IGF::OT::IGF SBIR PHASE I TOPIC 352 CELL-BASED MODELS FOR PROSTATE CANCER HEALTH DISPARITY RESEARCH

前列腺癌健康差异研究表明，非裔美国人(AA)男性 患前列腺癌的风险更高，癌症特有的死亡率也更高 与高加索美国人(CA)男性相比。造成差异的原因被归因于 对社会经济差异、环境暴露和生物因素的影响。最大差距 研究一直基于群体，部分原因是缺乏相关的体外和体内模型。 来支持生物学研究。在这个第一阶段的提案中，我们将开发一种注释性AA前列腺 供体与正常前列腺上皮细胞相匹配的上皮癌细胞系 参考前列腺组织。支持建立50个前列腺癌细胞系的可行性 在随后的第二阶段应用中，我们将准备组织的书面方案 条件重编程细胞和试剂的收集、处理、建立 对这些细胞进行研究所必需的。我们将确定其商业可行性。 用于通过公私合作伙伴关系进行细胞分配和试剂营销。

Prostate cancer health disparities studies have shown that African-American (AA) men are at higher risk for developing prostate cancer, as well as at higher risk of cancer specific death rates as compared to Caucasian American (CA) men. The causes of disparities have been attributed to socioeconomic differences, environmental exposures and biological factors. Most disparities studies have been population based, in part, due to the lack of relevant in vitro and in vivo models to support biological studies. In this Phase I proposal, we will develop an annotated AA prostate epithelial cancer cell line with donor matched normal prostate epithelial cells and bio-banked reference prostate tissues. To support the feasibility of establishing 50 prostate cancer cell lines from AA men in a subsequent Phase II application, we will prepare written protocols for tissue collection, processing, establishment of conditionally reprogrammed cells and the reagents necessary for performing studies with these cells. We will determine the commercial feasibility for cell distribution and reagent marketing through a private-public partnership.