CHRONIC RENAL INSUFFICIENCY COHORT STUDY (CRIC)

慢性肾功能不全队列研究 (CRIC)

• 批准号: 7603738
• 负责人: Akinlolu Oluseun Ojo
• 金额: $ 9.69万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603738
• 关键词: Adult; Affect; African; African American; American; Cardiovascular Diseases; Cardiovascular system; Caring; Cessation of life; Child; Chronic Kidney Failure; Chronic Kidney Insufficiency; Clinical Research; Clinical Trials; Cohort Studies; Computer Retrieval of Information on Scientific Projects Database; Diabetes Mellitus; Diet Habits; Electrocardiogram; End stage renal failure; Enrollment; Funding; Future; Grant; Heart Diseases; Hypertension; Individual; Institutes; Institution; Investigational Therapies; Kidney Diseases; Kidney Failure; Measurement; Medical; Medical History; Participant; Patients; Population Group; Precipitating Factors; Renal function; Research; Research Personnel; Resources; Risk; Risk Factors; Source; Symptoms; Telephone; Testing; United States; United States National Institutes of Health; Visit; base; clinical research site; cohort; design; diabetic; psychosocial

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is called the Chronic Renal Insufficiency Cohort Study (CRIC). About 10 million Americans are afflicted with chronic kidney disease (CKD). The individual with CKD may not have any related signs or symptoms but are at risk of developing end stage renal failure and cardiovascular disease (CVD), both of which carries a high burden of debilitating ill-health and premature death. The most affected groups are patients with diabetes mellitus, hypertension and people of African descent. The reasons why some people with CKD develop irreversible kidney failure or why CVD disproportionately affect people with CKD are not known. Therefore, the National Institutes of Diabetes, Digestive and Kidney Disease (NIDDK) has initiated a cohort (observational) clinical study to: (1) identify the risk factors for progression of CKD and (2) identify/understand the relationship between heart disease and kidney failure. In this study, 3,000 adult patients with mild, moderate and severe CKD will be enrolled from seven major clinical sites across the United States. Children are not included in this study because a parallel effort is underway to study similar issues as it affect children. The participants in CRIC will undergo precise measurement of kidney function, detailed serial assessment including medical history, dietary habit and psychosocial profile. They would also undergo multiple tests of various aspects of the cardiovascular system (Echo, EKG, EBCT, ABI, etc.) Some of these tests are designed to identify CVD, CKD and their precipitating factors before overt ill-heath manifest. After enrolment, participants will undergo one annual visit and a brief interval telephone call for a total of five to six years. Half of the participants will be diabetic and one-third will be African Americans to reflect the preponderance of CKD in these population groups. CRIC is described as an observational cohort study because it does not entail the administration of experimental therapies nor does it intervene with current or future medical care of the participants. It is anticipated that the results of the study would form the basis of preventative clinical trials for both CKD and CVD in the future.'

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究被称为慢性肾功能不全队列研究（CRIC）。 大约有1000万美国人患有慢性肾病（CKD）。 CKD患者可能没有任何相关体征或症状，但有发生终末期肾衰竭和心血管疾病（CVD）的风险，这两种疾病都带来了使人衰弱的健康状况不佳和过早死亡的沉重负担。 受影响最大的群体是糖尿病患者、高血压患者和非洲人后裔。 一些CKD患者发生不可逆肾衰竭或CVD不成比例地影响CKD患者的原因尚不清楚。 因此，美国国立糖尿病、消化和肾脏疾病研究所（NIDDK）启动了一项队列（观察性）临床研究，以：（1）确定CKD进展的风险因素和（2）确定/了解心脏病和肾衰竭之间的关系。 在这项研究中，3,000名患有轻度，中度和重度CKD的成年患者将从美国的七个主要临床中心招募。 本研究未包括儿童，因为正在进行一项平行的努力，研究影响儿童的类似问题。 CRIC的参与者将接受精确的肾功能测量，详细的系列评估，包括病史，饮食习惯和心理社会概况。 他们还将接受心血管系统各个方面的多项测试（Echo，EKG，EBCT，ABI等）。 其中一些测试旨在在明显的健康不良表现之前识别CVD，CKD及其诱发因素。 参加者在登记后将接受一次年度访问和一次简短的电话访问，总共五至六年。 一半的参与者将是糖尿病患者，三分之一将是非洲裔美国人，以反映CKD在这些人群中的优势。 CRIC被描述为一项观察性队列研究，因为它不需要实验性治疗，也不干预参与者当前或未来的医疗护理。 预计该研究的结果将成为未来CKD和CVD预防性临床试验的基础。'