Training Program for Innovative Engineering Research in Surgery and Intervention

 描述(由申请人提供)：在过去的几十年里，实验室研究见证了生物医学科学的戏剧性突破。翻译这些发现以及在人类研究中做出新发现的能力一直是一个挑战，经常被描述为临床研究的瓶颈。在此背景下，医疗保健组织环境发生了巨大变化，在交付、效率和报销方面受到限制，以包括联邦和行业医疗研究投资的重大结构性变化。最后，由于医疗保健筹资结构发生了重大的系统性变化， 对高等教育毕业生，特别是博士毕业生职业生涯的影响是相当深远的。在不断变化的动态格局中，我们假设，通过对熟悉人类治疗的工程师进行培训，并在基于新技术的平台的初始阶段进行培训，可以显著缓解与临床转化研究相关的根本瓶颈。我们进一步假设，人类环境中的持续科学发现以及新的治疗方法高度依赖于这些以技术为基础的仪器平台。该培训计划的目的是培养一支能够创造、开发、实施、临床评估和翻译方法、设备、算法和系统的新的研究人员队伍，这些方法、设备、算法和系统的设计明确侧重于一种特定的医学应用，即促进手术/介入过程及其结果。在主题上，我们的学员和培训计划将有一个中心重点-治疗和发现的创新平台技术。虽然这一培训计划解决了生物医学研究中的紧迫问题，即人类调查系统的翻译和便利化，但该计划也通过提供新的职业发展氛围来改善高等教育的职业发展轨迹。简而言之，培训计划是一个2，3年的计划，最初的1年需要参加一个新的专业发展和广泛的治疗生物工程课程。随着对实习生身份的申请和接受，实习生体验到沉浸在临床环境中，包括文献回顾、需求评估和对临床治疗和发现障碍的新建议。在图像引导程序、介入成像、介入医学图像处理和分析、机器人学和医疗器械设计、建模和仿真以及介入治疗学相关领域的持续课程工作将为学员提供几乎无限的创新技术选择。这一切都发生在一个高度促进技术转让和科学发现的环境中。我们相信范德比尔特是最独特的环境之一，包括令人难以置信的近距离手术和介入套房，机器人和医疗设备制造能力，指导和分析实验室，广泛的治疗调查，成像基础设施，大型动物手术设施，以及 一位与我们的工程师一起具有开创性发明历史的临床干部。这是一个外科和介入领域创新工程研究的培训计划。

 DESCRIPTION (provided by applicant): Over the past several decades, dramatic breakthroughs in biomedical science have been witnessed within laboratory research. The ability to translate those discoveries as well as to make new discoveries within human investigations has been a challenge and has been often characterized as the bottleneck of clinical research. Added to this context has been the dramatic changes to healthcare organizational environments, constraints on delivery, efficiency, and reimbursements to include major structural changes to the investment in healthcare research, both federally, and industrially. Lastly, as a result of dramatic systemic changes in healthcare funding structure, the impact on higher educational graduates' careers, specifically doctoral graduates, has been quite profound. Within that changing dynamic landscape, we hypothesize that the fundamental bottlenecks associated with clinical translational research can be dramatically loosened with the training of engineers intimately familiar with human treatment and trained in the inception of novel technology-based platforms. We further hypothesize that continued scientific discoveries within the human environment as well as novel treatment approaches are highly dependent on these technology-based instrumentation platforms. The purpose of this training program is to create a new cadre of researchers capable of creating, developing, implementing, clinically evaluating, and translating methods, devices, algorithms, and systems designed with a clear focus at one particular application of medicine, namely, to facilitate surgical/interventional processes and their outcomes. Thematically, our trainees and training program will have a central focus - innovative platform technologies for treatment and discovery. While this training program addresses pressing problems in biomedical research, namely the translation and facilitation of human investigative systems, the program also speaks to improving higher education career trajectories by providing a novel professional development atmosphere. Briefly described, the training program is a year 2, 3 program with an initial year 1 requiring participation in a novel professional development and a broad therapeutic bioengineering course. With application and acceptance to trainee status, trainees experience an immersion in the clinical environment involving literature reviews, needs assessments, and novel proposals to clinical barriers towards treatment and discovery. Continued course work in areas associated with image-guided procedures, interventional imaging, interventional medical image processing and analysis, robotics and medical device design, modeling & simulation, and interventional therapeutics will provide trainees with almost limitless options for the creation of novel technologies. This all takes place within an environment that is highly promoting of technology transfer as well as scientific discovery. We believe Vanderbilt to be one of the most unique environments that includes incredible close proximity of surgical and interventional suites, robotic and medical device fabrication capabilities, guidance and analysis laboratories, extensive therapeutic investigations, imaging infrastructure, large animal surgical facilities, and a clinical cadre with a history of pioneering invention with our engineers. This is a Training Program for Innovative Engineering Research in Surgery and Intervention.