Facilities Renovation under COBRE

描述（由申请人提供）： 该提案要求资金改造空间，用于在堪萨斯大学建立蛋白质结构和功能COBRE中心（1 P20 RR 17708 -01）。为研究用途而改造的空间目前要么根本不是实验室空间，要么是严重过时的实验室空间，不足以满足COBRE研究人员当前和未来的需求。改造后的空间将容纳一个专门用于蛋白质表达，纯化和表征的COBRE核心实验室（核心C），以及新的KU分析蛋白质组学实验室中的两个新质谱仪，这是一个专门用于蛋白质分析和蛋白质组学研究的共享研究设施，也将由COBRE研究人员使用。所要求的资金还将为KU和COBRE招聘的终身助理教授提供办公室实验室套件。将被改造的空间是在马洛特大厅，一个建筑，从1957年开始，并在1980年除了马洛特大厅。在较旧的区域（三楼），实验室的固定装置和通风柜现在已经过时，不适合当前的需要，实验室人员的休息室没有与实验室空间分开，实验室只有一个出口。即使在较新的区域（6楼），空调和空气质量也不足以满足当代的需求，实验室人员的办公空间与研究空间混杂在一起，实验室布局无法容纳计划中的新仪器。拟议的改造将弥补这些严重的年龄，设计和工程相关的缺陷，并将540平方英尺的目前非实验室空间转换为高品质的实验室空间。最近和正在进行的空气处理，电气和生命安全的改善在马洛特大厅使拟议的改造可行和及时。建议的改进是迫切需要的，将大大有助于实现该COBRE的具体和一般目标。它们还将补充KU正在进行的大量翻新工作，旨在实现其显著扩大其参与生命科学和生物医学研究的既定目标。集体的结果将是一个极好的设施，研究范围广泛的蛋白质相关的研究，从大规模的蛋白质组学的详细结构功能研究的个别蛋白质。

DESCRIPTION (provided by applicant): This proposal requests funds to remodel space that will be utilized in establishing a COBRE Center in Protein Structure and Function (1 P20 RR17708-01) at the University of Kansas. The space to be remodeled for research use is currently either not laboratory space at all, or is laboratory space that is seriously outdated and inadequate for current and future needs of COBRE investigators. The remodeled space will house a COBRE Core Lab dedicated to protein expression, purification and characterization (Core C), as well as two new mass spectrometers in the new KU Analytical Proteomics Laboratory, a shared research facility dedicated to protein analysis and proteomics research that will also be used by COBRE investigators. The requested funds will also provide an office-laboratory suite for a tenure-track assistant professor to be recruited to KU and the COBRE. The spaces to be remodeled are in Malott Hall, a building that dates from 1957, and in a 1980 addition to Malott Hall. In the older area (third floor), laboratory fixtures and hoods are now antiquated and poorly suited to current needs, workspaces for laboratory personnel are not separated from laboratory spaces, and labs have only one exit. Even in the newer areas (6th floor) the air conditioning and air quality are inadequate for contemporary needs, desk space for lab personnel is intermingled with research space, and the lab layouts cannot accommodate planned new instrumentation without some alterations. The proposed remodeling will remedy these serious age-, design- and engineering-related deficiencies, and will convert 540 square feet of current non-laboratory space into high-quality laboratory space. Recent and ongoing airhandling, electrical and life-safety improvements in Malott Hall make the proposed remodeling feasible and timely. The proposed improvements are sorely needed and will greatly facilitate achieving the specific and general goals of this COBRE. They will also complement substantial ongoing renovation efforts by KU aimed at achieving its stated goal of expanding significantly its involvement in life sciences and biomedical research. The collective result will be a superb facility for research in a broad range of protein-related studies from large-scale proteomics to detailed structure-function studies on individual proteins.