Expanding independent research capacity in HIV-associated malignancies in Uganda

扩大乌干达艾滋病毒相关恶性肿瘤的独立研究能力

• 批准号: 8708481
• 负责人: Corey Casper
• 金额: $ 30.46万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8708481
• 关键词: Acquired Immunodeficiency Syndrome; Area; Award; Carcinogens; Caring; Cause of Death; Clinical; Country; Doctor' s Degree; Fred Hutchinson Cancer Research Center; Grant; HIV; HIV Infections; HIV Seropositivity; HIV diagnosis; Health; High Prevalence; Hybrids; Incidence; Individual; Institutes; Interview; Kaposi Sarcoma; Life; Malignant Neoplasms; Malignant neoplasm of anus; Malignant neoplasm of cervix uteri; Malignant neoplasm of lung; Measures; Mentors; Non-Hodgkin' s Lymphoma; Operations Research; Persons; Primary carcinoma of the liver cells; Research; Research Project Grants; Resources; Scientist; Structure; Training; Training Activity; Uganda; Universities; Viral; Washington; antiretroviral therapy; cancer prevention; cancer therapy; career development; experience; informant; medical schools; oncology; programs

DESCRIPTION (provided by applicant): The incidence of cancer among persons with HIV infection has increased annually since the widespread availability of antiretroviral therapy. Cancer is now a leading cause of death among HIV-positive persons, as survival after a diagnosis of an HIV-associated malignancy (HIVAM) is poorer compared with HIV-negative cancers across the world. In regions with a high prevalence of both HIV and viral oncogens, AIDS-defining malignancies such as Kaposi Sarcoma, non-Hodgkin lymphoma and cervical cancer present some of the largest threats to the health of HIV-infected individuals; non-AIDS defining cancers such at hepatocellular carcinoma, lung cancer and anal cancer now comprise >50% of HIVAM. New strategies are needed for cancer prevention and treatment among persons living with HIV in resource-limited settings. Since 2004, the Fred Hutchinson Cancer Research Center (FHCRC) has collaborated with the Uganda Cancer Institute (UCI) in Kampala, Uganda, to conduct research in HIVAM and develop new strategies for cancer treatment and prevention. Through several well-established training grants and strong relationships with our academic partners, the University of Washington (UW) and Makerere University (MU), we have trained >250 individuals in HIVAM research and care at all levels. Key informant interviews with academic, governmental and clinical leaders in Uganda find that a few gaps in the capacity to conduct HIVAM research persist. We propose to increase the capacity for independent research in HIVAM in Uganda through three Specific Aims: 1) Increase the number of Ugandan research scientists in HIVAM through the conferral of doctoral degrees with an established hybrid program between UW and MU; 2) Build the capacity for independent scientific research in HIVAM through a structured program of mentoring and career development; 3) Maintain capacity to implement HIVAM research in Uganda through ongoing short-term trainings in areas fundamental to research operations. The training activities will be overseen by an experienced and outstanding committee representing leaders in HIV and oncology research from the US and all Deans from three medical schools distributed across the country of Uganda, and will be rigorously measured and evaluated. By the completion of the five-year award period, >130 individuals will be trained in HIVAM research in Uganda, allowing for the conduct of a wide variety of research projects in HIVAM.

描述（由申请人提供）：自从广泛使用抗逆转录病毒疗法以来，艾滋病毒感染者的癌症发病率逐年增加。癌症现在是艾滋病毒阳性者死亡的主要原因，因为与全世界艾滋病毒阴性癌症相比，诊断出艾滋病毒相关恶性肿瘤 (HIVAM) 后的生存率较低。在艾滋病毒和病毒性致癌物流行率较高的地区，卡波西肉瘤、非霍奇金淋巴瘤和宫颈癌等艾滋病定义的恶性肿瘤对艾滋病毒感染者的健康构成了最大的威胁；目前，肝细胞癌、肺癌和肛门癌等非艾滋病定义的癌症占 HIVAM 的 50% 以上。在资源有限的环境中，需要制定新的策略来预防和治疗艾滋病毒感染者的癌症。自 2004 年以来，弗雷德·哈钦森癌症研究中心 (FHCRC) 与位于乌干达坎帕拉的乌干达癌症研究所 (UCI) 合作，开展 HIVAM 研究并制定癌症治疗和预防的新策略。通过多项完善的培训资助以及与我们的学术合作伙伴华盛顿大学 (UW) 和马凯雷雷大学 (MU) 的牢固关系，我们已经培训了超过 250 名各级 HIVAM 研究和护理人员。对乌干达学术、政府和临床领导者的主要知情人采访发现，进行 HIVAM 研究的能力仍然存在一些差距。我们建议通过三个具体目标提高乌干达 HIVAM 独立研究的能力： 1) 通过华盛顿大学和密西根大学之间既定的混合项目授予博士学位，增加乌干达 HIVAM 研究科学家的数量； 2) 通过结构化的指导和职业发展计划，建设 HIVAM 独立科学研究的能力； 3) 通过在研究业务基础领域持续进行短期培训，保持在乌干达实施 HIVAM 研究的能力。培训活动将由一个经验丰富、杰出的委员会监督，该委员会代表美国艾滋病毒和肿瘤学研究领域的领导者以及乌干达全国三所医学院的所有院长，并将接受严格的衡量和评估。五年奖励期结束时，将有超过 130 人在乌干达接受 HIVAM 研究培训，从而能够开展各种 HIVAM 研究项目。