Biostatistics Core

生物统计学核心

• 批准号: 9125773
• 负责人: DIANNE M FINKELSTEIN
• 金额: $ 13.19万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-19 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9125773
• 关键词: Animals; Biostatistics Core; Clinical; Clinical Protocols; Clinical Research; Clinical Trials; Code; Collaborations; Computing Methodologies; Consult; Consultations; Core Facility; Data; Data Analyses; Data Collection; Data Set; Databases; Development; Ensure; Event; Experimental Designs; Funding; Futility; Glioma; Health; Human; Investigation; Laboratories; Laboratory Study; Manuscripts; Measurement; Medical; Methodology; Methods; Monitor; Patient Care; Patients; Preparation; Process; Research; Research Personnel; Research Support; Resources; Role; Safety; Security; Statistical Data Interpretation; Statistical Methods; Statistical Models; Time; Translating; Translations; Variant; anticancer research; cost; data management; database design; design; high standard; molecular imaging; novel; pre-clinical; preclinical study; programs; research study; symposium; targeted treatment; tissue biomarkers

The Biostatistics Core will provide statistical support for the research conducted in the Glioma SPORE program, including related database and computing requirements. The Core will provide consultation and expertise on the development and implementation of plans for data collection, particularly the coding convention and variable format required for statistical analysis. The Core will contribute to the data management plan, including form design and database requirements, during development of the SPORE-related clinical trials. The Core will provide expertise and resources for data transfer, merging, sharing and security while maintaining the confidentiality of all patient-related protected health information. The Core will provide ready and dedicated access to statistical expertise for the design, planning and conduct of preclinical experiments, clinical trials and correlative tissue and biomarker studies. Analysis of the clinical trials will include interim monitoring, if necessary, including the stopping rules for safety and futility. The Core will also provide statistical expertise for data analysis and interpretation of research studies, including manuscript preparation.

生物统计核心将为在胶质瘤孢子中进行的研究提供统计支持 程序，包括相关的数据库和计算要求。核心将提供咨询和 在制定和执行数据收集计划，特别是编码方面的专门知识 统计分析所需的约定和可变格式。核心将对数据做出贡献 管理计划，包括表格设计和数据库要求，在开发过程中与孢子相关 临床试验。该核心将为数据传输、合并、共享和 安全，同时维护所有与患者相关的受保护健康信息的机密性。核心意志 为设计、规划和实施临床前工作提供随时可用的统计专业知识 实验、临床试验和相关的组织和生物标记物研究。对临床试验的分析将 如有必要，包括临时监测，包括安全和徒劳的停车规则。核心还将 为研究研究的数据分析和解释提供统计专业知识，包括手稿 准备工作。