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NICHD Maternal Fetal Medicine Units Network

NICHD 母胎医学单位网络

基本信息

批准号：
9075826
负责人：
SAMUEL I. PARRY
金额：
$ 30.54万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-04-01 至 2021-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9075826
关键词：
Address Back Bar Codes Bioenergetics Biology Caring Cervix Uteri Clinical Research Clinical Trials Collection Controlled Clinical Trials Data Data Quality Databases Discipline of obstetrics Double-Blind Method Enrollment Environment Fetus Floor Funding Genetic Genomics Gynecology Health system Hereditary Disease High-Risk Pregnancy Hospitals Inpatients Lead Leadership Manuals Maternal and Child Health Maternal-Fetal Medicine Units Network Modeling Multicenter Neonatal Research Network Multicenter Studies Multicenter Trials National Institute of Child Health and Human Development Neonatal Observational Study Outpatients Participant Patient Recruitments Pediatric Hospitals Pennsylvania Performance Philadelphia Placebo Control Placenta Population Positioning Attribute Pregnancy Premature Birth Process Proteomics Protocols documentation Publications Randomized Recruitment Activity Research Research Infrastructure Research Personnel Research Project Grants Role Second Labor Stage Services Site Technology Time Translational Research United States National Institutes of Health Universities University Hospitals Woman Work clinical research site cohort collaborative environment design experience fetal medicine follow-up gut microbiome high risk implementation research improved improved outcome intrapartum meetings metabolomics neonatal outcome operation patient population perinatal medicine premature programs public health relevance racial and ethnic reproductive research study screening smoking cessation vaginal microbiome

项目摘要

DESCRIPTION (provided by applicant): The University of Pennsylvania's Department of Obstetrics and Gynecology reflects a long tradition of excellence in clinical and translational research. The Division of Maternal-Fetal Medicine (MFM) and its Maternal and Child Health Research Program (MCHRP) have been key participants in this tradition. In this application, information is provided on the obstetrical service and the proven track record for conducting clinical research at the two hospitals in the University of Pennsylvania Health System (Penn) - the Hospital of the University of Pennsylvania (HUP) and Pennsylvania Hospital (PAH) - which are proposed sites of patient recruitment for this Maternal-Fetal Medicine Units (MFMU) Network application. Each year, approximately 9,000 women are delivered at Penn, and many of these women are documented to be high-risk pregnancies. The obstetric population at Penn also has a diverse racial and ethnic background, which will be an important asset for enrollment in MFMU studies. The proposed MFMU site at Penn will operate within the highly successful MCHRP, which offers continuous enrollment (24/7) into antepartum and intrapartum research studies, outpatient recruitment at all major clinical sites at HUP and PAH, and established protocols for biospecimen collection and databanking. The MCHRP coordinators work closely with coordinators from the Neonatal Research Network at Penn to provide neonatal follow-up. The MCHRP was critical for the successful enrollment of 1,100 women into the nuMoM2b Network study at Penn (U01-HD05088), and the MCHRP is a key asset for the recently designated March of Dimes Center for Prematurity Research at Penn. The investigative team proposed for the MFMU site at Penn has significant experience directing multicenter studies, and each investigator has an exciting research agenda that will add unique perspectives to the MFMU Network. The investigators have a proven track record studying preterm birth; placental biology; genomics, proteomics, and metabolomics; vaginal and gut microbiome; maternal screening for genetic disorders; and models of obstetrical care. The proposed investigators recognize several key specific aims of this application: 1) To aid in the identification of the highest priority issues for research in perinatal medicine; 2) To work within the collaborative environment of the MFMU Network toward the design and implementation of research projects that address high priority issues; 3) To provide the highest quality data for MFMU studies and to provide these data in a timely fashion; and 4) To be involved in the analysis and publication of studies performed by the MFMU Network. The research environment in the Department of Obstetrics and Gynecology at Penn is exciting and continually growing, and the proposed leadership team reflects a strong commitment for full engagement by the department in the MFMU Network. The investigators will be able to leverage the infrastructure of existing programs to develop a successful MFMU site at Penn that meets and/or exceeds all objectives of the four specific aims proposed in this application.