SELECTIVE VULNERABILITY IN ALZHEIMER’S DISEASE AND RELATED DISORDERS: MECHANISM OF TAU PATHOLOGY

阿尔茨海默病和相关疾病的选择性脆弱性：TAU 病理学机制

• 批准号: nhmrc : 1003150
• 负责人: Prof Jurgen Gotz
• 金额: $ 71.5万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/selective-vulnerability-alzheimers-tau-pathology/108903
• 关键词: SELECTIVE; VULNERABILITY; ALZHEIMER; DISEASE; RELATED

Alzheimer’s disease and related dementias affect 230,000 people in Australia, with numbers expected to grow to 730,000 by 2050. The direct costs for health and residential care alone exceed $6.6 billion per annum. By identifying genes that protect degenerating neurons in the Alzheimer brain, a deeper understanding of the underlying processes will be gained and therapeutic targets will be defined that will assist in developing a therapy for a yet uncurable disease.

在澳大利亚，阿尔茨海默病和相关的痴呆症影响着23万人，预计到2050年，这一数字将增长到73万。仅在保健和住宿护理方面的直接费用每年就超过66亿美元。通过识别保护阿尔茨海默病大脑中退化神经元的基因，人们将对潜在的过程有更深的了解，并将确定治疗目标，以帮助开发一种治疗这种尚未治愈的疾病的方法。