Lab-on-a-Chip-Based System for Detection and Monitoring of Oral Cancer in Dental Settings

用于牙科环境中口腔癌检测和监测的基于芯片实验室的系统

基本信息

  • 批准号:
    9047158
  • 负责人:
  • 金额:
    $ 22.5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-05-01 至 2017-02-28
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): Cancers of the oral cavity and pharynx are among the most serious cancers, with approximately 400,000 incidents globally. In the US, the 5-year survival rate is approximately 64% among the lowest for all forms of cancer. Yet when diagnosed in the early stages with confinement to the primary site, the rate increases dramatically to about 83%. Further, cancers of the oral cavity are among the most expensive to treat due to the fact that approximately two-thirds of oral and pharyngeal cancers are advanced at the time of diagnosis. Until now, scalpel biopsy has been the only reliable means of accurately assessing suspicious oral lesions. To address these significant clinical gaps, SensoDx will target the development and commercialization of the OraTechTM technology for use as adjunctive diagnostic aids for the diagnosis of potentially malignant oral lesions. This new approach will combine a noninvasive oral brush sampling methodology, a microfluidic cell capture cartridge, an assay platform and an analyzer system. This state-of-the-art automated miniaturized cytology system will be used to reveal cell morphometrics and protein expression values (cell surface markers and intracellular markers) to identify the patients with a subset of potentially malignant oral lesions that require follow up scalpel biopsy. Diagnostic models based on biomarker data derived from these powerful chip-based tools, alongside lesion characteristics obtained from a customized mHealth App will allow for an elegant data fusion process to occur whereby lesion characteristics, risk factors and the numerous cytology factors yield the desperately needed clinical insights for patients suffering from oral cancer. This Fast Track SBIR submission will include two major segments. In the first phase, the specifications for the scalable cartridges will be defined and protocols established for high reproducibility single cell measurements. Commercial imaging instrumentation and software will also be developed during this time period. In the second major phase, the consumables will be scaled, manufacturing processes will be developed and the instrumentation and cartridges will be validated using banked specimens. The key technical objectives for the effort are as follows: 1. To design and develop unique microfluidics-based cartridges that are suitable for capture and completion of single-cell assays as promoted by a minimally-invasive brush sampling device. 2. To define optimal sample collection and shipping protocols suitable for high quality single cell assays. 3. To establish specifications for the cartridge and to define manufacturing methods that enable volume production of cartridges, analyzer instrumentation, and control-analysis software. 4. To develop a mHealth tool that allows for the seamless pairing of brush biopsy specimens with lesion photos thereby fostering a data fusion that enhances the performance of this noninvasive test modality.


项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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JOHN T MCDEVITT其他文献

JOHN T MCDEVITT的其他文献

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{{ truncateString('JOHN T MCDEVITT', 18)}}的其他基金

Oral Dysplasia and Oral Cavity Cancer Risk in Dental and Medical Surveillance Settings Using a Chairside Chip-Based Cytopathology Tool
使用基于椅旁芯片的细胞病理学工具评估牙科和医疗监测环境中的口腔发育不良和口腔癌风险
  • 批准号:
    10344966
  • 财政年份:
    2022
  • 资助金额:
    $ 22.5万
  • 项目类别:
Oral Dysplasia and Oral Cavity Cancer Risk in Dental and Medical Surveillance Settings Using a Chairside Chip-Based Cytopathology Tool
使用基于椅旁芯片的细胞病理学工具评估牙科和医疗监测环境中的口腔发育不良和口腔癌风险
  • 批准号:
    10605157
  • 财政年份:
    2022
  • 资助金额:
    $ 22.5万
  • 项目类别:
Lab-on-a-Chip-Based System for Detection and Monitoring of Oral Cancer in Dental Settings
用于牙科环境中口腔癌检测和监测的基于芯片实验室的系统
  • 批准号:
    9387924
  • 财政年份:
    2016
  • 资助金额:
    $ 22.5万
  • 项目类别:
Monitoring of Oral Cancer Patients Using Novel Lab-on-a-Chip Ensembles
使用新型芯片实验室整体监测口腔癌患者
  • 批准号:
    8299835
  • 财政年份:
    2009
  • 资助金额:
    $ 22.5万
  • 项目类别:
Monitoring of Oral Cancer Patients Using Novel Lab-on-a-Chip Ensembles
使用新型芯片实验室整体监测口腔癌患者
  • 批准号:
    7939647
  • 财政年份:
    2009
  • 资助金额:
    $ 22.5万
  • 项目类别:
Monitoring of Oral Cancer Patients Using Novel Lab-on-a-Chip Ensembles
使用新型芯片实验室整体监测口腔癌患者
  • 批准号:
    7854787
  • 财政年份:
    2009
  • 资助金额:
    $ 22.5万
  • 项目类别:
Monitoring of Oral Cancer Patients Using Novel Lab-on-a-Chip Ensembles
使用新型芯片实验室整体监测口腔癌患者
  • 批准号:
    8521443
  • 财政年份:
    2009
  • 资助金额:
    $ 22.5万
  • 项目类别:
Development of A Lab-on-a-Chip System for Saliva-Based Diagnostics
开发基于唾液的诊断芯片实验室系统
  • 批准号:
    7151281
  • 财政年份:
    2006
  • 资助金额:
    $ 22.5万
  • 项目类别:
Development of A Lab-on-a-Chip System for Saliva-Based Diagnostics
开发基于唾液的诊断芯片实验室系统
  • 批准号:
    7282487
  • 财政年份:
    2006
  • 资助金额:
    $ 22.5万
  • 项目类别:
Development of A Lab-on-a-Chip System for Saliva-Based Diagnostics
开发基于唾液的诊断芯片实验室系统
  • 批准号:
    7919019
  • 财政年份:
    2006
  • 资助金额:
    $ 22.5万
  • 项目类别:

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