CHRONIC RENAL INSUFFICIENCY COHORT STUDY (CRIC)

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is called the Chronic Renal Insufficiency Cohort Study (CRIC). About 10 million Americans are afflicted with chronic kidney disease (CKD). The individual with CKD may not have any related signs or symptoms but are at risk of developing end stage renal failure and cardiovascular disease (CVD), both of which carries a high burden of debilitating ill-health and premature death. The most affected groups are patients with diabetes mellitus, hypertension and people of African descent. The reasons why some people with CKD develop irreversible kidney failure or why CVD disproportionately affect people with CKD are not known. Therefore, the National Institutes of Diabetes, Digestive and Kidney Disease (NIDDK) has initiated a cohort (observational) clinical study to: (1) identify the risk factors for progression of CKD and (2) identify/understand the relationship between heart disease and kidney failure. In this study, 3,000 adult patients with mild, moderate and severe CKD will be enrolled from seven major clinical sites across the United States. Children are not included in this study because a parallel effort is underway to study similar issues as it affect children. The participants in CRIC will undergo precise measurement of kidney function, detailed serial assessment including medical history, dietary habit and psychosocial profile. They would also undergo multiple tests of various aspects of the cardiovascular system (Echo, EKG, EBCT, ABI, etc.) Some of these tests are designed to identify CVD, CKD and their precipitating factors before overt ill-heath manifest. After enrolment, participants will undergo one annual visit and a brief interval telephone call for a total of five to six years. Half of the participants will be diabetic and one-third will be African Americans to reflect the preponderance of CKD in these population groups. CRIC is described as an observational cohort study because it does not entail the administration of experimental therapies nor does it intervene with current or future medical care of the participants. It is anticipated that the results of the study would form the basis of preventative clinical trials for both CKD and CVD in the future.