MECHANISMS OF HYPERTRIGLYCERIDEMIA IN HUMANS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cholesterol and triglyceride are two fats of interest in blood because they are associated with early coronary artery disease. Triglyceride in blood is carried in very low density lipoproteins (VLDL). The purpose of this study is to determine: 1) the mechanisms of primary hypertriglyceridemia related to VLDL overproduction and/or defective VLDL catabolism related to lipoprotein lipase or hepatic lipase; 2) the interaction of the above with secondary forms of hypertriglyceridemia; and 3) the response of LDL size, composition and mass to changes that occur in VLDL. The study of these subjects will help to understand the pathophysiological mechanisms of each group of disorders of cholesterol and triglyceride metabolism.