University of Michigan Regional Coordinating Center (RCC) StrokeNet

密歇根大学区域协调中心 (RCC) StrokeNet

• 批准号: 9983183
• 负责人: DEVIN L BROWN
• 金额: $ 30.88万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9983183
• 关键词: Accident and Emergency department; Adult; Agreement; Applied Research; Area; Basic Science; Blood Vessels; Cause of Death; Childhood stroke; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Design; Clinical Trials Network; Clinical Trials Support Unit; Collaborations; Conduct Clinical Trials; Development; Emergency Care; Emergency Medicine; Enrollment; Faculty; Fellowship Program; Foundations; Funding; Geography; Goals; Health; Home environment; Informed Consent; Infrastructure; Institutes; Lead; Leadership; Mentorship; Michigan; Mission; NCI Scholars Program; National Institute of Neurological Disorders and Stroke; Neurological emergencies; Neurology; Patients; Phase; Phase III Clinical Trials; Physician Executives; Population; Population Heterogeneity; Prevention; Public Health Schools; Recording of previous events; Records; Recovery; Rehabilitation therapy; Research; Research Personnel; Research Training; Resources; Site; Speed; Stroke; Stroke prevention; StrokeNet clinical trials; System; Training; Training Programs; United States National Institutes of Health; Universities; Wood material; care systems; career; career development; clinical trial enrollment; cohesion; data quality; design; disability; experience; innovation; investigator training; multidisciplinary; patient population; pediatric emergency; programs; protocol development; recruit; stroke clinical trials; stroke intervention; stroke patient; stroke trials; success; synergism; treatment trial

The purpose of a University of Michigan Regional Coordinating Stroke Center (UM RCC) is to continue to participate fully in the NIH StrokeNet clinical trials network through clinical trial development, enrollment, and implementation, and the training of early stage investigators in stroke research. The University of Michigan has a long track record of clinical science excellence, expertise in clinical stroke management, excellence in creating stroke systems of care, expertise in stroke clinical trial design and implementation, and a proven ability to recruit subjects. The UM RCC includes affiliate spokes in a geographically focused region with which UM has a history of collaboration, and provides access to a large and diverse stroke patient population. UM has tremendous infrastructure for the conduct of clinical trials including a CTSA-funded Michigan Institute for Clinical & Health Research, and Clinical Trial Support Units, both of which directly benefit the UM RCC. Moreover, the Departments of Emergency Medicine and Neurology at UM are fully supportive of the continuation of a UM RCC. The applicants are part of a dedicated multidisciplinary team of investigators who are experienced in stroke clinical trials and enthusiastic to continue working collaboratively on Network trials and offer enrollment to all eligible patients. Also included are world-class experts in stroke basic science who can continue to contribute to the leadership and training within a UM RCC and the overall network. The UM RCC has proposed and will continue to propose trials for conduct in the Network. One UM RCC proposed clinical trial has been approved for funding. The University of Michigan is already home to the NINDS-funded Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) National Clinical Coordinating Center (PI: Barsan) and its prior incarnation, the Neurological Emergencies Treatment Trials (NETT), and thus has tremendous experience with the design and conduct of clinical trials within networks. Equally as important to the successful conduct of clinical trials within a UM RCC, the UM Stroke Program has a proven track record for developing academic clinical researchers in stroke, as this is the primary mission of its fellowship program. Unique resources are available at UM for formal didactic training in clinical research through its nationally recognized School of Public Health and its Clinician Scholars Program. Trainees within a UM RCC also benefit tremendously from the mentorship of a highly integrated multidisciplinary faculty with significant expertise in stroke clinical trials and clinical stroke research. The initial years of the UM RCC have proven its success in clinical trial enrollment, early investigator training, multi-level network engagement, and clinical trial proposal development.

密歇根大学区域协调中风中心(UM RCC)的目的是继续 全面参与NIH StrokeNet临床试验网络，通过临床试验开发、登记和 实施，以及对中风研究的早期调查人员进行培训。密歇根大学已经 长期的临床科学卓越记录，在临床中风管理方面的专业知识，在 创建卒中护理系统，在卒中临床试验设计和实施方面的专业知识，以及经过验证的 招募受试者的能力。UM RCC包括地理上有重点的地区的分支机构， UM有合作的历史，并提供了接触到大量和多样化的中风患者的机会。恩 拥有进行临床试验的巨大基础设施，包括CTSA资助的密歇根研究所 临床与健康研究和临床试验支持单位，这两个单位都直接使UM RCC受益。 此外，密歇根大学急诊医学和神经内科全力支持 UM RCC的延续。申请者是一个专门的多学科调查团队的一部分，他们 在中风临床试验方面经验丰富，并热衷于继续在网络试验中合作 并向所有符合条件的患者提供登记。还包括世界级的中风基础科学专家 能够继续为UM RCC和整个网络的领导力和培训做出贡献。密歇根大学 RCC已经并将继续提议在该网络中进行试验。建议设立一个UM RCC 临床试验已获准资助。密歇根大学已经是NINDS资助的 创新急救临床试验网络(SIREN)国家临床协调中心的策略 (PI：BARSAN)及其前身神经紧急情况治疗试验(NETT)，因此 在网络内设计和实施临床试验方面有丰富的经验。同样重要的是 在UM RCC内成功进行临床试验，UM卒中计划在以下方面拥有成熟的跟踪记录 培养中风方面的学术临床研究人员，因为这是其奖学金计划的主要使命。 UM提供独特的资源，通过其全国范围内的临床研究进行正式的教学培训 公认的公共卫生学院及其临床医生学者计划。UM RCC内的实习生也受益 来自高度整合的多学科教员的指导，他们在中风临床试验和临床中风研究方面拥有重要的专业知识。UM RCC的最初几年证明了它在以下方面的成功 临床试验招募、早期研究人员培训、多层次网络参与和临床试验方案制定。