PATHOGENESIS OF ALZHEIMERS DISEASE AND RELATED DISORDERS: MECHANISM OF TAU PATHOLOGY
PATHOGENESIS OF ALZHEIMERS DISEASE AND RELATED DISORDERS: MECHANISM OF TAU PATHOLOGY
批准号:
nhmrc : 570920
负责人:
Prof Jurgen Gotz
金额:
$19.74万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2009
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2009-01-01 至 2011-12-31
中文摘要
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英文摘要
A protein called tau has an essential role in the pathogenesis of Alzheimer's disease (AD), frontotemporal dementia (FTD) and related dementias. We have developed novel transgenic models, which allow us to treat the mice and to abrogate the clinical symptoms. As we have dissected the underlying molecular mechanisms, our ultimate goal is to develop a treatment approach based on these mechanisms and thereby reduce the socio-economic burden of these debilitating diseases.
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会议论文
Role of the microglial adaptor molecule TYROBP in Alzheimer’s disease pathology
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批准号:nhmrc : 1147569
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项目类别:Project Grants
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资助金额:$31.3万
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财政年份:2018
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负责人:Prof Jurgen Gotz
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依托单位:
SELECTIVE VULNERABILITY IN ALZHEIMER’S DISEASE AND RELATED DISORDERS: MECHANISM OF TAU PATHOLOGY
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批准号:nhmrc : 1003150
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项目类别:Project Grants
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资助金额:$71.5万
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财政年份:2011
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负责人:Prof Jurgen Gotz
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依托单位:
Comparative analysis of novel transgenic mouse models for brain and islet amyloidoses
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批准号:nhmrc : 512484
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项目类别:NHMRC Project Grants
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资助金额:$31.21万
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财政年份:2008
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负责人:Prof Jurgen Gotz
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依托单位:
Alzheimer's disease and related disorders: Mechanism of tau pathology in established and novel transgenic animal models
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批准号:nhmrc : 402596
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项目类别:NHMRC Project Grants
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资助金额:$28.21万
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财政年份:2006
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负责人:Prof Jurgen Gotz
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依托单位:
海外基金