SELECTIVE VULNERABILITY IN ALZHEIMER’S DISEASE AND RELATED DISORDERS: MECHANISM OF TAU PATHOLOGY

阿尔茨海默病和相关痴呆症影响着澳大利亚的23万人，预计到2050年将增加到73万人。单是医疗和住宿照顾的直接成本，每年便超过66亿元。通过鉴定保护阿尔茨海默病大脑中退化神经元的基因，将获得对潜在过程的更深入了解，并将确定治疗靶点，这将有助于开发治疗尚未治愈的疾病的疗法。

Alzheimer’s disease and related dementias affect 230,000 people in Australia, with numbers expected to grow to 730,000 by 2050. The direct costs for health and residential care alone exceed $6.6 billion per annum. By identifying genes that protect degenerating neurons in the Alzheimer brain, a deeper understanding of the underlying processes will be gained and therapeutic targets will be defined that will assist in developing a therapy for a yet uncurable disease.