ShEEP Request for FUJIFILM VisualSonics Vevo 3100 Imaging System

ShEEP 请求 FUJIFILM VisualSonics Vevo 3100 成像系统

• 批准号: 9905989
• 负责人: SUBBURAMAN MOHAN
• 金额: --
• 依托单位: VA LOMA LINDA HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2020-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9905989
• 关键词: Adult; Affect; Aminoglycosides; Animal Experimentation; Animals; Applications Grants; Area; Audiology; Biomedical Research; Body Temperature; Bone callus; Brain; Cells; Cochlea; Data; Data Quality; Defect; Degenerative polyarthritis; Development; Disease; Disease Progression; Electrocardiogram; Embryo; Endothelium; Ephrins; Equipment; Fracture; Frequencies; Funding; Genes; Genetic; Genetic Materials; Grant; Health; Healthcare Systems; Heart; Heart Rate; Heterotopic Ossification; Image; Inflammation; Inflammatory; Injections; Injury; Investigation; Joints; Laboratories; Labyrinth; Left; Life Style; Longitudinal Studies; Measurement; Measures; Medical center; Military Personnel; Minor; Mission; Mole the mammal; Monitor; Morphologic artifacts; Mus; Muscle; Musculoskeletal; Needles; Operative Surgical Procedures; Organ; Oryctolagus cuniculus; Osteoporosis; Pathogenesis; Pharmaceutical Preparations; Phase; Phosphotransferases; Physiologic Monitoring; Physiological; Rattus; Research; Research Personnel; Resolution; Respiration; Services; Sheep; Site; Skeleton; Small Animal Imaging Systems; Synovial Membrane; System; Techniques; Technology; Testing; Therapeutic; Time; Tissues; Transducers; Traumatic Brain Injury; Ultrasonography; United States National Institutes of Health; Universities; Ventricular; Veterans; Work; angiogenesis; articular cartilage; base; bone; chemokine; clinical investigation; cost efficient; data acquisition; design; healing; hearing impairment; high risk; high throughput analysis; image guided; image processing; imaging modality; imaging platform; imaging system; improved; inhibitor/antagonist; instrument; interest; middle ear; mouse model; non-invasive imaging; novel; ototoxicity; pre-clinical; real-time images; response; restoration; round window; service member; skeletal; small molecule; small molecule inhibitor

In this ShEEP grant, we request funds to purchase a high frequency ultrasound imaging system (Vevo 3100) manufactured by FUJIFILMS VisualSonics to specifically image small animals such as mice, rat and rabbits. The ultrasound-based techniques are increasingly being used for pre-clinical investigations. The Vevo 3100 system will be equipped with a linear phased array ultrasound probe specific for small animals and also has several upgrades in the ultrasound technology including; 1) improved resolution, 2) reduced artifact, 3) real time image processing, 4) left ventricular tracing, 5) improved workflow for rapid data acquisition, 6) speckle tracking analysis (for strain analysis), 7) an imaging station equipped with injection mount (for echo guided tissue injections), and 8) a high throughput analysis. This new instrument will be used by a number of investigators at the VALLHCS to perform small animal high frequency ultrasound imaging work. The non-invasive imaging modalities available in the Vevo 3100 system will allow applications that include imaging of soft and hard tissues, monitoring developmental defects in various organs including heart, brain and muscle in mice with targeted disruption of genes of interest, perform measures related to angiogenesis and inflammation, and guided injections of therapeutic moles at sites of interest. The Vevo 3100 system will permit repeated serial measurements in longitudinal studies, thereby permitting more robust statistical assessment and limiting the number of animals needed for the studies. A number of VA, DOD and NIH funded investigators at this VA Medical Center including Drs. Mohan, Lau, Rundle, Dong, Xing, Li and Edderkaoui will benefit from being able to use this equipment to perform studies related to their funded grant applications. Currently, no ultrasound imaging system for small animals is available for research use at VALLHCS. The requested instrument will greatly enhance experimental capabilities of small animal research that are relevant to the pathogenesis and treatment of osteoporosis, osteoarthritis and hearing loss, diseases that are target areas of the VA research mission.

在这笔绵羊赠款中，我们要求资金购买高频超声成像 富士式Visualsonics制造的系统（VEVO 3100）专门图像小图像 小鼠，大鼠和兔子等动物。基于超声的技术越来越多 用于临床前研究。 VEVO 3100系统将配备线性分阶段 阵列超声探针特定于小动物，并且在超声波中也有多次升级 技术包括； 1）改进分辨率，2）减少伪像，3）实时图像处理， 4）左心室跟踪，5）改进了快速数据获取的工作流程，6）斑点跟踪 分析（用于应变分析），7）配备了注入安装的成像站（用于Echo的指导 注射组织）和8）高通量分析。这个新乐器将由数字使用 VALLHC的研究人员进行小动物高频超声成像工作。 VEVO 3100系统中可用的非侵入性成像方式将允许应用 其中包括对软组织的成像，监测各种器官的发育缺陷 包括心脏，大脑和肌肉的小鼠，具有目标破坏感兴趣的基因，执行 与血管生成和炎症有关的措施，并指导注射治疗痣 在感兴趣的遗址。 VEVO 3100系统将允许在 纵向研究，从而允许更强大的统计评估并限制 研究所需的动物数量。许多VA，国防部和NIH资助的调查人员 在这个VA医疗中心，包括Drs。 Mohan，Lau，Rundle，Dong，Xing，Li和Edderkaoui Will 受益于能够使用此设备进行与资助的赠款有关的研究 申请。目前，没有针对小动物的超声成像系统进行研究 在Vallhcs使用。请求的仪器将大大增强 与骨质疏松症的发病机理和治疗有关的小动物研究， 骨关节炎和听力损失，是VA研究任务的目标领域的疾病。