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The Electronic Medical Records and Genomics (eMERGE) Network, Phase III

电子病历和基因组学 (eMERGE) 网络，第三阶段

基本信息

批准号：
9134844
负责人：
Gail Pairitz Jarvik
金额：
$ 99.64万
依托单位：
KAISER FOUNDATION HEALTH PLAN OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-01 至 2019-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9134844
关键词：
Address Algorithms Amendment American Asians Blood Cardiovascular Diseases Caring Clinical Collaborations Colon Carcinoma Colorectal Cancer Communication Community Practice Community of Practice Complex Computerized Medical Record Coupled Data Development Disease Disease Resistance Economics Education Effectiveness Electronics Ensure Evaluation Family General Population Genes Genetic Genomic medicine Genomics Goals Health Health system Healthcare Hereditary Disease Herpes zoster disease Immunity Incidental Findings Individual Integrated Delivery Systems Laboratories Leadership Libraries Link Long QT Syndrome Malignant Neoplasms Medical Medical Genetics Methods Mission Modeling Morbidity - disease rate Natural Language Processing Other Genetics Participant Pathogenicity Patient Care Patients Penetrance Pharmacogenetics Phase Phenotype Physicians Policy Developments Population Predisposition Preventive screening Primary Health Care Process Provider Randomized Controlled Trials Reporting Research Design Resources Risk Site Social Impacts Technology Testing Translating Triglycerides Universities Variant Washington Work age related base clinical care clinical practice college cost cost effectiveness design economic cost economic impact economic outcome genetic association genetic variant genome wide association study genomic data improved innovation interest medical specialties mortality neutrophil novel outreach polyposis prevent rare variant screening tool trait

项目摘要

DESCRIPTION (provided by applicant): This application from the Group Health (GH)/University of Washington (UW) eMERGE team proposes specific aims designed to advance integration of genomic data into clinical practice with a focus on clinical discovery and implementation on Mendelian forms of colorectal cancer and/or polyposis (CRC/P) and incidental findings in other actionable genes. Our aims will also allow us to address challenges involved in bringing genomic medicine into standard medical care. Our focus on CRC/P, and quantitative traits and incidental findings (IF) in other actionable genes represents a unique opportunity to move the field forward towards the goal of bringing genomic medicine into effective, standard medical practice in an everyday community practice setting. We have 3 Aims. Aim 1: Genomic medicine discovery and implementation focused on CRC/P, Triglycerides (TG), and neutrophil count (NPC). We proposed sequencing of 1000 CRC and 1000 Asian ancestry participants, to achieve sub- aims of understanding the genetic basis of CRC, TG, and NPC. Aim 2: Integrate genomic information into GH-wide clinical care and the EMR. We will develop intuitive, comprehensive reports to return CRC and other genes deemed actionable by the American College of Medical Genetics and Genomics (ACMG). We will incorporate stakeholder input and then to implement integrated processes and tools into an integrated delivery system with a focus on CRC/P and Long QT syndrome. We will develop and evaluate educational outreach and online resources. Aim 3: Evaluate the effectiveness and economic impact of result return to patients and their families. We will implement a novel tool to increase family communication of CRC genetic results and evaluate the economic impact and cost effectiveness of this tool as well as of returning IFs. Completion of the work in this eMERGE III proposal will guarantee that the Seattle site remains an engaged and effective leader in the eMERGE network in support of NHGRI's mission to ensure that barriers to successful integration of genomic medicine in clinical care are overcome.