Penn mental health AIDS research center

描述（由申请人提供）：宾夕法尼亚大学（Penn）和费城儿童医院（CHOP）拟议的宾夕法尼亚精神健康艾滋病研究中心（PMHARC）的总体主题是通过开发创新的、跨学科的和综合的方法来优化精神病学、行为和医学结果，并更好地了解生物、心理、以及这些综合疾病和治疗背后的行为机制。目前，美国没有其他中心追求这一明确的重点，使PMHARC在NIMH ARC组合中独具一格。大量工作将精神疾病与获得艾滋病毒感染、加速免疫功能障碍、难以获得艾滋病毒护理以及在接受护理后难以坚持抗逆转录病毒治疗联系起来。然而，以证据为基础的干预措施相对缺乏，侧重于精神疾病/艾滋病和相关医学合并症的综合治疗，在确定精神健康治疗与艾滋病毒/艾滋病疾病之间的关系以及了解潜在生物学方面的工作相对较少。PMHARC将为选择研究共病性精神疾病/艾滋病的新老研究者提供指导和资源支持，部分通过创新的试点研究，从而激发解决这些问题的新方法和策略。PMHARC的领导在精神疾病和艾滋病的当代药物治疗、认知行为治疗和基于理论的行为干预方面拥有广泛的专业知识。PMHARC将扩大宾夕法尼亚大学和CHOP之间的良好合作，包括精神病学和宾夕法尼亚大学艾滋病研究中心（CFAR）的合作，以及与费城社区合作伙伴的合作。PMHARC的一个独特之处在于，有知名的精神卫生艾滋病研究人员、以前没有研究过艾滋病的知名精神卫生研究人员、以前没有研究过精神卫生的知名药物滥用艾滋病研究人员以及以前没有关注过精神卫生的艾滋病研究人员的合作。PMHARC将有一个行政和发展核心，以及四个共享资源核心。

DESCRIPTION (provided by applicant): The overarching theme of the proposed Penn Mental Health AIDS Research Center (PMHARC) at the University of Pennsylvania (Penn) and Children's Hospital of Philadelphia (CHOP) is to transform how individuals with comorbid mental illness/AIDS are treated and managed by developing innovative, interdisciplinary, and integrative approaches to optimize psychiatric, behavioral, and medical outcomes and achieving a better understanding of the biological, psychological, and behavioral mechanisms underlying these combined illnesses and treatments. No other center in the U.S. is currently pursuing this explicit focus, making PMHARC unique in the NIMH ARC portfolio. A substantial body of work links psychiatric disorders to acquisition of HIV infection, accelerated immune dysfunction, poor access to HIV care, and poor adherence to antiretroviral treatment once in care. Yet, there is a relative paucity of evidence-based interventions focused on the combined treatment of mental illness/AIDS and related medical co-morbidities, and relatively little work in determining the relationships between mental health treatment and HIV/AIDS disease and understanding the underlying biology. PMHARC will stimulate novel approaches and strategies to address these problems by providing mentoring and resource support for both new and established investigators choosing to study comorbid mental illness/AIDS, in part through innovative pilot studies. PMHARC's leadership has extensive expertise in contemporary pharmacotherapy of mental illness and AIDS, cognitive behavioral treatments, and theory-based behavioral interventions. PMHARC will extend well-established collaborations at Penn and CHOP, including those in the Department of Psychiatry and Penn Center for AIDS Research (CFAR), as well as with community partners in Philadelphia. A unique feature of PMHARC is the collaboration of well-established mental health AIDS researchers, well-established mental health researchers who have not previously studied AIDS, well-established substance abuse AIDS researchers who have not previously studied mental health, and AIDS researchers not previously focused on mental health. PMHARC will have an Administrative and Developmental Core, and four Shared Resource Cores.