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Investigating the neuronal function of mammalian Latrophilins, candidate synaptic adhesion molecules implicated in ADHD.

Investigating the neuronal function of mammalian Latrophilins, candidate synaptic adhesion molecules implicated in ADHD.
研究哺乳动物 Latrophilins(与 ADHD 相关的候选突触粘附分子)的神经元功能。
批准号:
9131539
负责人:
Richard Cheslock Sando
金额:
$5.61万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2015
资助国家:
美国
项目状态:
已结题
起止时间:
2015-08-19 至 2018-08-18

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英文摘要
 DESCRIPTION (provided by applicant): Proper neural circuit function and behavior requires the establishment of connections between correct synaptic partners, maintenance of connections, and elimination of irrelevant synapses. Increasing evidence suggests that synaptic cell-adhesion molecules are essential for synapse formation. However, molecules essential for universal aspects of synapse formation, as well as molecules underlying the remarkable diversity and specificity of synaptic connections in vivo, remain to be elucidated. Mammalian latrophilins (Lphn1, 2, and 3) are adhesion-type GPCRs that have recently emerged as candidate synaptic cell adhesion molecules by heterophilic binding to teneurins and FLRTs. Lphns are highly enriched in the mammalian brain, and Lphn1 and 3 are transiently upregulated during the massive period of synaptogenesis in the brain. Lphns are also highly conserved across vertebrates and invertebrates, suggesting they may mediate universal aspects of synapse development. Moreover, polymorphisms in Lphn3 are correlated with ADHD, suggesting that Lphn3 regulates information processing. Despite these fascinating properties of Lphns, their precise biological roles in the nervous system remain elusive. We propose to investigate the neuronal function of Lphns by interrogating Lphn constitutive and conditional KO mice with viral-mediated neuronal tracing, histology, electrophysiology, and behavior. Furthermore, we will elucidate the molecular mechanisms of Lphn neuronal function using Lphn structure/function mutants, including polymorphisms associated with ADHD. These studies will provide insight into neuronal adhesion, synapse development, and a common human neurological disorder.
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Investigating how signaling via adhesion GPCR Latrophilins regulates synapse formation and specificity in the hippocampus
  • 批准号:
    10308817
  • 项目类别:
  • 资助金额:
    $24.9万
  • 财政年份:
    2018
  • 负责人:
    Richard Cheslock Sando
  • 依托单位:
Investigating how signaling via adhesion GPCR Latrophilins regulates synapse formation and specificity in the hippocampus
  • 批准号:
    10545731
  • 项目类别:
  • 资助金额:
    $23.96万
  • 财政年份:
    2018
  • 负责人:
    Richard Cheslock Sando
  • 依托单位:
Investigating how signaling via adhesion GPCR Latrophilins regulates synapse formation and specificity in the hippocampus
  • 批准号:
    10355545
  • 项目类别:
  • 资助金额:
    $24.44万
  • 财政年份:
    2018
  • 负责人:
    Richard Cheslock Sando
  • 依托单位:
Transcriptional control of activity-dependent synaptic plasticity
  • 批准号:
    8527454
  • 项目类别:
  • 资助金额:
    $2.92万
  • 财政年份:
    2013
  • 负责人:
    Richard Cheslock Sando
  • 依托单位:
海外基金