ShEEP Request for FUJIFILM VisualSonics Vevo 3100 Imaging System

在这笔绵羊赠款中，我们申请资金购买高频超声成像 FUJIFILMS Visualsonics制造的系统(Vevo 3100)专门用于拍摄小图像 动物，如老鼠、大鼠和兔子。基于超声波的技术正越来越多地被 用于临床前研究。Vevo 3100系统将配备线性相控 专门针对小动物的阵列超声探头，在超声波方面也有几个升级 技术包括：1)提高分辨率，2)减少伪影，3)实时图像处理， 4)左心室跟踪，5)改进快速数据采集工作流程，6)斑点跟踪 分析(用于应变分析)，7)配备注射装置(用于回波引导)的成像站 组织注射)，以及8)高通量分析。这台新仪器将被许多人使用。 VALLHCS的研究人员在小动物身上进行高频超声成像工作。 Vevo 3100系统中提供的非侵入性成像方式将允许应用 这包括软硬组织的成像，监测各种器官的发育缺陷 包括小鼠的心脏、大脑和肌肉在内的目标基因的靶向破坏，执行 与血管生成和炎症有关的措施，以及治疗性葡萄胎的引导注射 在名胜古迹。Vevo 3100系统将允许重复连续测量 纵向研究，从而允许更可靠的统计评估，并限制 研究所需的动物数量。退伍军人事务部、国防部和美国国立卫生研究院资助的一些调查人员 在这个退伍军人医学中心，包括莫汉、刘、朗德尔、董、邢某、李和埃德尔考伊博士将 受益于能够使用该设备进行与其资助的资助相关的研究 申请。目前，还没有针对小动物的超声成像系统可供研究 在VALLHCS使用。所要求的仪器将极大地增强 与骨质疏松症的发病机制和治疗相关的小动物研究， 骨关节炎和听力损失，这些疾病是退伍军人管理局研究任务的目标领域。

In this ShEEP grant, we request funds to purchase a high frequency ultrasound imaging system (Vevo 3100) manufactured by FUJIFILMS VisualSonics to specifically image small animals such as mice, rat and rabbits. The ultrasound-based techniques are increasingly being used for pre-clinical investigations. The Vevo 3100 system will be equipped with a linear phased array ultrasound probe specific for small animals and also has several upgrades in the ultrasound technology including; 1) improved resolution, 2) reduced artifact, 3) real time image processing, 4) left ventricular tracing, 5) improved workflow for rapid data acquisition, 6) speckle tracking analysis (for strain analysis), 7) an imaging station equipped with injection mount (for echo guided tissue injections), and 8) a high throughput analysis. This new instrument will be used by a number of investigators at the VALLHCS to perform small animal high frequency ultrasound imaging work. The non-invasive imaging modalities available in the Vevo 3100 system will allow applications that include imaging of soft and hard tissues, monitoring developmental defects in various organs including heart, brain and muscle in mice with targeted disruption of genes of interest, perform measures related to angiogenesis and inflammation, and guided injections of therapeutic moles at sites of interest. The Vevo 3100 system will permit repeated serial measurements in longitudinal studies, thereby permitting more robust statistical assessment and limiting the number of animals needed for the studies. A number of VA, DOD and NIH funded investigators at this VA Medical Center including Drs. Mohan, Lau, Rundle, Dong, Xing, Li and Edderkaoui will benefit from being able to use this equipment to perform studies related to their funded grant applications. Currently, no ultrasound imaging system for small animals is available for research use at VALLHCS. The requested instrument will greatly enhance experimental capabilities of small animal research that are relevant to the pathogenesis and treatment of osteoporosis, osteoarthritis and hearing loss, diseases that are target areas of the VA research mission.