Genetic Discovery and Application in a Clinical Setting Continuing a Partnership

描述(由申请人提供)：西雅图Emerge项目旨在通过利用团体健康合作社(GH)广泛的电子病历(EMR)和生物库(包括33年的药房数据库和关于老龄化人口的纵向数据)将个人基因组学应用于实践环境。Emerge I中开发的算法将用于将全基因组关联研究与从EMR挖掘的表型相结合，以发现新的多态-表型关系。目标表型是传染病易感性，特别是对艰难梭菌腹泻、水痘带状疱疹病毒带状疱疹和真菌指甲感染的敏感性，对降压药、5-羟色胺特异性再摄取抑制剂和他汀类药物的反应，包括不良事件。一种新的算法将跟踪纵向血糖和红细胞压积轨迹，一种新的自动化方法将检测核型异常，以评估与骨髓发育不良和白血病的相关性。数据还将支持在其他Emerge站点调查的表型。为了创建一个将基因组学引入临床实践的模型，Emerge I的成功需求评估方法将使利益相关者参与指导临床决策支持格式的EMR用户界面原型的开发。测试案例将是人类白细胞抗原配型，以确定药物不良反应，背景将是GH开发的以患者为中心的医疗家庭护理模式。这项建议为Emerge网络及其合作者提供了西雅图团队在使用自然语言处理(NLP)从EMR提取信息以及帮助采用NLP方法方面的独特专业知识。为了传播Emerge结果并促进合作，它利用调查人员的领导地位，包括Emerge、其他财团和HMO研究网络中的合作伙伴，特别是NIH主任共同基金支持的生物库和巨型流行病学方面的发展潜力。这些目标的完成将揭示新的医学有用的标记，改善高通量基因组方法与EMR数据的联系，并制定政策和实践，将个性化的循证医学带给社区。 相关性(参见说明)：根据个人特征推进个性化药物治疗和预防护理；该项目将DNA与他汀类药物、5-羟色胺特异性再摄取抑制剂(SSRI)和降压药的反应与传染病易感性的微小差异进行匹配。方法将这些结果用于临床护理将由以患者为中心的团体卫生系统中的患者和护理人员的重点小组指导。

DESCRIPTION (provided by applicant): The Seattle eMERGE project aims to bring personal genomics to practice settings by taking advantage of the extensive electronic medical record (EMR) and biorepository of Group Health Cooperative (GH), including a 33-year pharmacy database and longitudinal data on an aging population. Algorithms developed in eMERGE I will be used to combine genome-wide association studies with phenotypes mined from EMRs to discover new polymorphism-phenotype relationships. Target phenotypes are infectious disease susceptibility, specifically to Clostridium difficile diarrhea, shingles from varicella zoster virus, and fungal nail infection, responses to antihypertensive drugs, serotonin-specific reuptake inhibitors, and statins, including adverse events. A new algorithm will follow longitudinal glycemia and hematocrit trajectories, and a novel automated method will detect karyotype abnormalities for assessing correlation to myelodysplasia and leukemia. Data will also support phenotypes investigated at other eMERGE sites. To create a model for introducing genomics into clinical practice, successful needs assessment methods from eMERGE I will engage stakeholders in guiding development of prototype EMR user interfaces in a clinical decision support format. The test case will be human leukocyte antigen-typing for an adverse drug reaction and the setting will be the patient-centered medical home care model developed at GH. This proposal provides the eMERGE network and its collaborators with the Seattle team's unique expertise in using natural language processing (NLP) to extract information from EMRs, and assisting in adoption of NLP methods. To disseminate eMERGE results and foster collaborations, it takes advantage of leadership positions of the investigators, including partners within eMERGE, other consortia and the HMO Research network, especially the potential for developments supported by the NIH Director's Common Fund in biobanking and megaepidemiology. Completion of the aims will reveal new, medically useful markers, improve the linking of high-throughput genomic methods to EMR data, and develop policies and practices for bringing individualized evidence-based medicine to communities. RELEVANCE (See instrucfions): To advance personalized medicine-treatment and preventive care based on individual traits; this project matches small differences in DNA to infectious disease susceptibility and response to statins, serotonin- specific reuptake inhibitors (SSRIs) and blood pressure medications. Methods to use these results in clinical care will be guided by focus groups of patients and caregivers in the patient-centered Group Health system.