MIT Laser Biomedical Research Center (P41-RR02594)

麻省理工学院激光生物医学研究中心 (P41-RR02594)

• 批准号: 8921198
• 负责人: Peter T. So
• 金额: $ 100.18万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8921198
• 关键词: Area; Automobile Driving; Biomedical Engineering; Biomedical Research; Biophotonics; Cancer Biology; Cancer Immunology Science; Cellular biology; Collaborations; Communities; Complex; Detection; Development; Diabetes Mellitus; Diagnosis; Funding; Glucose; Health; Institutes; Lasers; Leadership; Malaria; Massachusetts; Medical; Methods; Mission; Molecular Biology; Neurobiology; Pharmacologic Substance; Phase; Regenerative Medicine; Research; Research Personnel; Rest; Scientist; Services; Solutions; Spectrum Analysis; Stomach Diseases; Technology; Training; United States National Institutes of Health; biological research; cancer diagnosis; cancer therapy; design; infectious disease treatment; infrared spectroscopy; instrumentation; operation; photonics; research and development; spectroscopic imaging; success; tissue regeneration; tool; two-dimensional

DESCRIPTION: (provided by applicant): The Massachusetts Institute of Technology (MIT) Laser Biomedical Research Center (LBRC) requests NIH funding support for 26-30 years of operation. Under the leadership of its new Director, Dr. Peter So, LBRC will provide integrative photonic solutions to complex problems in biological research, pharmaceutical development, and medical diagnosis. Dr. So will be assisted by three Associated Directors: Drs. Ramachandra Dasari, Moungi Bawendi, and Andrie Tokmakoff. These senior investigators have a broad range of biophotonics expertise allowing LBRC to put forth three Technology Research and Development Projects proposing new biophotonic methods in the areas of (1) flurosecence instrumentation and probe, (2) phase-resolved spectroscopy and imaging, and (3) Raman and two-dimensional infrared spectroscopies. These TR&D projects are design to create new biophotonic tools for our collaborators to tackle important biomedical research problems in their respective fields. LBRC feature eight of these Driving Biomedical Projects covering the study of molecular and cell biology, neurobiology, cancer biology, diabetes diagnosis, and infectious disease treatment. In addition, LBRC also serve the biomedical community by disseminate matured technologies developed in the center. LBRC feature seven Collaborative Projects covering areas ranging from cancer, immunology, to tissue regeneration. Among these fifteen projects, half of these projects are led by investigators who have collaborated with LBRC in the past. The other half of these projects involves new researchers and new scientists. About 30 percent of these projects are conducted by teams led by clinicians. The rest of the projects are led by biologists or bioengineers. In additoin to research, collaboration and service, LBRC will also pursue a broad spectrum of activies in the dissemination of biophotonics technologies in the center and to train biomedical researcher in their uses. For the past 25 years, the success of LBRC has been built on research excellence and our ability to train stellar classes of biophotonics researchers. We look forward to carry on our mission and serve the biomedical community for the next five years.

产品说明：（申请人提供）：马萨诸塞州理工学院（MIT）激光生物医学研究中心（LBRC）请求NIH资助26-30年的运营。在新任主任Peter So博士的领导下，LBRC将为生物研究，药物开发和医疗诊断中的复杂问题提供综合光子解决方案。苏博士将得到三名副主任的协助：Ramachandra Dasari博士、Moungi Bawendi博士和Andrie Tokmakoff。这些资深研究人员拥有广泛的生物光子学专业知识，使LBRC能够提出三个技术研究和开发项目，提出新的生物光子学方法，涉及以下领域：（1）荧光仪器和探针，（2）相位分辨光谱和成像，以及（3）拉曼和二维红外光谱。这些研发项目旨在为我们的合作者创造新的生物光子工具，以解决各自领域的重要生物医学研究问题。LBRC的特色是其中八个驱动生物医学项目，涵盖分子和细胞生物学，神经生物学，癌症生物学，糖尿病诊断和传染病治疗的研究。此外，LBRC还通过传播中心开发的成熟技术为生物医学界服务。LBRC有七个合作项目，涵盖癌症，免疫学和组织再生等领域。在这15个项目中，有一半的项目是由过去曾与LBRC合作的调查人员领导的。这些项目的另一半涉及新的研究人员和新的科学家。这些项目中约有30%是由临床医生领导的团队进行的。其余的项目由生物学家或生物工程师领导。除了研究、合作和服务之外，LBRC还将在中心开展广泛的生物光子技术传播活动，并培训生物医学研究人员使用这些技术。在过去的25年里，LBRC的成功建立在卓越的研究和我们培养一流生物光子学研究人员的能力之上。我们期待着在未来五年继续履行我们的使命，为生物医学界服务。

项目成果

Quantitative dispersion microscopy.

• DOI: 10.1364/boe.1.000347
• 发表时间: 2010-09-01
• 期刊: Biomedical optics express
• 影响因子: 3.4
• 作者: Fu D;Choi W;Sung Y;Yaqoob Z;Dasari RR;Feld M
• 通讯作者: Feld M

Characterization of the fluorescent morphological structures in human arterial wall using ultraviolet-excited microspectrofluorimetry.

使用紫外激发显微分光荧光测定法表征人体动脉壁的荧光形态结构。

• DOI: 10.1016/0021-9150(91)90251-w
• 发表时间: 1991
• 期刊: Atherosclerosis
• 影响因子: 5.3
• 作者: Baraga,JJ;Rava,RP;Fitzmaurice,M;Tong,LL;Taroni,P;Kittrell,C;Feld,MS
• 通讯作者: Feld,MS

Phase-referenced probe interferometer for biological surface profiling and displacement measurements.

用于生物表面轮廓分析和位移测量的相位参考探针干涉​​仪。

• DOI: 10.1063/1.2823976
• 发表时间: 2007
• 期刊: The Review of scientific instruments
• 作者: Fang-Yen,Christopher;Chu,MarkC;Seung,HSebastian;Dasari,RamachandraR;Feld,MichaelS
• 通讯作者: Feld,MichaelS

Live cell refractometry using Hilbert phase microscopy and confocal reflectance microscopy.

• DOI: 10.1021/jp904746r
• 发表时间: 2009-11-26
• 期刊: The journal of physical chemistry. A
• 作者: Lue N;Choi W;Popescu G;Yaqoob Z;Badizadegan K;Dasari RR;Feld MS
• 通讯作者: Feld MS

Detecting high-grade squamous intraepithelial lesions in the cervix with quantitative spectroscopy and per-patient normalization.

通过定量光谱和每位患者的标准化检测宫颈中的高级鳞状上皮内病变。

• DOI: 10.1364/boe.2.002917
• 发表时间: 2011
• 期刊: Biomedical optics express
• 影响因子: 3.4
• 作者: Mirkovic,Jelena;Lau,Condon;McGee,Sasha;Crum,Christopher;Badizadegan,Kamran;Feld,Michael;Stier,Elizabeth
• 通讯作者: Stier,Elizabeth