Clinical Recovery and Repair Core (CRRC)

临床恢复和修复核心 (CRRC)

• 批准号: 9144413
• 负责人: Richard Campbell
• 金额: $ 25.83万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9144413
• 关键词: Acute; Acute Brain Injuries; Address; Adopted; Advocate; Affect; Animals; Award; Basic Science; Behavior Therapy; Behavioral; Biological Markers; Brain; Brain Injuries; Cause of Death; Centers of Research Excellence; Clinical; Clinical Research; Clinical Treatment; Cognitive; Communities; Consultations; Core Facility; Data Analyses; Data Collection; Disease; Education; Educational workshop; Electroencephalography; Emotional; Ensure; Equipment; Evaluation; Extramural Activities; Family; Fee-for-Service Plans; Fostering; Funding; Future; Goals; Health; Human Resources; Individual; Injury; Interdisciplinary Study; Intervention; Intervention Studies; Knowledge; Lead; Leadership; Life; Mentors; Neurobiology; Neurosciences; New Mexico; Outcome; Outcome Measure; Patient Outcomes Assessments; Patients; Physiological; Pilot Projects; Psychometrics; Public Health; Quality of life; Recovery; Research; Research Design; Research Personnel; Research Project Grants; Resources; Stroke; Survivors; Training; Translating; Trauma; Treatment Efficacy; United States National Institutes of Health; Universities; base; bench to bedside; brain repair; clinical investigation; cost; disability; equipment training; human subject; improved; improved outcome; innovation; instrumentation; interdisciplinary collaboration; meetings; member; motor deficit; neuropsychological; novel; patient population; pre-clinical; programs; repaired; research and development; research clinical testing; skills; social; success; therapy development; training opportunity

SUMMARY Brain injury and stroke are leading causes of death and disability in New Mexico. Given the associated significant public health consequences with these conditions, it is critical that we advance our understanding of brain recovery and repair and develop novel interventions to improve the outcome and quality of life of affected individuals and their families, as well as reduce the costs associated with these conditions. Evaluating new clinical treatments requires interdisciplinary collaborations between preclinical and clinical researchers, each with unique skill sets and knowledge necessary to move new interventions from bench to bedside. Promising clinical neuroscience investigators often require training, mentoring, and consultation in the requisite skills of research design, subject recruitment strategies, selection and administration of appropriate outcome measures, psychometric analyses as well as access to state-of-the-art neuropsychological assessment resources to evaluate interventions and predict outcome. The long-term goal of the Clinical Core is to develop a consolidated clinical intervention research facility that provides leadership, mentoring/guidance, and training for young investigators focusing on brain recovery and repair, and is a research hub that fosters vibrant, interdisciplinary collaborations and supports a critical mass of investigators focused on brain recovery and repair. The Core will pursue the following aims: 1) Develop a centralized clinical research core to support interdisciplinary studies of recovery from acute brain injury, by providing expertise, training, and state-of-the-art equipment for clinical studies of interventions and mechanisms of recovery from acute brain injury. 2) Support current and future Junior PI research projects that concentrate on brain injury and repair with training, consultation and guidance in research design, neuropsychological assessment, data collection and analysis so that they may realize extramural funding.3) Develop a user base of established, funded investigators from within the UNM research community as well as non-UNM investigators to ensure sustainability of Clinical Core to support clinical research that is focused on improving the outcome from brain injury. Together with the Preclinical Core, we will support the goals of the COBRE Center by providing an sustainable, state-of-the-art resource which will provide expertise, training and instrumentation for COBRE PIs and other investigators to accelerate discovery of new treatments for brain injury survivors.

总结 脑损伤和中风是新墨西哥州死亡和残疾的主要原因。鉴于相关的 严重的公共卫生后果与这些条件，这是至关重要的，我们推进我们的理解， 脑恢复和修复，并开发新的干预措施，以改善受影响的结果和生活质量 这将有助于个人及其家庭，并降低与这些疾病相关的费用。评估新 临床治疗需要临床前和临床研究人员之间的跨学科合作， 他们拥有将新的干预措施从实验室推广到临床所需的独特技能和知识。有前途 临床神经科学研究人员通常需要必要技能的培训、指导和咨询 研究设计、受试者招募策略、适当结果的选择和管理 测量、心理测量分析以及获得最先进的神经心理评估 评估干预措施和预测结果的资源。临床核心的长期目标是开发 一个综合的临床干预研究机构，提供领导、指导/指导和培训 为年轻的研究人员专注于大脑恢复和修复，是一个研究中心，培养充满活力， 跨学科的合作，并支持一个关键质量的研究人员专注于大脑恢复， 修复.核心将追求以下目标：1）发展一个集中的临床研究核心，以支持 急性脑损伤恢复的跨学科研究，通过提供专业知识，培训和最先进的 急性脑损伤干预和恢复机制的临床研究设备。2)支持 目前和未来的初级PI研究项目，专注于脑损伤和修复与培训， 研究设计、神经心理学评估、数据收集和分析等方面的咨询和指导， 3）建立一个用户基础，由来自以下方面的已建立的、受资助的调查人员组成： 在UNM研究界以及非UNM研究者，以确保临床核心的可持续性 以支持临床研究，重点是改善脑损伤的结果。连同 临床前核心，我们将通过提供可持续的，最先进的 将为COBRE PI和其他研究者提供专业知识、培训和仪器的资源， 加速发现脑损伤幸存者的新疗法。