University of Arizona - Banner Health Precision Medicine Initiative Cohort Enrollment Center

亚利桑那大学 - 横幅健康精准医学计划队列招生中心

• 批准号: 9228653
• 负责人: Akinlolu Oluseun Ojo
• 金额: $ 395.62万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-06 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9228653
• 关键词: Acute; Alaska; Alaska Native; Ambulatory Care; American Indians; Applications Grants; Arizona; Behavioral; Biomedical Research; Caring; Cessation of life; Clinic; Clinical Trials; Country; Data; Data Collection; Data Set; Development; Disadvantaged; Disease; Disease Management; Dreams; Economics; Effectiveness; Electronic Health Record; Enrollment; Ensure; Ethnic Origin; Ethnic group; Family; Genetic study; Genomics; Goals; Health; Health Personnel; Health Sciences; Health Technology; Healthcare; Hispanics; Hospitals; Individual; Institution; Latino; Lead; Medicine; Minority; Minority Participation; Molecular Genetics; Not Hispanic or Latino; PMI cohort; Participant; Patients; Physicians; Play; Population; Population Group; Prevention approach; Prevention strategy; Primary Health Care; Procedures; Protocols documentation; Race; Recruitment Activity; Research; Research Subjects; Resources; Role; Scientist; Secure; Site; Specimen; Subgroup; System; Technology; Testing; United States National Institutes of Health; Universities; Work; Wyoming; adverse outcome; biobank; cohort; college; design; disability; disorder prevention; ethnic health disparity; ethnic minority population; health disparity; high risk; individualized medicine; meetings; metabolomics; novel; novel therapeutics; precision medicine; premature; programs; racial and ethnic; racial health disparity; racial minority; research study; response; volunteer; working group

ABSTRACT In this grant application, we propose to establish the University of Arizona Health Sciences – Banner Health (UA-Banner) Healthcare Provider Organization (HPO) Enrollment Center for the primary purpose of recruiting the large majority (50-70%) of the American Indians/Alaska Natives (AI/AN) and Hispanics/Latinos (Hisp/Lat) participants required in the NIH Precision Medicine Initiative Cohort Program (PMI-CP) which will initially enroll one million participants. The PMI-CP is a timely development that will facilitate the ability to lever advances in genomics, metabolomics, and health technologies to reduce health disparities which are contributing to excessive suffering, disability, premature death, and economic losses particularly in racial/ethnic minority populations. Today, greater than 20 years after the NIH Revitalization Act, the goal of increasing the participation of minorities in biomedical research remains an unfulfilled dream with participation rates in clinical trials remaining at 0.2% for American Indian/Alaskan Native (AI/AN) and 1-2% for Hisp/Lat; far less than their 1.0% and 17.4% representations in the U.S. population, respectively. Without adequate representation of minorities in research studies, we will continue to practice “Imprecise Medicine” in which research findings from studies conducted almost exclusively in non-Hispanic white populations are extrapolated to racial/ethnic minorities. The UA-Banner proposal is a formal partnership between the University of Arizona and Banner Health serving as the primary healthcare provider for 4.5 million individuals in seven Western States including 60% of the population of Arizona. We will utilize a well-defined potential participant pool of 1.725 million patients across 12 enrollment sites in Arizona, Alaska, and Wyoming to accomplish the following: (1) Enroll >150,000 volunteers, including 7,000 AI/AN, 90,000 Hisp/Lat and 53,000 non-Hispanic Whites, and individuals of other races/ethnicity into the PMI-CP; (2) Implement a comprehensive participant engagement plan that values the participants as “partners in discovery” rather than “research subjects”; (3) Use a secure and robust Enterprise Data Warehouse system to obtain, curate, de-identify, and normalize Electronic Health Records to transmit “core datasets” quarterly to the Coordinating Center (CC) and provide “subgroup” datasets for special studies; and (4) Collaborate with the CC, other HPOs, the participant technologies center, the PMI-CP Biobank, and the Steering Committee to develop and implement protocols and procedures, perform special studies, obtain additional specimens and increase the number and types of data collected. Our targeted enrollment of AI/AN and Hisp/Lat populations into the PMI-CP will bring us closer to one of the President's PMI goals - to reduce ethnic/racial health disparities in the U.S. through the robust participation of the AI/AN and Hisp/Lat populations in PMI-CP special research studies and novel clinical trials as a necessary step to realize the benefits of individualized therapies and tailored preventative strategies in racial/ethnic minority populations.

摘要 在此拨款申请中，我们建议建立亚利桑那大学健康科学-班纳健康 （UA-Banner）医疗保健提供者组织（HPO）招募中心，主要用于招募 绝大多数（50-70%）美国印第安人/阿拉斯加原住民（AI/AN）和西班牙裔/拉丁裔（Hisp/Lat） NIH精准医学倡议队列计划（PMI-CP）所需的参与者，该计划最初将招募 一百万参与者。PMI-CP是一个及时的发展，将促进在以下方面取得进展的能力： 基因组学、代谢组学和健康技术，以减少健康差距， 过度痛苦、残疾、过早死亡和经济损失，特别是在种族/族裔少数群体中 人口。今天，在NIH振兴法案通过20多年后， 少数群体参与生物医学研究仍然是一个未实现的梦想， 美国印第安人/阿拉斯加原住民（AI/AN）的试验保持在0.2%，Hisp/Lat的试验保持在1-2%;远远低于他们的水平。 1.0%和17.4%的代表在美国人口中，分别。如果没有充分的代表性， 在研究中，我们将继续实践“不精确医学”，其中研究结果来自 几乎完全在非西班牙裔白色人群中进行的研究外推至种族/民族 少数群体UA-Banner提案是亚利桑那大学和Banner之间的正式合作伙伴关系 卫生部为西部七个州的450万人提供初级卫生保健服务，包括 亚利桑那州60%的人口。我们将利用一个明确的潜在参与者池172.5万 在亚利桑那州、阿拉斯加州和怀俄明州的12个入组研究中心招募患者，以完成以下任务：（1）入组 > 150，000名志愿者，包括7，000名AI/AN，90，000名Hisp/Lat和53，000名非西班牙裔白人，以及个人 （2）实施全面的参与者参与计划， 将参与者视为“发现的伙伴”而不是“研究对象”;（3）使用安全可靠的 企业数据仓库系统，用于获取、管理、去识别和规范化电子健康记录， 每季度向协调中心传送“核心数据集”，并为特别会议提供“分组”数据集。 研究;以及（4）与CC、其他HPO、参与者技术中心、PMI-CP合作 生物库和指导委员会制定和实施方案和程序， 研究，获得更多的标本，并增加收集的数据的数量和类型。我们的目标 将AI/AN和Hisp/Lat人群纳入PMI-CP将使我们更接近总统的PMI之一 目标-通过AI/AN的积极参与，减少美国的民族/种族健康差距， PMI-CP特殊研究和新型临床试验中的Hisp/Lat人群，作为实现 个体化治疗和量身定制的预防策略在种族/少数民族人群中的益处。