Research_Project

研究项目

基本信息

项目摘要

RESEARCH PROJECT THE VULNERABLE PRETERM CEREBELLUM: ELUCIDATING MECHANISMS AND CONSEQUENCES OF INJURY Catherine Limperopoulos, Ph.D., Project Director Director, MRI Research of the Developing Brain Director, Advanced Pediatric Brain Imaging Research Laboratory Diagnostic Imaging and Radiology Children’s National Health System Louis-Gilbert Vézina, Ph.D. Director, Pediatric Neuroradiology Children’s National Health System Adre J. du Plessis, MBchB, MPH Chief, Fetal and Transitional Medicine Children National Health System Penny Glass, Ph.D. Director, Child Development Center Center for Neuroscience and Behavioral Medicine Children’s National Health System Lauren Kenworthy, Ph.D. Pediatric Neuropsychologist Director, Center for Autism Spectrum Disorders Children’s National Health System Zungho (Wesley) Zun, Ph.D. MRI Physicist/Research Faculty Advanced Pediatric Brain Imaging Research Laboratory Children’s National Health System Robert J. McCarter Jr., ScD Director of the IDDRC Biostatistics and Informatics Component Head: Research Section of Study Design and Biostatistical Consulting Children’s National Health System Catherine Stoodley, D.Phil. Assistant Professor Psychology and Neuroscience Department American University Abstract Premature birth is a major public health problem, associated with a personal, familial, and societal burden of enormous proportions. The potentially lifelong cognitive, learning and affective-behavioral consequences have become the major determinant of life quality in prematurity survivors, with up to 50% of very premature infants experiencing dysfunction in these domains by school age. Impaired cerebellar development has been recently implicated in this dysfunction. We have described a clinically important, previously under-recognized form of prematurity-related cerebellar parenchymal injury in up to 20% in extremely preterm infants. Recently, our observations have extended beyond the role of parenchymal cerebellar injury to a broader and more prevalent spectrum of cerebellar developmental impairments. We have shown that cerebellar development is (i) markedly accelerated during the third trimester, but (ii) significantly impeded after premature birth, even in the absence of direct cerebellar injury. We refer to this impaired growth as cerebellar developmental impairment (CDI). Complementing this intriguing set of structural observations are our findings of a distinctive long-term neuropsychological profile of cognitive, language, affective and social deficiency, which we have termed the developmental cerebellar cognitive affective disorder. The onset and underlying mechanisms and consequences of prematurity-related CDI remain poorly understood, which in turn have complicated the search for potential therapeutic interventions. We propose to utilize serial, advanced MRI techniques to elucidate the timing, evolution, mechanisms and risk factors of CDI in preterm infants born ≤30 weeks gestational age. Our overarching goal is to identify early MR imaging biomarkers of prematurity-related CDI and the associated clinical factors that lead to specific development disabilities. We plan to leverage our large fetal normative database to compare in-utero fetal and ex-utero preterm cerebellar growth trajectories. These findings will inform specific targets, interventions and timing of future neuroprotective strategies, advance clinical practices, and improve neurodevelopmental outcomes.
研究项目 脆弱的前小脑:机制的探讨和 受伤的后果 Catherine Limperopoulos博士, 项目主任 MRI Research of the Developing Brain(发育中大脑的MRI研究) 高级儿科主任 脑成像研究实验室 诊断成像和放射学 全国儿童保健系统 路易斯-吉尔伯特·韦齐纳博士 儿科神经放射学主任 全国儿童保健系统 Adre J. du Plessis,MBchB,MPH 胎儿和过渡医学主任 儿童国家卫生系统 Penny Glass博士 儿童发展中心主任 神经科学和行为中心 医学 全国儿童保健系统 劳伦·肯沃西博士 儿科神经心理学家 自闭症谱系障碍中心(Center for Autism Spectrum Disorders) 全国儿童保健系统 Zungho(Wesley)Zun,Ph.D. MRI物理学家/研究人员 高级小儿脑成像研究 实验室 全国儿童保健系统 小罗伯特·J·麦卡特,SCD IDDRC生物统计主任 信息学部分 负责人:研究设计和 生物统计咨询 全国儿童保健系统 凯瑟琳·斯杜德利,哲学博士。 助理教授 心理学和神经科学系 美国大学 摘要 早产是一个主要的公共卫生问题,与个人,家庭和社会的负担有关。 巨大的比例。潜在的终身认知,学习和情感行为后果 成为早产儿存活者生活质量的主要决定因素,其中极早产儿的比例高达50% 在这些领域出现功能障碍。小脑发育受损最近 与这种功能障碍有关。我们已经描述了一种临床上重要的,以前认识不足的形式, 在极早产儿中,早产相关的小脑实质损伤高达20%。最近我们 观察结果已经超出了小脑实质损伤的作用, 一系列小脑发育障碍我们已经证明,小脑发育是(i) 在妊娠晚期明显加速,但(ii)在早产后明显受阻,即使在 无直接小脑损伤。我们把这种受损的生长称为小脑发育障碍 (土发委会)。补充这组有趣的结构观察是我们发现的一个独特的长期 认知、语言、情感和社会缺陷的神经心理学特征,我们称之为 发展性小脑认知情感障碍发病和潜在机制, 早产相关CDI的后果仍然知之甚少,这反过来又使研究复杂化 潜在的治疗干预。我们建议利用一系列先进的MRI技术来阐明 胎龄≤30周早产儿CDI发生的时间、演变、机制和危险因素。我们 总体目标是识别早产相关CDI的早期MR成像生物标志物和相关的 导致特定发育障碍的临床因素。我们计划利用我们的大胎儿正常 数据库比较宫内胎儿和子宫外早产儿小脑生长轨迹。这些发现将 告知未来神经保护策略的具体目标、干预措施和时机,先进的临床实践, 并改善神经发育结果。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Catherine Limperopoulos其他文献

Catherine Limperopoulos的其他文献

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{{ truncateString('Catherine Limperopoulos', 18)}}的其他基金

Antecedents of Impaired Brain Development in Fetuses with Heart Disease
患有心脏病的胎儿大脑发育受损的前因
  • 批准号:
    8418213
  • 财政年份:
    2013
  • 资助金额:
    $ 3.03万
  • 项目类别:
Antecedents of Impaired Brain Development in Fetuses with Heart Disease
患有心脏病的胎儿大脑发育受损的前因
  • 批准号:
    8692015
  • 财政年份:
    2013
  • 资助金额:
    $ 3.03万
  • 项目类别:
Antecedents of Impaired Brain Development in Fetuses with Heart Disease
患有心脏病的胎儿大脑发育受损的前因
  • 批准号:
    9242689
  • 财政年份:
    2013
  • 资助金额:
    $ 3.03万
  • 项目类别:
Research_Project
研究项目
  • 批准号:
    9355682
  • 财政年份:
  • 资助金额:
    $ 3.03万
  • 项目类别:
Research_Project
研究项目
  • 批准号:
    9750228
  • 财政年份:
  • 资助金额:
    $ 3.03万
  • 项目类别:

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