System Biology Center in New York

描述(由申请人提供)：纽约系统生物学中心是一个跨学科的中心，它使用系统方法来研究病理生理过程和药物作用。我们是一个高度合作的团队，包括基础和临床研究人员以及来自纽约地区几所大学的教育工作者。中心研究人员在基因组学、生物化学和分子生物学、蛋白质组学、细胞生物学和活细胞信号反应可视化、组织/器官生理学和病理生理学、临床成像和药理学方面拥有专业知识。在计算层面，我们在统计模型、基于图论网络的分析、数学生物学和动态建模方面拥有专业知识，包括常微分方程组、偏微分方程组和随机模型。我们融合了不同学科的专业知识，在不同规模的生物组织中工作，为系统药理学和精确医学等新兴领域做出实质性贡献。在这笔赠款的下一期，我们将以高度整合的方式利用我们的互补专业知识开发和传播方法，以提供对调控网络中的分子相互作用如何导致组织和器官行为的机械性理解，以及如何根据基因组和表观基因组特征来预测新的药物靶点、调整现有药物的用途和预测不良事件。我们的研究活动集中在四个主题项目上，这些项目将整合网络分析和增强的药效学建模，以研究药物对三种疾病的不同方面的作用：胶质母细胞瘤、抑郁症和心力衰竭以及不良事件-周围神经病变。我们的研究活动与我们的教育和外展活动无缝连接，包括与高露洁的教职员工合作，加强面向本科生的系统生物学辅修课程。我们计划提供三门免费的在线系统生物学课程，并为社区大学开发定量生物学课程。我们将与巴西和爱尔兰的系统生物学项目发展新的互动，并继续发展我们为来自不同背景的CUNY学生而举办的非常成功的本科暑期项目，为下一代定量生物医学科学家的培养做好准备。

DESCRIPTION (provided by applicant): Systems Biology Center New York is a trans-disciplinary center that uses systems approaches to study pathophysiological processes and drug action. We are a highly collaborative group of researchers both basic & clinical, and educators from several universities in the New York area. Center investigators have expertise in genomics, biochemistry and molecular biology, proteomics, in cell biology and visualization of signaling reactions live cells, in tissue/organ physiology & pathophysiology, clinical imaging and in pharmacology. At the computational level we have expertise in statistical models, graph-theory network based analyses, mathematical biology and dynamical modeling including ODE, PDE and stochastic models. Melding the expertise of various disciplines we work at various scales of biological organization to make substantive contributions to the emerging fields of systems pharmacology and precision medicine. During the next term of this grant, we will use our complementary expertise in a highly integrated manner to develop and disseminate approaches that provide a mechanistic understanding of how molecular interactions within regulatory networks result in tissue and organ behavior and how this information can be used to predict new drug targets, repurpose existing drugs and predict adverse events in the context of genomic and epigenomic characteristics. Our research activities are focused on four thematic projects that will integrate network analysis and enhanced pharmacodynamic modeling to study different facets of drug action in three diseases: glioblastomas, depression and heart failure and an adverse event-peripheral neuropathy. Our research activities are seamlessly connected to our education and outreach activities that include working with the faculty at Colgate to enhance the Systems Biology Minor program for undergraduates. We plan to offer three free online Systems Biology courses and develop quantitative biology courses for community colleges. We will develop new interactions with Systems Biology Programs in Brazil and Ireland and continue and grow our highly successful undergraduate summer program for CUNY students from diverse backgrounds to prime the pipeline for the next generation of quantitative biomedical scientists.