Mechanochemical studies of adenovirus cell entry

 描述(由申请人提供)：眼睛和呼吸道的急性腺病毒感染对免疫功能低下和正常的人来说仍然是一个严重的健康问题。这在一定程度上是由于对病毒如何在与特定受体(CAR和v整合素)相关联后入侵宿主细胞的了解不完全。在R21的这一应用中，拥有生物物理方法和基本分子病毒学专业知识的科学家将联手揭开受体结合导致的衣壳分解的复杂过程。这些研究可能为研究其他病毒在细胞感染过程中如何发生构象变化提供指导，并可能为设计新的抗病毒药物以阻止病毒宿主细胞进入开辟道路。

 DESCRIPTION (provided by applicant): Acute adenovirus infections of the eye and respiratory tract continue to be a significant health problem for both immunocompromised and normal individuals. This is due in part to an incomplete understanding of how the virus invades host cells following association with specific receptors (CAR and v integrins). In this R21 application, scientists with expertise in biophysical methods and basic molecular virology will team up to unravel the complex process of capsid disassembly that ensues from receptor binding. These studies could provide a guide for investigating how other viruses undergo conformational changes during cell infection and may open up an avenue for designing new antiviral agents to hinder virus host cell entry.