2016 LAM Foundation International Lymphangioleiomyomatosis Research Conference

摘要 2016 LAM基金会国际淋巴管肌瘤病研究会议将重点关注 发生在致死性肺中的平滑肌增殖和囊性肺破坏的分子机制 妇女疾病，淋巴管肌瘤病(LAM)。这是第19届LAM年会， 已经从专门的家庭/患者会议发展成为LAM和 结节性硬化症。2016年的会议将在辛辛那提举行，与罕见的肺部疾病同时举行 会议。基础科学会议将集中在淋巴管生成和淋巴成像，mTOR 信号、LAM生物标记物和以患者为中心的研究设计。更多面向临床的谈话将是 纳入大多数会议，以解决有关疾病治疗的实际挑战、问题 LAM患者移植特有的生物标志物和表型方法的开发 林遵循了从其他疾病中吸取的教训。同时举办的以患者为中心的系列研讨会将讨论 预计将出席并将参加的280名LAM患者及其家属的主要临床问题 在基础和临床田径主席的科学会议总结中达到高潮。半天林 基金会诊所主任会议将在会议的最后一天召开，讨论挑战 案例，并为网络设置优先级。每届会议将由该领域的一名专家主持，并将 特邀发言者以及从提交的摘要库中选择的发言者。有一种意识 努力吸引来自相关学科的资深调查人员，这些调查人员可以补充 目前的LAM调查员队伍。由讨论负责人主持的讨论将是一个重要组成部分 在所有的课程中。优秀初级调查人员将根据功绩获得旅行津贴，并将获得 有机会以平台和海报的形式展示他们的研究成果。这次会议的目标是 为领先的专家提供一个论坛，讨论LAM的分子和细胞基础，回顾临床 管理LAM，展示尖端研究，整合概念并确定创造性和 创新研究方向。

ABSTRACT The 2016 LAM Foundation International Lymphangioleiomyomatosis Research Conference will focus on the molecular mechanisms of smooth muscle proliferation and cystic lung destruction that occur in the fatal lung disease of women, Lymphangioleiomyomatosis (LAM). This is the nineteenth annual LAM conference, which has evolved from a dedicated family/patient conference to a state of the art scientific meeting for LAM and tuberous sclerosis. The 2016 meeting will be held in Cincinnati, in parallel with the Rare Lung Disease Conference. The basic science sessions will focus on lymphangiogenesis and lymphatic imaging, mTOR signaling, LAM biomarkers and patient centered research designs. More clinically oriented talks will be incorporated into most sessions, to address practical challenges regarding treatment of the disease, issues unique to transplantation of LAM patients and the development of biomarkers and phenotyping approaches for LAM following lessons learned from other diseases. A concurrent patient-oriented seminar series will address key clinical issues for 280 LAM patients and LAM family members who are expected to attend, and will culminate in a summary of scientific sessions by the Basic and Clinical Track Chairs. A half day LAM Foundation Clinic Directors meeting will be convened on the last day of the conference to discuss challenging cases, and set priorities for the network. Each session will be chaired by an expert in the field and will have invited speakers as well as speakers chosen from the pool of submitted abstracts. There has been a conscious effort to attract established investigators from related disciplines who can complement the expertise of the current pool of LAM investigators. Discussion facilitated by a discussion leader will be an important component of all sessions. Outstanding junior investigators will be awarded travel grants based on merit and will be given the opportunity to present their research in platform and poster formats. The goal of this conference is to provide a forum for leading experts to discuss the molecular and cellular basis of LAM, review the clinical management of LAM, to present cutting edge research, to integrate concepts and to identify creative and innovative research directions.