Endothelium/Descemet's membrane Complex Optical Tomography
内皮/后弹力层复合光学断层扫描
基本信息
- 批准号:9014307
- 负责人:
- 金额:$ 22.83万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-01-01 至 2020-12-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdvisory CommitteesAffectAlgorithmsBasement membraneBiophysicsCell physiologyCharacteristicsClinicClinical ResearchComplexCorneaCorneal EndotheliumDataDependencyDescemet&aposs membraneDeteriorationDevelopmentDevelopment PlansDiagnosisDiagnosticDiagnostic ProcedureDiagnostic SensitivityDiagnostic SpecificityDimensionsDiseaseDoctor of MedicineDoctor of PhilosophyEarly DiagnosisEndothelial CellsEndotheliumEvolutionEyeFailureFuchs&apos Endothelial DystrophyFunctional disorderFutureGoalsGraft RejectionHydration statusImageImaging technologyInjuryInstitutesKeratoplastyKnowledgeManualsMapsMeasuresMembraneMentorshipMulti-Institutional Clinical TrialNatural regenerationOptical Coherence TomographyOptical TomographyOrgan TransplantationPathologyPatientsPeripheralPilot ProjectsPrincipal InvestigatorProceduresQuality of lifeResearchResearch ActivityRiskScanningScientistSecondary toSensitivity and SpecificitySolidSpecialistStagingStressStructureSwellingTechniquesTechnologyTestingThickTimeTrainingTransplantationUnited StatesValidationVariantVisionVision researchaccurate diagnosisbasecareercareer developmentcell injuryendothelial dysfunctionexperiencefallsfunctional lossfunctional statusimage processingimmunological statusimprovedin vivoinstrumentationnovelnovel therapeuticspatient oriented researchpreventprogramsprospectivepublic health relevanceskillssuccesstechnology/techniquetomographytool
项目摘要
DESCRIPTION (provided by applicant): More than 50% of corneal transplants, the most common form of solid organ transplantation, are performed to restore vision lost secondary to corneal endothelial failure. More than 25% of those transplants will eventually fail and endothelial cell rejection leading to failure is the single most important cause. The key to protec the endothelium is the early and accurate diagnosis of cell injury to promptly initiate treatment before irreversible damage occurs. Current diagnostic techniques fall short in protecting endothelial cells. Our pilot studies, aimed at addressing this critical need, revealed great potential of using in vivo corneal endothelium/Descemet's membrane (En/DM) characteristics, disclosed using high definition optical coherence tomography (HDOCT), in diagnosing corneal graft rejection. Yet, they also highlighted technology limitations hindering establishing this nove technique. This proposed research activity will focus on advancing HDOCT technology to better describe corneal grafts En/DM and validating, in the setting of a clinical study, the utility of th developed technology to early and accurately diagnose graft rejection. This project is led by Mohamed Abou Shousha, M.D., FRCS, Ph.D., of the Bascom Palmer Eye Institute (BPEI). He is a highly trained cornea specialist with broad experience in corneal imaging and patient oriented research. His career goals include developing the knowledge and skills to become an independent clinician-scientist while establishing diagnostic techniques to better diagnose corneal endothelial injury to decrease risk of endothelial failure and test his techniques in multi center clinical trials. The three aims of this proposal reflect his goals and include: (1) development and validation of automated En/DM tomographic thickness maps, to address technology limitations that only allow manual En/DM segmentation, which is time consuming, operator dependent and ignores tomography as an important dimension of En/DM structure. (2) Development and validation of instrumentations to extend En/DM images to include the paracentral and peripheral corneal graft, to address current technology limitation, which is the inability to describe the paracentral and peripheral En/DM despite that those are where rejection typically starts. (3) Verify the prediction that wide corneal graft En/DM tomographic thickness maps can diagnose corneal graft rejection more accurately and at an earlier stage than central En/DM thickness through a proof of concept clinical study. In addition to the research activity, he
has a highly structured career development plan to further his research skills and develop the solid base for a successful career as an independent clinician- scientist. He has assembled an outstanding mentorship team (Drs. Victor Perez, Fabrice Manns, and Sonia Yoo) with extensive experience in basic, translational and patient oriented research focused on corneal grafts rejection and biomedical corneal imaging technology. He has also developed a strong scientific advisory committee and partnerships with collaborators at the BPEI's McKnight Vision Research Center and Ophthalmic Biophysics Center to strengthen his proposal and the likelihood of both short-term and long-term success.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(2)
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Mohamed Fadel Abou Shousha其他文献
Mohamed Fadel Abou Shousha的其他文献
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{{ truncateString('Mohamed Fadel Abou Shousha', 18)}}的其他基金
Wide-field corneal microlayer tomography for keratoconus
圆锥角膜的广角角膜微层断层扫描
- 批准号:
10543502 - 财政年份:2022
- 资助金额:
$ 22.83万 - 项目类别:
Wide-field corneal microlayer tomography for keratoconus
圆锥角膜的大视场角膜微层断层扫描
- 批准号:
10341931 - 财政年份:2022
- 资助金额:
$ 22.83万 - 项目类别:
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0451289 - 财政年份:2005
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$ 22.83万 - 项目类别:
Standard Grant