Role of the microglial adaptor molecule TYROBP in Alzheimer’s disease pathology

小胶质细胞接头分子 TYROBP 在阿尔茨海默病病理学中的作用

• 批准号: nhmrc : 1147569
• 负责人: Prof Jurgen Gotz
• 金额: $ 31.3万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-microglial-adaptor-disease-pathology/1320880
• 关键词: Role; microglial; adaptor; molecule; TYROBP

Immune activation characterizes Alzheimer’s disease (AD) brains; however, how it impacts AD progression is not understood. Our previous studies in AD brains identified the immune molecule TYROBP, pointing at both beneficial and detrimental effects triggered by this molecule. Here, we aim to understand in detail how TYROBP is involved in AD and how we can enhance its beneficial effects and decrease its unintended actions.

免疫激活是阿尔茨海默病（AD）大脑的特征;然而，它如何影响AD进展尚不清楚。我们之前在AD大脑中的研究确定了免疫分子TYROBP，指出了这种分子引发的有益和有害影响。在这里，我们的目标是详细了解TYROBP如何参与AD，以及我们如何增强其有益效果并减少其意外作用。