NeuroLab M3: Discovery-based explorations of scientific models, model organisms,

NeuroLab M3：基于发现的科学模型、模型生物、

• 批准号: 9107528
• 负责人: Ralph Imondi
• 金额: $ 21.12万
• 依托单位: COASTAL MARINE BIOLABS
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-15 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9107528
• 关键词: Address; American; Animal Model; Applied Research; Area; Award; Axon; Behavior; Biological; Biological Models; Biological Process; Biomedical Research; California; Career Choice; Cellular biology; Collaborations; Communication; Communication Research; Communications Media; Communities; County; Data; Databases; Defect; Development; Developmental Biology; Dimensions; E-learning; Educational Curriculum; Embryonic Development; Exhibits; Fostering; Funding; Future Teacher; Game Based Learning; Goals; Health; Health Sciences; High School Faculty; High School Student; Image; Immersion Investigative Technique; Immunology; Institutes; Institution; Instruction; Internships; Knowledge; Laboratories; Learning; Los Angeles; Memory impairment; Mission; Modeling; Molecular Biology; Nervous system structure; Neurobiology; Neuromuscular Diseases; Neurons; Neurosciences; Neurosciences Research; Next Generation Science Standards; Oceanography; Outcome; Participant; Performance; Population; Process; Public Domains; Research; Research Institute; Resources; Science; Scientist; Series; Societies; Spinal cord injury; Students; Supervision; Teaching Method; Technology; United States National Institutes of Health; Universities; Vision; Visual; Work; base; biomedical scientist; cancer type; career; cell type; comparative; data sharing; education research; educational atmosphere; eleventh grade; evidence base; expectation; experience; follow-up; functional genomics; information framework; innovation; interest; learning progression; lectures; microscopic imaging; model building; nervous system development; neurodevelopment; neuroinformatics; novel; program dissemination; programs; research based learning; research study; skills; success; theories; tool; transgene expression; vision science

DESCRIPTION (provided by applicant): NeuroLab M3 is a comprehensive research education program that carefully guides high school students through an interrelated series of in-depth, interdisciplinary, and discovery-based explorations of scientific models, model organisms, and model systems in developmental neuroscience. Supported by a broad and inclusive professional partnership network consisting of top-flight biomedical research scientists, neuroinformaticians, and educational media and science communication experts, the program delineates a coherent and thoughtfully conceived learning progression that engages students in core scientific practices within and among distinct but interrelated research-based learning environments. Immersive residential research institutes in comparative functional genomics will engage 150 high school students in a complete and integrated scientific workflow that provides novel opportunities for them to expand the repertoire of tools that are currently available for scientists to investigate fundamental aspects of neural development, including neuronal specification and axon pathfinding. Through our collaboration with the Neuroscience Information Framework, a broad-scale neuroinformatics and resource access initiative enabled by the NIH Blueprint, the NeuroLab M3 program also presents new opportunities for students to meaningfully partake in the practices of data sharing, management, annotation, and analytics. More specifically, in addition to generating authentic and novel scientific data that is of practicl value to the biomedical research community, students will disseminate their findings through a public-access image resource database that is jointly maintained by the American Society for Cell Biology and the National Center for Microscopy and Imaging Research. Residential research experiences hosted at our harbor-based learning laboratory will constitute part of a student learning progression that culminates in 8-week university research internships offered through a regional network of biomedical partner laboratories at the University of California (UC), Los Angeles, California Institute of Technology, UC Irvine, Salk Institute for Biological Studies, UC, San Diego, and Scripps Institution of Oceanography. Collectively, these experiences are intended to stimulate and bolster interest in biomedical career pathways, foster realistic career expectations, cultivate an understanding of crosscutting concepts and core scientific practices, and enhance science process skills. A third project component seeks to achieve many of these outcomes by engaging large numbers of teachers and students in the use of an innovative, game-based learning interactive that leads them through the basic to applied research continuum and into visually compelling explorations of the scientific model-building enterprise. Developed in collaboration with NSF award-winning gaming experts, this public-access resource will employ an embedded suite of cutting-edge assessment metrics, data tracking tools, and other analytics to evaluate how students collect, analyze, assimilate, and apply new knowledge to complete interactive missions organized around basic neuroscience research and current models of axon pathfinding.

描述(由申请者提供)：NeuroLab M3是一个全面的研究教育项目，仔细指导高中生在发育神经科学中对科学模型、模型生物体和模型系统进行一系列相互关联的深入、跨学科和基于发现的探索。在由顶尖生物医学研究科学家、神经信息学家、教育媒体和科学传播专家组成的广泛和包容的专业合作伙伴网络的支持下，该计划描绘了一个连贯和深思熟虑的学习进程，使学生在不同但相互关联的研究型学习环境中参与核心科学实践。身临其境的比较功能基因组学住宅研究机构将让150名高中生参与完整和集成的科学工作流程，为他们提供新的机会，以扩大科学家目前可用的工具库，以研究神经发育的基本方面，包括神经元规范和轴突寻径。通过我们与神经科学信息框架的合作，NeuroLab M3项目还为学生提供了新的机会，让他们有意义地参与数据共享、管理、注释和分析的实践。更具体地说，除了产生对生物医学研究社区有实用价值的真实和新颖的科学数据外，学生们还将通过一个公共访问的图像资源数据库传播他们的发现，该数据库由美国细胞生物学学会和国家显微镜和成像研究中心共同维护。在我们的海港学习实验室托管的住宅研究经验将成为学生学习过程的一部分，最终通过加州大学(UC)、洛杉矶、加州理工大学、加州大学欧文分校、索尔克生物研究所、加州大学圣地亚哥分校和斯克里普斯海洋研究所的生物医学合作实验室区域网络提供为期8周的大学研究实习机会。总的来说，这些经验旨在激发和支持对生物医学职业道路的兴趣，培养现实的职业期望，培养对交叉概念和核心科学实践的理解，并提高科学过程技能。项目的第三个组成部分寻求实现这些成果中的许多成果，方法是让大量教师和学生参与创新的、以游戏为基础的学习互动，引导他们从基础研究到应用研究，并在视觉上探索科学模型建设事业。这一公共访问资源是与NSF获奖游戏专家合作开发的，将使用一套嵌入的尖端评估指标、数据跟踪工具和其他分析来评估学生如何收集、分析、吸收和应用新知识，以完成围绕基础神经科学研究和当前轴突寻路模型组织的互动任务。