Protein Structure and Function

蛋白质包括活细胞的大部分功能成分和许多结构成分。所以他们 对人类健康和疾病都至关重要。在过去的十年里，COBRE-PSF一直致力于 蛋白质结构和功能的基础健康相关研究。在此期间，我们帮助招募了25名新员工， 堪萨斯大学和我们的三个合作机构（堪萨斯州立大学）的生物医学研究教师 大学、威奇托州立大学和KU医学院）。我们还建造了三个非常成功的 科学核心实验室致力于a）蛋白质生产，B）蛋白质X射线晶体学，和c）生物分子 核磁共振波谱法。因此，COBRE-PSF在加强人类和物理方面做了很多工作 堪萨斯州的生物医学研究资源。该申请要求五年的资金， COBRE-PSF的第三阶段，在此期间，我们将追求以下目标：1）我们将继续发展 新的和持续的研究人员的临界质量集中在蛋白质结构的非常广泛的主题， 2）我们将继续利用我们的核心实验室，成功实施COBRE试点项目赠款计划; 3)我们将通过扩大现有核心实验室的能力和用户基础， 与KU研究中心合作，根据 产生的费用加上大学的支持基础的组合。这样做的结果将是一个非常 强大的成功的职业中期生物医学研究师资队伍和一个自我维持的核心实验室小组 支持全州范围内的蛋白质结构和功能研究COBRE-PSF的总体影响将 因此是实质性的和持久的。

Proteins comprise most of the functional and many of the structural components of living cells. Hence, they are vitally important to both human health and disease. For the past ten years COBRE-PSF has pursued basic health-related research in protein structure and function. While doing so we helped to recruit 25 new biomedical research faculty to The University of Kansas and our three partner institutions (Kansas State University, Wichita State University and the KU School of Medicine). We also built three highly successful scientific Core Labs dedicated to a) protein production, b) protein X-ray crystallography, and c) biomolecular NMR spectroscopy. As a result COBRE-PSF has done much to strengthen both the human and the physical resources for biomedical research in the state of Kansas. This application requests five years of funding for Phase III of COBRE-PSF, during which time we will pursue the following aims: 1) we will continue growing a critical mass of new and continuing investigators focused on the very broad theme of protein structure and function; 2) we will continue a successful program of COBRE pilot project grants that utilize our Core Labs; 3) we will strengthen our existing Core Labs by expanding their capabilities and their user base and by working with the KU Center For Research to position them for long-term sustainability based on a combination of fees generated plus a base of support from the University. The result of this will be a very strong cadre of successful mid-career biomedical research faculty and a self-sustaining group of Core Labs that support research in protein structure and function statewide. The overall impact of COBRE-PSF will thus be substantial and long-lasting.