队，他们在中风临床试验方面经验丰富，并渴望在网络试验中合作，并为所有符合条件的患者提供入组。包括世界级的专家 在中风基础科学谁可以在一个UM RCC和整个网络的领导和培训作出贡献。鉴于UM RCC研究人员在中风相关临床试验方面的专业知识，UM RCC还将预期提出在网络中进行的试验。密歇根大学已经是NINDS资助的神经系统紧急情况治疗试验（NETT）网络的国家临床协调中心（PI：Barsan）的所在地，因此具有网络内临床试验的设计和实施经验。此外，通过NETT，UM拥有执行主临床试验协议和开展需要紧急研究知情同意例外的试验的经验。同样重要的是，在UM RCC中成功进行临床试验，UM卒中项目在发展卒中临床研究人员方面有着良好的记录，因为这是其奖学金项目的主要使命。独特的资源可在UM通过其国家认可的公共卫生学院和罗伯特伍德约翰逊基金会临床学者计划在临床研究的正式教学培训。UM RCC中的学员也将从多学科教师的指导中受益匪浅，这些教师在中风临床试验和临床中风研究方面具有重要的专业知识。

DESCRIPTION (provided by applicant): The purpose of a University of Michigan Regional Coordinating Stroke Center (UM RCC) is to participate fully in the NINDS Stroke Trials Network through clinical trial enrollment and implementation, and the training of junior investigators in stroke research. The UM RCC includes affiliate spokes in a geographically compact region with which UM has a history of collaboration, and provides access to a large and diverse stroke patient population. The applicants have assembled a dedicated multidisciplinary team of investigators who are experienced in stroke clinical trials and anxious to work collaboratively on Network trials and offer enrollment to all eligible patients. Included are also world-class experts in stroke basic science who can contribute to the leadership and training within a UM RCC and the overall network. Given the expertise of the UM RCC investigators in stroke-related clinical trials, a UM RCC would also anticipate proposing trials to be conducted in the Network. The University of Michigan is already home to the NINDS-funded Neurological Emergencies Treatment Trials (NETT) network's national Clinical Coordinating Center (PI: Barsan) and thus has experience with the design and conduct of clinical trials within networks. Furthermore, through the NETT, UM has experience executing master clinical trial agreements and conducting trials that require exception from informed consent for emergency research. Equally as important to the successful conduct of clinical trials within a UM RCC, the UM Stroke Program has a proven track record for developing clinical researchers in stroke, as this is the primary mission of its fellowship program. Unique resources are available at UM for formal didactic training in clinical research through its nationally recognized School of Public Health and its Robert Wood Johnson Foundation Clinical Scholars Program. Trainees within a UM RCC would also benefit tremendously from the mentorship of a multidisciplinary faculty with significant expertise in stroke clinical trials and clinical stroke research.