NICHD Maternal Fetal Medicine Units Network

NICHD 母胎医学单位网络

基本信息

批准号：
9075826
负责人：
SAMUEL I. PARRY
金额：
$ 30.54万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-04-01 至 2021-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9075826
关键词：
Address Back Bar Codes Bioenergetics Biology Caring Cervix Uteri Clinical Research Clinical Trials Collection Controlled Clinical Trials Data Data Quality Databases Discipline of obstetrics Double-Blind Method Enrollment Environment Fetus Floor Funding Genetic Genomics Gynecology Health system Hereditary Disease High-Risk Pregnancy Hospitals Inpatients Lead Leadership Manuals Maternal and Child Health Maternal-Fetal Medicine Units Network Modeling Multicenter Neonatal Research Network Multicenter Studies Multicenter Trials National Institute of Child Health and Human Development Neonatal Observational Study Outpatients Participant Patient Recruitments Pediatric Hospitals Pennsylvania Performance Philadelphia Placebo Control Placenta Population Positioning Attribute Pregnancy Premature Birth Process Proteomics Protocols documentation Publications Randomized Recruitment Activity Research Research Infrastructure Research Personnel Research Project Grants Role Second Labor Stage Services Site Technology Time Translational Research United States National Institutes of Health Universities University Hospitals Woman Work clinical research site cohort collaborative environment design experience fetal medicine follow-up gut microbiome high risk implementation research improved improved outcome intrapartum meetings metabolomics neonatal outcome operation patient population perinatal medicine premature programs public health relevance racial and ethnic reproductive research study screening smoking cessation vaginal microbiome

项目摘要

DESCRIPTION (provided by applicant): The University of Pennsylvania's Department of Obstetrics and Gynecology reflects a long tradition of excellence in clinical and translational research. The Division of Maternal-Fetal Medicine (MFM) and its Maternal and Child Health Research Program (MCHRP) have been key participants in this tradition. In this application, information is provided on the obstetrical service and the proven track record for conducting clinical research at the two hospitals in the University of Pennsylvania Health System (Penn) - the Hospital of the University of Pennsylvania (HUP) and Pennsylvania Hospital (PAH) - which are proposed sites of patient recruitment for this Maternal-Fetal Medicine Units (MFMU) Network application. Each year, approximately 9,000 women are delivered at Penn, and many of these women are documented to be high-risk pregnancies. The obstetric population at Penn also has a diverse racial and ethnic background, which will be an important asset for enrollment in MFMU studies. The proposed MFMU site at Penn will operate within the highly successful MCHRP, which offers continuous enrollment (24/7) into antepartum and intrapartum research studies, outpatient recruitment at all major clinical sites at HUP and PAH, and established protocols for biospecimen collection and databanking. The MCHRP coordinators work closely with coordinators from the Neonatal Research Network at Penn to provide neonatal follow-up. The MCHRP was critical for the successful enrollment of 1,100 women into the nuMoM2b Network study at Penn (U01-HD05088), and the MCHRP is a key asset for the recently designated March of Dimes Center for Prematurity Research at Penn. The investigative team proposed for the MFMU site at Penn has significant experience directing multicenter studies, and each investigator has an exciting research agenda that will add unique perspectives to the MFMU Network. The investigators have a proven track record studying preterm birth; placental biology; genomics, proteomics, and metabolomics; vaginal and gut microbiome; maternal screening for genetic disorders; and models of obstetrical care. The proposed investigators recognize several key specific aims of this application: 1) To aid in the identification of the highest priority issues for research in perinatal medicine; 2) To work within the collaborative environment of the MFMU Network toward the design and implementation of research projects that address high priority issues; 3) To provide the highest quality data for MFMU studies and to provide these data in a timely fashion; and 4) To be involved in the analysis and publication of studies performed by the MFMU Network. The research environment in the Department of Obstetrics and Gynecology at Penn is exciting and continually growing, and the proposed leadership team reflects a strong commitment for full engagement by the department in the MFMU Network. The investigators will be able to leverage the infrastructure of existing programs to develop a successful MFMU site at Penn that meets and/or exceeds all objectives of the four specific aims proposed in this application.

描述（由应用程序提供）：宾夕法尼亚大学的妇产科妇产科系反映了悠久的临床和翻译研究卓越传统。孕产妇医学（MFM）及其孕产妇和儿童健康研究计划（MCHRP）的部门一直是这一传统的关键参与者。在此应用程序中，提供了有关产科服务的信息以及在宾夕法尼亚大学卫生系统（Penn）的两家医院进行临床研究的良好记录，宾夕法尼亚大学（HUP）和宾夕法尼亚大学医院和宾夕法尼亚州医院（PAH）（PAH）（PAH）（PAH） - 这是该Maternalnal -Fetal -Fetal -Fetal -Fetal -Fetal -fetal -necterment internation nection necternal -Fertal -Fetal -fetal -fetal -fetal -unite nimut intal -fetal -fetal -fetal -un。每年，宾夕法尼亚州约有9,000名妇女分娩，其中许多妇女被记录为高风险妊娠。宾夕法尼亚州的产科人口也具有多样性的种族和种族背景，这将是参加MFMU研究的重要资产。宾夕法尼亚州提出的MFMU站点将在非常成功的MCHRP内运行，该网站将在HUP和PAH的所有主要临床场所提供持续入学（24/7），并在所有主要临床场所招募了门诊，并建立了生物生物生物生物生物生物生物的收集和数据储备方案。 MCHRP协调员与宾夕法尼亚州新生儿研究网络的协调员密切合作，以提供新生儿随访。 MCHRP对于成功入学1,100名妇女进入宾夕法尼亚州的NUMOM2B网络研究（U01-HD05088）至关重要，而MCHRP是最近指定的Dimes早产中心研究中心宾夕法尼亚州早产中心的关键资产。宾夕法尼亚州MFMU网站提出的调查团队具有指导多中心研究的丰富经验，每个研究者都有一个令人兴奋的研究议程，将为MFMU网络增加独特的观点。调查人员有一个可靠的记录研究早产；斑点生物学；基因组学，蛋白质组学和代谢组学；阴道和肠道微生物组；孕产妇筛查遗传疾病；和产科护理的模型。拟议的调查人员认识到本申请的几个关键目的：1）帮助识别围产期医学研究的最高优先级问题； 2）在MFMU网络的协作环境中工作，以设计和实施解决高优先事项问题的研究项目； 3）为MFMU研究提供最高质量的数据并及时提供这些数据； 4）参与MFMU网络进行的研究分析和发布。宾夕法尼亚州的妇产科研究环境令人兴奋且不断增长，拟议的领导团队反映了该部门在MFMU网络中充分参与的坚定承诺。调查人员将能够利用现有计划的基础架构在Penn开发成功的MFMU网站，该网站符合和/或超过本应用程序中提出的四个特定目标的所有目标。