Minimally Verbal ASD: From Basic Mechanisms to Innovative Interventions
最低程度言语自闭症谱系障碍:从基本机制到创新干预措施
基本信息
- 批准号:9130810
- 负责人:
- 金额:$ 185.26万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-09-04 至 2019-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdolescentAdultAreaAssessment toolAttentionAuditoryAutistic DisorderBehavioralBiologicalBiological MarkersBostonCaringChildClinicalClinical ResearchCognitiveCommunicationCommunitiesEarly DiagnosisElectrophysiology (science)EmotionalFailureFamilyGoalsImpairmentIndividualInterventionInvestigationKnowledgeLanguageLeadLinguisticsMeasuresMedicalMedicineMethodsModelingMolecularNatureNeurobiologyNeuronsOutcomeOutcome MeasurePathway interactionsPatternPerceptionPhenotypePilot ProjectsPopulationProductionProteinsRandomized Clinical TrialsResearchResearch PersonnelResearch TrainingResolutionRiskRisk MarkerSafetySchool-Age PopulationSchoolsSeriesSocietiesSpeechStrategic PlanningTarget PopulationsTestingTherapeutic InterventionTissue SampleToddlerTraining and EducationTreatment outcomeUniversitiesUrsidae Familyautism spectrum disorderaxon growthbasebrain tissueclinical practicecollegecomputational neurosciencedata managementdesignindexinginfancyinnovationinterestmedical schoolsminority childrenmolecular targeted therapiesneglectneuroimagingnovelpredicting responserelating to nervous systemrepetitive behaviorresponseskillssocial communicationsuccesssuccessful interventiontheoriestooltreatment responsewhite matter
项目摘要
DESCRIPTION: A critical gap identified in the 2011 lACC Strategic Plan is the dearth of knowledge about older children and adults who fail to acquire spoken language. Little is known about these individuals because current assessment tools and practices are not adequate for this population. More significantly, there are no models that explain why about 30% of the ASD population remains minimally verbal and no interventions that specifically and uniquely target this population in promoting spoken language. The goals of our ACE are to address these issues, bringing tools, methods, and approaches have drawn from others areas of speech, auditory, clinical, and computational neurosciences. Our ACE, located at Boston University, brings together researchers from across the university and collaborators from Harvard Medical School, Northeastern University and Albert Einstein College of Medicine. The interconnected projects in the ACE include: a novel intervention to promote spoken language in school-aged children with ASD (Project I); investigation of biological markers of treatment response and outcome (Projects I, II, and III); investigation of mechanisms that might underlie the failure to speak including (a) structural and functional connectivity impairments in key nodes of the speech production network according to the DIVA model (Project 11); (b) abnormalities in the perception, organization and analysis of auditory scenes as indexed in electrophysiological responses and neural oscillatory patterns (Project III); disruptions in excitatory and inhibitory neuronal pathways in key prefrontal cortical areas associated with language using high resolution methods to investigate white matter and axonal growth proteins in tissue samples (Project IV). The projects are united and served by an Administration and Data Management Core (A), a Research Training and Education Core (B) and a Clinical Core (C), which will carry out comprehensive assessments using standard and novel experimental measures to capture the heterogeneous phenotypes of minimally verbal children with ASD, and that will be used to explain variability in treatment response and mechanistic factors identified in the Projects. Together, the research conducted in our ACE will significantly advance our understanding of this neglected end of the autism spectrum, provide innovative approaches to assessment and treatment, pave the way for identifying biological markers predict who will fail to acquire speech, and highlight potential molecular targets for therapeutic interventions.
描述:2011年lACC战略计划中确定的一个关键差距是缺乏关于未能获得口语的大龄儿童和成人的知识。人们对这些个体知之甚少,因为目前的评估工具和实践并不适合这一人群。更重要的是,没有模型可以解释为什么大约30%的ASD人群仍然保持最低限度的语言能力,也没有专门针对这一人群的干预措施来促进口语。我们ACE的目标是解决这些问题,从语言、听觉、临床和计算神经科学的其他领域引入工具、方法和方法。我们的ACE位于波士顿大学,汇集了来自整个大学的研究人员以及来自哈佛医学院、东北大学和爱因斯坦医学院的合作者。ACE中相互关联的项目包括:一种促进ASD学龄儿童口语的新干预(项目一);研究治疗反应和结果的生物标志物(项目I、II和III);研究可能导致说话失败的机制,包括:(a)根据DIVA模型,语音产生网络关键节点的结构和功能连接障碍(项目11);(b)电生理反应和神经振荡模式显示的听觉场景的感知、组织和分析异常(项目三);使用高分辨率方法研究组织样本中的白质和轴突生长蛋白,在与语言相关的关键前额皮质区域发现兴奋性和抑制性神经元通路的中断(项目IV)。这些项目由行政和数据管理核心(A)、研究培训和教育核心(B)和临床核心(C)联合服务,它们将使用标准和新颖的实验措施进行全面评估,以捕捉ASD患儿的异质性表型,并将用于解释项目中确定的治疗反应和机制因素的可变性。总之,我们在ACE中进行的研究将极大地促进我们对自闭症谱系中被忽视的这一部分的理解,为评估和治疗提供创新的方法,为识别生物标记铺平道路,预测谁将无法获得语言,并突出潜在的分子治疗干预目标。
项目成果
期刊论文数量(21)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
An analysis of stereotypical motor movements and cardiovascular coupling in individuals on the autism spectrum.
对自闭症谱系个体的刻板运动和心血管耦合的分析。
- DOI:10.1016/j.biopsycho.2019.01.004
- 发表时间:2019
- 期刊:
- 影响因子:2.6
- 作者:Heathers,JamesAJ;Gilchrist,KristinH;Hegarty-Craver,Meghan;Grego,Sonia;Goodwin,MatthewS
- 通讯作者:Goodwin,MatthewS
How effective is LENA in detecting speech vocalizations and language produced by children and adolescents with ASD in different contexts?
LENA 在检测自闭症儿童和青少年在不同环境中发出的言语和语言方面的效果如何?
- DOI:10.1002/aur.2071
- 发表时间:2019
- 期刊:
- 影响因子:0
- 作者:Jones,RebeccaM;PlesaSkwerer,Daniela;Pawar,Rahul;Hamo,Amarelle;Carberry,Caroline;Ajodan,ElianaL;Caulley,Desmond;Silverman,MelanieR;McAdoo,Shannon;Meyer,Steven;Yoder,Anne;Clements,Mark;Lord,Catherine;Tager-Flusberg,Helen
- 通讯作者:Tager-Flusberg,Helen
Atypical hemispheric asymmetry in the arcuate fasciculus of completely nonverbal children with autism.
- DOI:10.1111/j.1749-6632.2012.06446.x
- 发表时间:2012-04
- 期刊:
- 影响因子:5.2
- 作者:Wan CY;Marchina S;Norton A;Schlaug G
- 通讯作者:Schlaug G
Concurrent Social Communication Predictors of Expressive Language in Minimally Verbal Children and Adolescents with Autism Spectrum Disorder
- DOI:10.1007/s10803-019-04089-8
- 发表时间:2019-09-01
- 期刊:
- 影响因子:3.9
- 作者:Pecukonis, Meredith;Skwerer, Daniela Plesa;Tager-Flusberg, Helen
- 通讯作者:Tager-Flusberg, Helen
Prevalence and Correlates of Psychiatric Symptoms in Minimally Verbal Children and Adolescents With ASD.
患有自闭症谱系障碍 (ASD) 的很少言语的儿童和青少年精神症状的患病率和相关性。
- DOI:10.3389/fpsyt.2019.00043
- 发表时间:2019
- 期刊:
- 影响因子:4.7
- 作者:PlesaSkwerer,Daniela;Joseph,RobertM;Eggleston,Brady;Meyer,StevenR;Tager-Flusberg,Helen
- 通讯作者:Tager-Flusberg,Helen
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Helen Tager-Flusberg其他文献
Helen Tager-Flusberg的其他文献
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{{ truncateString('Helen Tager-Flusberg', 18)}}的其他基金
Williams Syndrome: International Scientific and Professional Conference
威廉姆斯综合症:国际科学和专业会议
- 批准号:
8319803 - 财政年份:2012
- 资助金额:
$ 185.26万 - 项目类别:
Minimally Verbal ASD: From Basic Mechanisms to Innovative Interventions
最低程度言语自闭症谱系障碍:从基本机制到创新干预措施
- 批准号:
8539761 - 财政年份:2012
- 资助金额:
$ 185.26万 - 项目类别:
Williams Syndrome: International Scientific and Professional Conference
威廉姆斯综合症:国际科学和专业会议
- 批准号:
8637104 - 财政年份:2012
- 资助金额:
$ 185.26万 - 项目类别:
Minimally Verbal ASD: From Basic Mechanisms to Innovative Interventions
最低程度言语自闭症谱系障碍:从基本机制到创新干预措施
- 批准号:
8913120 - 财政年份:2012
- 资助金额:
$ 185.26万 - 项目类别:
Williams Syndrome: International Scientific and Professional Conference
威廉姆斯综合症:国际科学和专业会议
- 批准号:
8441507 - 财政年份:2012
- 资助金额:
$ 185.26万 - 项目类别:
Williams Syndrome: International Scientific and Professional Conference
威廉姆斯综合症:国际科学和专业会议
- 批准号:
9045681 - 财政年份:2012
- 资助金额:
$ 185.26万 - 项目类别:
Minimally Verbal ASD: From Basic Mechanisms to Innovative Interventions
最低程度言语自闭症谱系障碍:从基本机制到创新干预措施
- 批准号:
8385988 - 财政年份:2012
- 资助金额:
$ 185.26万 - 项目类别:
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