Research Program: Global Oncology

全球肿瘤学计划 项目摘要/摘要 癌症日益被认为是对全世界人民健康的威胁。目前的估计是 到2020年，70%的新癌症病例将发生在低收入和中等收入国家。这些统计数据的驱动因素 包括由于总体健康和降低儿童和成人死亡率而延长寿命； 肥胖；更高的吸烟率；以及在非洲，与越来越多的 艾滋病毒的长期幸存者。这些趋势可能会持续下去。癌症死亡率也较高 资源贫乏的经济体。 全球肿瘤学计划(PIGO)的目标是开发一个强大的研究计划，允许- 国家调查人员将开发数据驱动的方法来预防和治疗#年癌症 以及发展一个强大的研究企业，利用资源和 这些国家有机会增进我们对癌症的了解，特别是那些在世界上罕见的癌症 在发达世界和发展中世界很常见。在美国以外进行的研究阐明了 新的癌症危险因素，描述了常见恶性肿瘤的独特分子特征，并建议 癌症预防和治疗的潜在新策略。小猪利用我们巨蟹座的资源 中心通过四个具体目标领导美国以外的有效研究：1)利用数据系统， 支持全球癌症监测的方法和可视化；2)扩大我们对艾滋病毒-肿瘤的研究- 以确定这些癌症的不同之处，利用 我们在乌干达、南非和中国选定的地区发展了人力和物质基础设施；3) 进一步制定强有力的多学科研究计划，以发现与感染相关的新癌症， 特别重视艾滋病毒感染者；以及4)制定有效的国内指导方针，以改善 在资源匮乏的环境中发现的常见癌症的检测、潜在预防和治疗。 PIGO有35名成员，来自FHCRC、UW和儿童部的3所学校和18个部门，资金为450万美元 2013财年同行评审资金(直接美元)，其中260万美元(49%)来自NCI。该计划 还有来自比尔和梅琳达·盖茨基金会的2140万美元(与癌症相关的部分)。成员们有 发表了322篇论文，其中10%是方案内论文，33%是方案内论文，18%是方案间论文 制度性的。

Program in Global Oncology Project Summary/Abstract Cancer is increasingly recognized as a threat to the health of people worldwide. Current estimates are that 70% of new cancer cases will be in low- and middle-income countries by 2020. Drivers of these statistics include increasing life spans due to overall health and reductions in childhood and adult mortality; increasing obesity; higher smoking rates; and, in Africa, increasing rates of cancer associated with the growing number of long-term survivors of HIV. These trends are likely to continue. Cancer mortality rates are also higher in resource-poor economies. The goal of the Program in Global Oncology (PiGO) is to develop a robust research program that allows in- country investigators to develop data-driven approaches to the prevention and treatment of cancers of relevance in their region, as well as to develop a robust research enterprise that leverages the resources and opportunities in these countries to increase our understanding of cancer, especially those that are rare in the developed world and common in the developing world. Research conducted outside the U.S. has elucidated novel cancer risk factors, described unique molecular signatures for common malignancies, and suggested potential new strategies for cancer prevention and treatment. PiGO leverages the resources of our Cancer Center to lead effective research outside the U.S. through four Specific Aims: 1) Leverage data systems, methods and visualization to support global surveillance of cancer; 2) Expand our studies of tumors from HIV- infected and non-HIV-infected individuals to determine how and whether these cancers differ, utilizing the human and physical infrastructure we have developed in Uganda, South Africa and select areas in China; 3) Further develop a robust multidisciplinary research program to discover novel infection-related cancers, with particular emphasis on HIV-infected individuals; and 4) Develop effective in-country guidelines to improve the detection, potential prevention and treatment of common cancers found in resource poor settings. PiGO has 35 members drawn from 3 schools and 18 departments of FHCRC, UW and Children's, and $4.5M in peer-reviewed funding (direct dollars) in fiscal year 2013, of which $2.6M (49%) is from NCI. The program also has $ 21.4M (cancer-relevant portion) from the Bill and Melinda Gates Foundation. Members have published 322 papers, of which 10% are intra-programmatic, 33% are intra-programmatic and 18% are inter- institutional.