ShEEP Request for Faxitron UltraFocus DXA Equipment

在这笔绵羊赠款中，我们申请资金购买UltraFocus双x光吸收测量仪 Faxitron公司安装在肌肉骨骼表型核心的(DXA)仪器 弗吉尼亚州洛玛琳达医疗系统疾病中心(VALLHCS)。UltraFocus DXA 该系统是一个独立的X射线装置和工作站，配有一个10×15厘米的cmos探测器 能量范围为10-100千伏，这使该仪器成为广泛成像的理想仪器 样品的范围以及真正的DXA分析。最高可达6倍的微焦管 几何放大提供高达8微米的图像分辨率。该系统已经过验证 自动计算骨矿密度、骨矿含量以及瘦身和肥胖体 全身和感兴趣区域的质量百分比。这台新仪器 将被VALLHCS的许多研究人员用来进行肌肉骨骼 表型工作。在各种资助研究中提出的研究涉及基因敲除和转基因 需要DXA系统进行常规表型鉴定的小鼠品系。这款软件 随系统一起提供，可自动精确地量化骨密度和 骨矿物质含量。该系统还允许获得用于数据的高质量图像 文件和出版物。退伍军人事务部、国防部和美国国立卫生研究院资助了多名退伍军人事务部的调查人员 医疗中心包括Mohan、Rundle、Qin、Lau、Edderkaoui和Xing博士要求 进行与其资助的赠款申请有关的研究的设备。该系统将取代 大约15年前购买的PIXImus DXA，已无法正常工作更多时间 超过6个月。PIXIMUS仪器是从月球公司购买的， 几年前停止制造或维修这台仪器。我们无法修复 现有的PIXIMUS作为部件或服务不再适用于此仪器。这个 成功完成与以下方面相关的资助研究需要所需的工具 骨质疏松症和骨性关节炎的发病机制和治疗 退伍军人事务部研究任务的领域。

In this ShEEP grant, we request funds to purchase an UltraFocus dual x-ray absorptiometry (DXA) instrument from Faxitron for installation in the phenotype core of Musculoskeletal Disease Center of VA Loma Linda Healthcare System (VALLHCS). The UltraFocus DXA system is a self-contained x-ray unit and workstation with a 10 X 15 cm CMOS detector coupled with the energy range from 10-100 kV that makes this instrument ideal for imaging a broad range of samples as well as for true DXA analysis. The microfocus tube with up to a 6X geometric magnification provides up to 8 µm image resolution. The system has been validated to automatically calculate bone mineral density, bone mineral content, and lean and fat body mass percentages in both the whole body as well as in regions of interest. This new instrument will be used by a number of investigators at the VALLHCS to perform musculoskeletal phenotype work. Studies proposed in various funded studies involve knockout and transgenic mouse strains which will require routine phenotyping by a DXA system. The software that comes with the system allows automated and precise quantitation of bone mineral density and bone mineral content. The system also allows for obtaining high quality images for data documentation and publication. A number of VA, DOD and NIH funded investigators at this VA Medical Center including Drs. Mohan, Rundle, Qin, Lau, Edderkaoui and Xing require this equipment to perform studies related to their funded grant applications. This system will replace a PIXImus DXA that was purchased about 15 years ago and has been non-functional for more than 6 months. The PIXImus instrument was purchased from the Lunar Corporation that stopped manufacturing or servicing this instrument several years ago. We were unable to fix the existing PIXImus as the parts or service is no longer available for this instrument. The requested instrument is needed for successful completion of funded studies that are relevant to the pathogenesis and treatment of osteoporosis and osteoarthritis, diseases that are target areas of the VA research mission.