Vitamin D, Steroids, and Asthma in African American Youth
Vitamin D, Steroids, and Asthma in African American Youth
批准号:
9002854
负责人:
Robert J Freishtat
金额:
$43.0万
依托单位国家:
美国
项目类别:
财政年份:
2012
资助国家:
美国
项目状态:
已结题
起止时间:
2012-04-01 至 2018-01-31
关键词:
25-hydroxyvitamin DAccident and Emergency departmentAcuteAddressAffectAfrican AmericanAsthmaCaringCellsChronicDetectionDexamethasoneDisadvantagedDistrict of ColumbiaDoseEnrollmentEnvironmentEnvironmental Risk FactorEpidemiologyEpithelial CellsEthnic OriginEthnic groupExposure toGlucocorticoidsGoalsHealthy People 2010HeterogeneityIn VitroIndividualInflammation MediatorsInflammatoryInterleukin-1Interleukin-10Intervention TrialKnowledgeLinkMeasuresMessenger RNAMethodsMinorityMitogen-Activated Protein KinasesModelingMolecularNoseObesityOutcomeParticipantPhosphoric Monoester HydrolasesPopulationPrevalenceProteinsRaceRandomized Clinical TrialsRegulationResearchRespiratory Tract InfectionsRiskRoleSamplingSerumSeveritiesSteroidsStructure of parenchyma of lungTechniquesTestingTimeTransforming Growth FactorsTranslationsVisitVitamin DVitamin D DeficiencyVitamin D supplementationYouthabstractingairway epitheliumasthmatic airwayclinical research sitecohortcytokinedisparity reductionethnic differenceexperiencehealth disparityinsightnovelprospectiveracial and ethnicresearch studyrespiratoryresponseurban area
中文摘要
摘要
迫切需要进一步研究,以确定有效和可持续的战略,
贫困、城市和少数民族哮喘青年所经历的巨大健康差异。维生素
D缺乏症在非洲裔美国人(AA)中更为常见,尤其是来自城市的人
环境或肥胖。我们和其他人已经为越来越多的证据做出了贡献,
营养不足可能通过增加呼吸道感染的风险导致更严重的哮喘,
糖皮质激素敏感性降低。事实上,维生素D水平低最近与需要
外源性糖皮质激素和哮喘严重程度增加。与健康差距特别相关的是,我们
在城市非洲裔美国人(AA)中,维生素D不足与哮喘之间存在很强的关联
青年因为居住在华盛顿市区的AA青少年的哮喘明显比其他地区的青少年严重,
种族/族裔群体(例如,发病率比全国发病率高20%,
利用率达到全国利用率的5倍,接近2010年健康人口目标利用率的10倍),
我将利用我们对哮喘差异极端人群的访问,检查
维生素D对慢性控制和哮喘急性严重程度的差异。此应用程序的总体目标
是提供关键的流行病学/分子信息,为解释正在进行的
即将进行的补充维生素D治疗哮喘的随机临床试验,特别是在城市
青少年哮喘在这个应用程序中的实验所产生的知识将是至关重要的,
翻译这种便宜,容易获得的哮喘潜在疗法。我们假设低血清
25-羟维生素D [25(OH)D]水平与慢性哮喘控制不良、急性哮喘恶化
严重性和糖皮质激素不敏感性。AIM 1.定义哮喘表型簇并确定交叉-
AA和非AA患者血清25(OH)D水平的分段群间和群内相关性
青年AIM 2.确定血清25(OH)D水平与以下因素之间的前瞻性关联:(a)慢性哮喘
对照组和(B)AA和非AA青年内和之间的急性哮喘严重程度。AIM 3.显示效果的
维生素D对糖皮质激素调节哮喘气道上皮细胞炎症介质的影响
英文摘要
Abstract
Further studies are urgently needed in order to identify effective and sustainable strategies for reducing
the dramatic health disparities experienced by disadvantaged, urban, and minority youth with asthma. Vitamin
D deficiency is more common among African American (AA) individuals, especially those from urban
environments or with obesity. We and others have contributed to increasing evidence that vitamin D
insufficiency may contribute to more severe asthma through increased risk of respiratory infection and
decreased glucocorticoid sensitivity. Indeed, low vitamin D levels were recently linked with the need for
exogenous glucocorticoids and increased asthma severity. Particularly relevant to health disparities, we
showed a strong association between vitamin D insufficiency and asthma in urban African American (AA)
youth. Because AA youth residing in urban Washington, DC have markedly worse asthma than other
racial/ethnic groups (e.g. prevalence rate 20% higher than the national rate 15 and emergency department
utilization rates up to 5 times the national rates and nearly 10 times the Healthy People 2010 target rate), we
will utilize our access to this population at the extreme of asthma disparities to examine the contribution of
vitamin D to disparities in the chronic control and acute severity of asthma. The overall goal of this application
is to provide critical epidemiological/molecular information that will inform the interpretation of ongoing and
impending randomized clinical trials of vitamin D supplementation in asthma, especially with regard to urban
AA youth with asthma. The knowledge generated by the experiments in this application will be crucial to
translation of this inexpensive, easily-accessible potential therapy for asthma. We hypothesize that low serum
25-hydroxyvitamin D [25(OH)D] levels are associated with poor chronic asthma control, worse acute asthma
severity, and glucocorticoid insensitivity. AIM 1. Define asthma phenotypic clusters and determine cross-
sectional inter- and intra-cluster associations with serum 25(OH)D levels within and between AA and non-AA
youth. AIM 2. Determine prospective associations among serum 25(OH)D levels and: (a) chronic asthma
control and (b) acute asthma severity within and between AA and non-AA youth. AIM 3. Show the effect of
vitamin D on glucorticoid regulation of inflammatory mediators in asthmatic airway epithelial cells.
期刊论文(9)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
DOI:
10.1038/srep46026
发表时间:
2017-04-06
期刊:
Scientific reports
影响因子:
4.6
作者:
[Bartel S, Schulz N, Alessandrini F, Schamberger AC, Pagel P, Theis FJ, Milger K, Noessner E, Stick SM, Kicic A, Eickelberg O, Freishtat RJ, Krauss-Etschmann S]
通讯作者:
Krauss-Etschmann S
Nasopharyngeal Microbiome Diversity Changes over Time in Children with Asthma.
哮喘儿童的鼻咽微生物组多样性随着时间的流逝而变化。
DOI:
10.1371/journal.pone.0170543
发表时间:
2017
期刊:
PloS one
影响因子:
3.7
作者:
[Pérez-Losada M, Alamri L, Crandall KA, Freishtat RJ]
通讯作者:
Freishtat RJ
Two sampling methods yield distinct microbial signatures in the nasopharynges of asthmatic children.
DOI:
10.1186/s40168-016-0170-5
发表时间:
2016-06-16
期刊:
Microbiome
影响因子:
15.5
作者:
[Pérez-Losada M, Crandall KA, Freishtat RJ]
通讯作者:
Freishtat RJ
DOI:
10.1513/annalsats.201402-084oc
发表时间:
2014-07-01
期刊:
Annals of the American Thoracic Society
影响因子:
8.3
作者:
[Fu, Liang, Freishtat, Robert J, Wang, Zuyi]
通讯作者:
Wang, Zuyi
DOI:
10.1186/s12920-015-0121-1
发表时间:
2015-08-16
期刊:
BMC medical genomics
影响因子:
2.7
作者:
[Castro-Nallar E, Shen Y, Freishtat RJ, Pérez-Losada M, Manimaran S, Liu G, Johnson WE, Crandall KA]
通讯作者:
Crandall KA
共 8 条
Children's National Stimulating Access to Research in Residency (CNStARR) Program (NHLBI)
-
批准号:10202708
-
项目类别:
-
资助金额:$36.39万
-
财政年份:2018
-
负责人:Robert J Freishtat
-
依托单位:
Children's National Stimulating Access to Research in Residency (CNStARR) Program (NHLBI)
-
批准号:9596369
-
项目类别:
-
资助金额:$39.45万
-
财政年份:2018
-
负责人:Robert J Freishtat
-
依托单位:
Maternal Adipocyte-Derived Exosomes in the Thin-Fat Indian Baby Paradox
-
批准号:9766906
-
项目类别:
-
资助金额:$18.81万
-
财政年份:2018
-
负责人:Robert J Freishtat
-
依托单位:
Children's National Stimulating Access to Research in Residency (CNStARR) Program (NIAID)
-
批准号:10229509
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2018
-
负责人:Robert J Freishtat
-
依托单位:
Children's National Stimulating Access to Research in Residency (CNStARR) Program (NIAID)
-
批准号:9977960
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2018
-
负责人:Robert J Freishtat
-
依托单位:
K12 Career Development Program: Omics of Pediatric Lung Diseases in DC
-
批准号:9294122
-
项目类别:
-
资助金额:$31.19万
-
财政年份:2013
-
负责人:Robert J Freishtat
-
依托单位:
K12 Career Development Program: Omics of Pediatric Lung Diseases in DC
-
批准号:9069941
-
项目类别:
-
资助金额:$31.19万
-
财政年份:2013
-
负责人:Robert J Freishtat
-
依托单位:
Research on Sex/Gender Differences
-
批准号:8852011
-
项目类别:
-
资助金额:$10.0万
-
财政年份:2012
-
负责人:Robert J Freishtat
-
依托单位:
Vitamin D, Steroids, and Asthma in African American Youth
-
批准号:8795111
-
项目类别:
-
资助金额:$43.0万
-
财政年份:2012
-
负责人:Robert J Freishtat
-
依托单位:
Vitamin D, Steroids, and Asthma in African American Youth
-
批准号:8281784
-
项目类别:
-
资助金额:$43.0万
-
财政年份:2012
-
负责人:Robert J Freishtat
-
依托单位:
Vitamin D, Steroids, and Asthma in African American Youth
-
批准号:8449601
-
项目类别:
-
资助金额:$40.21万
-
财政年份:2012
-
负责人:Robert J Freishtat
-
依托单位:
Vitamin D, Steroids, and Asthma in African American Youth
-
批准号:8607477
-
项目类别:
-
资助金额:$43.0万
-
财政年份:2012
-
负责人:Robert J Freishtat
-
依托单位:
GENOME SCREEN FOR ASTHMA SEVERITY MODIFIER POLYMORPHISMS
-
批准号:8167355
-
项目类别:
-
资助金额:$4.7万
-
财政年份:2010
-
负责人:Robert J Freishtat
-
依托单位:
TEMPORAL ANALYSIS OF PLATELETS AS CYTOTOXIC MEDIATORS IN SEPSIS
-
批准号:7951117
-
项目类别:
-
资助金额:$0.09万
-
财政年份:2008
-
负责人:Robert J Freishtat
-
依托单位:
GENOME SCREEN FOR ASTHMA SEVERITY MODIFIER POLYMORPHISMS
-
批准号:7951125
-
项目类别:
-
资助金额:$3.85万
-
财政年份:2008
-
负责人:Robert J Freishtat
-
依托单位:
GENOME SCREEN FOR ASTHMA SEVERITY MODIFER POLYMORPHISMS
-
批准号:7717200
-
项目类别:
-
资助金额:$0.07万
-
财政年份:2007
-
负责人:Robert J Freishtat
-
依托单位:
GENOME SCREEN FOR ASTHMA SEVERITY MODIFER POLYMORPHISMS
-
批准号:7608387
-
项目类别:
-
资助金额:$0.03万
-
财政年份:2006
-
负责人:Robert J Freishtat
-
依托单位:
MENTORED PATIENT-ORIENTED RESEARCH CAREEER DEVELOPMENT AWARD
-
批准号:7123925
-
项目类别:
-
资助金额:$12.47万
-
财政年份:2005
-
负责人:Robert J Freishtat
-
依托单位:
TECHNIQUES FOR ISOLATION OF MONONUCLEAR CELLS FROM HUMAN RESPIRATORY WASHINGS
-
批准号:7199688
-
项目类别:
-
资助金额:$0.49万
-
财政年份:2005
-
负责人:Robert J Freishtat
-
依托单位:
TEMPORAL ANALYSIS OF MRNA AND PROTEIN EXPRESSION IN CELLS OF INNATE IMMUNITY AN
-
批准号:7376190
-
项目类别:
-
资助金额:$0.1万
-
财政年份:2005
-
负责人:Robert J Freishtat
-
依托单位: