K12 Career Development Program: Omics of Pediatric Lung Diseases in DC

K12 职业发展计划：华盛顿特区小儿肺部疾病组学

• 批准号: 9069941
• 负责人: Robert J Freishtat
• 金额: $ 31.19万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9069941
• 关键词: Address; Advisory Committees; Affinity; Applications Grants; Area; Bioinformatics; Biology; Biometry; Boxing; Child; Childhood; Clinical; Data; Data Sources; Disease; District of Columbia; Doctor of Philosophy; Educational Curriculum; Environment; Genetic; Genetic Medicine; Genomics; Goals; Grant; Health; Health Sciences; Laboratories; Lead; Learning; Lung; Lung diseases; Medical center; Medicine; Mentored Clinical Scientist Development Program; Mentors; Methodology; Minority Recruitment; Performance; Phenotype; Physicians; Principal Investigator; Proteomics; Research; Research Methodology; Research Personnel; SECTM1 gene; Scientist; Structure; Supervision; Systems Biology; Time; Training; Translating; United States National Institutes of Health; Universities; Washington; Work; base; career development; clinical phenotype; epigenomics; experience; medical schools; next generation sequencing; personalized medicine; pre-clinical; programs; skills; tool

DESCRIPTION (provided by applicant): We propose a K12 Career Development Program on Omics of Pediatric Lung Diseases DC based within the Department of Integrative Systems Biology (ISB), George Washington University School of Medicine and Health Sciences (GW), and fully commensurate with the Center for Genetic Medicine Research (GenMed) at Children's National Medical Center (CNMC) in Washington DC (ISB/GenMed) (see www.gwumc.edu/isbweb). Omics is a systems biology approach to biology in health and disease, and an underlying lynch pin for the emergence of 'personalized medicine'. Providing career development support in omics of lung diseases is timely and highly important for both physician/scientists and PhD scientists A fundamental problem is that systems biology approaches utilizing multi-level omics data sources are exceptionally multi-disciplinary, requiring the lung researcher to have working expertise in many areas of academic endeavor that were, previously, considered distinct (aka 'siloed'). The key challenge for K12 omics career development programs is to break down traditional siloes in academic medicine, providing a large research tool box to the Scholar that ranges from epigenomics, to bioinformatics of next-generation sequence data, to phenotype/environment interactions. Our K12 program responds to this need by providing time for Scholars to: 1) take coursework in omics and systems biology relevant to their research; 2) learn state-of-the art laboratory methodology in genomics, proteomics, and bioinformatics; 3) develop preliminary data under the supervision of a Lead Mentor and Mentoring Team that will lead to submission of an independent NIH grant application; and 4) learn to effectively translate their accomplishments to the improvement of pediatric lung diseases. In order to accomplish their goals the K12 Scholars will spend at least 75% effort honing these skills over a 1-3 year period of time, depending on past experience and topic area. During this period each of the above goals is addressed in a systematic fashion including participation in a core curriculum in research methodology and biostatistics and performance of increasingly independent research in the laboratory of a Lead Mentor. Our proposed K12 program draws 11 Lead Mentors and 16 secondary Mentors from the ISB/GenMed roster who will function as a Mentoring Team in four Affinity areas: Genetics and Genomics; Proteomics; Bioinformatics, and Clinical and Pre-Clinical Phenotyping. The administrative structure of the K12 includes two Co-Principal Investigators with complementary expertise in omics and lung biology/diseases who will serve as Program Director and Career Development Director, respectively, a Director of Minority Recruitment, and internal and external advisory committees. We propose to select and train a total of 2-4 K12 Scholars during a 5 year grant period.

描述(由申请人提供)：我们建议在乔治华盛顿大学医学和健康科学学院(GW)综合系统生物学系(ISB)内设立一个关于儿童肺部疾病欧姆克的K12职业发展计划，并与华盛顿特区儿童国家医学中心(CNMC)的遗传医学研究中心(GenMed)完全相称(ISB/GenMed)(见www.gwumc.edu/isbweb)。组学是一种系统生物学方法，研究健康和疾病方面的生物学，是“个性化医学”出现的根本原因。提供肺部疾病组学方面的职业发展支持对医生/科学家和博士生来说都是及时和非常重要的。一个根本的问题是，利用多水平组学数据来源的系统生物学方法是非常多学科的，需要 肺脏研究人员在以前被认为是不同的学术努力的许多领域拥有工作专业知识(也称为“竖井”)。K12组学职业发展计划的关键挑战是打破学术医学中的传统竖井，为学者提供一个大型研究工具箱，范围从表观基因组学到下一代序列数据的生物信息学，再到表型/环境相互作用。我们的K12计划通过为学者提供时间来回应这一需求：1)学习与他们的研究相关的组学和系统生物学的课程；2)学习基因组学、蛋白质组学和生物信息学的最先进的实验室方法；3)在首席导师和指导团队的监督下开发初步数据，这将导致提交独立的NIH拨款申请；以及4)学习有效地将他们的成就转化为改善儿科肺部疾病。为了实现他们的目标，K12学者将花费至少75%的努力在1-3年的时间内磨练这些技能，这取决于过去的经验和主题领域。在此期间，上述目标中的每一项都是以系统的方式进行的，包括参加研究方法和生物统计学的核心课程，以及在首席导师的实验室开展日益独立的研究。我们建议的K12计划从ISB/GenMed花名册中吸引了11名首席导师和16名二级导师，他们将在四个亲和力领域发挥指导团队的作用：遗传学和基因组学；蛋白质组学；生物信息学，以及临床和临床前表型分析。K12的行政结构包括两名在组学和肺部生物学/疾病方面具有互补专业知识的联合首席调查员，他们将分别担任项目主任和职业发展主任，一名少数族裔招聘主任，以及内部和外部咨询委员会。我们建议在五年的资助期内挑选和培训2-4名K12奖学金获得者。