Atypical hemispheric asymmetry in the arcuate fasciculus of completely nonverbal children with autism.
Atypical hemispheric asymmetry in the arcuate fasciculus of completely nonverbal children with autism.
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DOI：
10.1111/j.1749-6632.2012.06446.x
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发表时间：
2012-04
影响因子：
5.2
通讯作者：
Schlaug G
中科院分区：
文献类型：
--
作者：
Wan CY;Marchina S;Norton A;Schlaug G
尽管被诊断患有自闭症谱系障碍的儿童中有多达25%是非语言的，但令人惊讶的是，对这一群体进行的研究很少。特别是，他们缺乏语言的机制仍然不清楚。利用扩散张量成像，我们比较了5名完全不会说话的自闭症儿童和正常发育儿童的语言相关白质束(弓状束，AF)的结构。我们发现，作为一个整体，非语言儿童并没有表现出预期的左右房颤不对称--相反，五个非语言儿童中的四个实际上显示了相反的模式。这种不同寻常的不对称模式可能是自闭症患者普遍存在的一些严重语言缺陷的根源，尤其是在语言发育不全的儿童中。此外，旨在吸引通过房颤连接的大脑区域的新干预措施(如听觉-运动映射训练)可能对促进患有自闭症的非言语儿童的语言表达具有重要的临床潜力。
Despite the fact that as many as 25% of the children diagnosed with autism spectrum disorders are nonverbal, surprisingly little research has been conducted on this population. In particular, the mechanisms that underlie their absence of speech remain unknown. Using diffusion tensor imaging, we compared the structure of a language-related white matter tract (the arcuate fasciculus, AF) in five completely nonverbal children with autism to that of typically developing children. We found that, as a group, the nonverbal children did not show the expected left–right AF asymmetry—rather, four of the five nonverbal children actually showed the reversed pattern. It is possible that this unusual pattern of asymmetry may underlie some of the severe language deficits commonly found in autism, particularly in children whose speech fails to develop. Furthermore, novel interventions (such as auditory-motor mapping training) designed to engage brain regions that are connected via the AF may have important clinical potential for facilitating expressive language in nonverbal children with autism.
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