Research Program: Global Oncology

全球肿瘤学课程 项目概要/摘要 癌症越来越被认为是对全世界人民健康的威胁。当前的估计表明来自 到2020年，70%的新发癌症病例将发生在低收入和中等收入国家。这些统计数据的驱动因素 包括由于总体健康而延长寿命和减少儿童和成人死亡率; 肥胖症;吸烟率较高;在非洲，癌症发病率上升与越来越多的 艾滋病毒的长期幸存者。这些趋势可能会继续下去。癌症死亡率也较高， 资源贫乏的经济体。 全球肿瘤学计划（PiGO）的目标是制定一个强大的研究计划，允许在- 国家调查人员制定数据驱动的方法，以预防和治疗癌症， 在其区域的相关性，以及发展一个强大的研究企业，利用资源和 在这些国家的机会，以增加我们对癌症的了解，特别是那些罕见的， 在发达国家和发展中国家很常见。在美国以外进行的研究已经阐明了 新的癌症风险因素，描述了常见恶性肿瘤的独特分子特征，并建议 癌症预防和治疗的潜在新策略。PiGO利用我们的癌症资源 该中心通过四个具体目标在美国以外领导有效的研究：1）利用数据系统， 方法和可视化，以支持全球癌症监测; 2）扩大我们对艾滋病毒引起的肿瘤的研究- 感染和非艾滋病毒感染的个体，以确定如何以及是否这些癌症的不同，利用 我们在乌干达、南非和中国某些地区发展了人力和物质基础设施; 3） 进一步发展强大的多学科研究计划，以发现新的感染相关癌症， 特别强调艾滋病毒感染者; 4）制定有效的国内指导方针， 检测、潜在预防和治疗资源匮乏环境中常见的癌症。 PiGO有35名成员，来自3所学校和FHCRC、UW和儿童的18个部门， 在2013财政年度的同行评审资金（直接美元）中，其中260万美元（49%）来自NCI。程序 还有来自比尔和梅林达盖茨基金会的2140万美元（癌症相关部分）。议员 发表了322篇论文，其中10%是程序内的，33%是程序内的，18%是跨程序的。 体制性的。

Program in Global Oncology Project Summary/Abstract Cancer is increasingly recognized as a threat to the health of people worldwide. Current estimates are that 70% of new cancer cases will be in low- and middle-income countries by 2020. Drivers of these statistics include increasing life spans due to overall health and reductions in childhood and adult mortality; increasing obesity; higher smoking rates; and, in Africa, increasing rates of cancer associated with the growing number of long-term survivors of HIV. These trends are likely to continue. Cancer mortality rates are also higher in resource-poor economies. The goal of the Program in Global Oncology (PiGO) is to develop a robust research program that allows in- country investigators to develop data-driven approaches to the prevention and treatment of cancers of relevance in their region, as well as to develop a robust research enterprise that leverages the resources and opportunities in these countries to increase our understanding of cancer, especially those that are rare in the developed world and common in the developing world. Research conducted outside the U.S. has elucidated novel cancer risk factors, described unique molecular signatures for common malignancies, and suggested potential new strategies for cancer prevention and treatment. PiGO leverages the resources of our Cancer Center to lead effective research outside the U.S. through four Specific Aims: 1) Leverage data systems, methods and visualization to support global surveillance of cancer; 2) Expand our studies of tumors from HIV- infected and non-HIV-infected individuals to determine how and whether these cancers differ, utilizing the human and physical infrastructure we have developed in Uganda, South Africa and select areas in China; 3) Further develop a robust multidisciplinary research program to discover novel infection-related cancers, with particular emphasis on HIV-infected individuals; and 4) Develop effective in-country guidelines to improve the detection, potential prevention and treatment of common cancers found in resource poor settings. PiGO has 35 members drawn from 3 schools and 18 departments of FHCRC, UW and Children's, and $4.5M in peer-reviewed funding (direct dollars) in fiscal year 2013, of which $2.6M (49%) is from NCI. The program also has $ 21.4M (cancer-relevant portion) from the Bill and Melinda Gates Foundation. Members have published 322 papers, of which 10% are intra-programmatic, 33% are intra-programmatic and 18% are inter- institutional.