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Analysis of Lipolytic Trafficking in Adipocytes

Analysis of Lipolytic Trafficking in Adipocytes
脂肪细胞中脂解运输的分析
批准号：
9102492
负责人：
James G Granneman
金额：
$38.38万
依托单位：
WAYNE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-06-01 至 2021-03-31
来源：
https://reporter.nih.gov/project-details/9102492
关键词：
Acyl Coenzyme AAdipocytesAdipose tissueAffinity LabelsAllosteric RegulationBindingBiological AssayCardiovascular DiseasesCellsChemicalsCyclic AMP-Dependent Protein KinasesDefectDiseaseEquilibriumEukaryotic CellFatty AcidsFatty acid glycerol estersFeedbackFoundationsGoalsHeartHydrolaseImageLeadLibrariesLifeLigand BindingLigandsLinkLipaseLipid MobilizationLipidsLipolysisMalignant NeoplasmsMass Spectrum AnalysisMediatingMetabolicMetabolic DiseasesMolecularMuscleObesityOvernutritionPathway interactionsPhosphorylationProcessProductionProteinsRegulationResolutionSignal PathwaySignal TransductionSkeletal MuscleStructural ModelsSurfaceTherapeuticTissuesUnited States National Institutes of HealthWorkaffinity labelingbasechemical geneticsextracellularinsightmolecular imagingnovelnovel therapeuticsobesity treatmentperilipinpublic health relevancescreeningtooltrafficking

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中文摘要
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英文摘要
 DESCRIPTION (provided by applicant): ABHD5 is an important lipase-activating protein, but how it functions to control lipolysis is poorly understood. Screening of the NIH compound library identified compounds that directly bind and activate ABHD5 independently of known extracellular signaling pathways. By using these probes in molecular imaging assays, we discovered endogenous ligands that bind ABDH5 and regulate its lipase-promoting activity. This proposal will investigate this novel locus of lipolysis control using integrated cellular and molecular approaches. A greater understanding of how these endogenous and synthetic compounds regulate ABHD5 could lead to novel therapeutics for treatment of obesity-related disorders.
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Preclinical validation of ABHD5 as a target for treatment of obesity.
  • 批准号：
    9114105
  • 项目类别：
  • 资助金额：
    $69.55万
  • 财政年份：
    2015
  • 负责人：
    James G Granneman
  • 依托单位：
    WAYNE STATE UNIVERSITY
Preclinical validation of ABHD5 as a target for treatment of obesity.
  • 批准号：
    8940763
  • 项目类别：
  • 资助金额：
    $68.67万
  • 财政年份：
    2015
  • 负责人：
    James G Granneman
  • 依托单位：
    WAYNE STATE UNIVERSITY
Sympathetic innervation of cold-activated brown and white fat in lean young adult
  • 批准号：
    8742239
  • 项目类别：
  • 资助金额：
    $30.48万
  • 财政年份：
    2014
  • 负责人：
    James G Granneman
  • 依托单位：
    WAYNE STATE UNIVERSITY
Analysis of Lipolytic Trafficking in Muscle
  • 批准号：
    8244642
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
    2011
  • 负责人：
    James G Granneman
  • 依托单位：
    JOHN D DINGELL VA MEDICAL CENTER
国内基金
海外基金
支链氨基酸代谢紊乱调控“Adipocytes - Macrophages Crosstalk”诱发2型糖尿病脂肪组织功能和结构障碍的作用及机制