PATHOGENESIS OF ALZHEIMERS DISEASE AND RELATED DISORDERS: MECHANISM OF TAU PATHOLOGY

阿尔茨海默病及相关疾病的发病机制：TAU 病理学机制

• 批准号: nhmrc : 570920
• 负责人: Prof Jurgen Gotz
• 金额: $ 19.74万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pathogenesis-alzheimers-disease-tau-pathology/97405
• 关键词: PATHOGENESIS; ALZHEIMERS; DISEASE; RELATED; DISORDERS

A protein called tau has an essential role in the pathogenesis of Alzheimer's disease (AD), frontotemporal dementia (FTD) and related dementias. We have developed novel transgenic models, which allow us to treat the mice and to abrogate the clinical symptoms. As we have dissected the underlying molecular mechanisms, our ultimate goal is to develop a treatment approach based on these mechanisms and thereby reduce the socio-economic burden of these debilitating diseases.

一种名为tau的蛋白质在阿尔茨海默病(AD)、额颞叶痴呆(FTD)和相关痴呆的发病机制中起着至关重要的作用。我们开发了新的转基因模型，使我们能够治疗小鼠并消除临床症状。由于我们已经剖析了潜在的分子机制，我们的最终目标是开发一种基于这些机制的治疗方法，从而减少这些令人衰弱的疾病的社会经济负担。