NICHD Maternal-Fetal Medicine Units (MFMU) Network: Clinical Center
NICHD 母胎医学单位 (MFMU) 网络:临床中心
基本信息
- 批准号:10680961
- 负责人:
- 金额:$ 35.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-04-01 至 2030-03-31
- 项目状态:未结题
- 来源:
- 关键词:Ancillary StudyAreaBiological Specimen BanksCaringClinicalClinical DataClinical ResearchClinical TrialsClinical Trials NetworkCollaborationsCollectionComputerized Medical RecordConduct Clinical TrialsDataDevelopmentDiscipline of obstetricsDisparityEnrollmentEnsureEnvironmentEquityEthnic OriginFacultyFetusFunctional disorderFundingGeneticGenomicsGoalsGood Clinical PracticeGynecologyHealth systemHeartHigh-Risk PregnancyHospitalsHypertensionIntervention StudiesLeadershipLongterm Follow-upManualsMaternal and Child HealthMaternal-Fetal Medicine Units NetworkMaternal-fetal medicineMedical RecordsModelingMulticenter Neonatal Research NetworkMulticenter StudiesMulticenter TrialsNational Institute of Child Health and Human DevelopmentNeonatalNetwork InfrastructureNursesObservational StudyOperations ResearchOutpatientsPatientsPediatric HospitalsPennsylvaniaPerformancePersonsPhasePhiladelphiaPopulationPopulation HeterogeneityPositioning AttributePost-Acute Sequelae of SARS-CoV-2 InfectionPostpartum HypertensionPostpartum WomenPregnant WomenPremature BirthProteomicsProtocols documentationPublicationsPublishingRegistered nurseRegulatory AffairsResearchResearch InfrastructureResearch PersonnelSecond Labor StageShapesSiteTextTranslational ResearchUnited States Dept. of Health and Human ServicesUnited States National Institutes of HealthUniversitiesUniversity HospitalsWomen&aposs HealthWorkWritingclinical centerclinical research sitecohortdata accessdata repositorydata sharingdisparity reductionexperiencefollow-uphigh riskimprovedimproved outcomeinnovationmaternal outcomeneonatal outcomeobstetric servicesoperationparticipant enrollmentpatient populationpregnantprematureprogramsracial diversityrandomized trialrandomized, clinical trialsrecruitreproductiveshared databasesupport network
项目摘要
Abstract
The University of Pennsylvania's Department of Obstetrics and Gynecology reflects a long tradition of
excellence in clinical and translational research. In this application, information is provided on the obstetrical
service and proven track record for conducting clinical trials at two hospitals in the University of Pennsylvania
(Penn) Health System – the Hospital of the University of Pennsylvania (HUP) and Pennsylvania Hospital
(PAH). Each year, approximately 9,500 patients are delivered at Penn, and many of these patients have high-
risk pregnancies. The obstetric population at Penn has a diverse racial and ethnic background, which is an
important asset for enrollment in Maternal-Fetal Medicine Units (MFMU) Network studies. Key assets of the
MFMU Network site at Penn are: 1) an experienced Nurse Coordinator who oversees all the clinical studies; 2)
a second registered nurse who is critical for completion of complicated Network studies (e.g., PACT, PASC-
PREG); 3) a biospecimens technician who has written manuals of operation and oversees collection,
processing, and data banking for biospecimens; 4) successful outpatient recruitment at all major clinical sites
at HUP and PAH; 5) the ability to expand to a 24/7 model that provides coverage on the labor and delivery
units at HUP and PAH; 6) data abstraction manuals for each MFMU Network study that ensure accurate
ascertainment of clinical data from the electronic medical record; and 7) support by the MFM Research
Program and the Women's Health Clinical Research Center at Penn, which assist the MFMU Network team
with recruitment of new staff, onboarding, regulatory affairs, and good clinical practices in all research
operations. The MFMU Network research team works closely with the Neonatal Research Network clinical
center at the Children's Hospital of Philadelphia to provide neonatal follow-up for MFMU Network studies. The
investigative team for the MFMU Network clinical center at Penn has substantial experience directing
multicenter studies, and each investigator has an exciting research agenda that adds unique perspectives to
the MFMU Network. The investigators propose three specific aims for this application: 1) Develop and
implement MFMU Network protocols, including recruitment, study interventions, and follow-up
examinations; 2) Provide the highest quality data for MFMU Network studies and provide these data in
a timely fashion; and 3) Collaborate with the other MFMU Network centers to identify areas for potential
research and to analyze and publish studies performed by the MFMU Network. The investigative team at
Penn has built a highly successful MFMU Network clinical site that will support the NICHD's guiding principles
shaping the 21st century landscape for multi-site clinical research, including enhanced rigor for selecting
studies, availability of Network infrastructure to a wider range of investigators, data sharing and access to
biospecimens, and inclusion of diverse populations in Network studies.
摘要
宾夕法尼亚大学的妇产科反映了一个悠久的传统
在临床和翻译研究方面表现出色。在本申请中,提供了关于产科的信息
在宾夕法尼亚大学两家医院进行临床试验的服务和经过证明的跟踪记录
(宾夕法尼亚)卫生系统-宾夕法尼亚大学医院(HUP)和宾夕法尼亚医院
(PAH)。每年,宾夕法尼亚大学大约有9500名患者接生,其中许多患者患有高-
怀孕的风险。宾夕法尼亚大学的产科人口有不同的种族和民族背景,这是一个
参加母婴医学部(MFMU)网络研究的重要资产。公司的主要资产
宾夕法尼亚大学的MFMU网络站点有:1)一名经验丰富的护士协调员,负责监督所有临床研究;2)
对完成复杂网络研究至关重要的第二名注册护士(例如,PACT、PASC-
PRIG);3)编写操作手册并监督收集的生物检验技术员,
生物标本的处理和数据库;4)在所有主要临床地点成功招募门诊病人
在HUP和PAH;5)能够扩展到全天候模式,提供对分娩和分娩的覆盖
HUP和PAH的单位;6)每个MFMU网络研究的数据摘要手册,确保准确
从电子病历中确定临床数据;以及7)MFM Research的支持
项目和宾夕法尼亚大学妇女健康临床研究中心,协助MFMU网络团队
在所有研究中招募新员工、入职、监管事务和良好的临床实践
行动。MFMU网络研究团队与新生儿研究网络临床密切合作
费城儿童医院中心为MFMU网络研究提供新生儿随访。这个
宾夕法尼亚大学MFMU网络临床中心的调查团队拥有丰富的指导经验
多中心研究,每个研究人员都有令人兴奋的研究议程,为
MFMU网络。研究人员为这一应用程序提出了三个具体目标:1)开发和
实施MFMU网络协议,包括招募、研究干预和后续行动
检查;2)为MFMU网络研究提供最高质量的数据,并在
及时;以及3)与其他MFMU网络中心合作,确定潜在的领域
研究并分析和发表由MFMU网络进行的研究。调查小组在
宾夕法尼亚大学已经建立了一个非常成功的MFMU网络临床网站,将支持NICHD的指导原则
塑造21世纪多地点临床研究的格局,包括提高选择的严谨性
研究、向更广泛的调查人员提供网络基础设施、数据共享和访问
生物群落,以及在网络研究中纳入不同的种群。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
SAMUEL I. PARRY其他文献
SAMUEL I. PARRY的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('SAMUEL I. PARRY', 18)}}的其他基金
Clinical Centers for Completion of Ongoing MFMU Network Protocols
完成正在进行的 MFMU 网络协议的临床中心
- 批准号:
10254043 - 财政年份:2016
- 资助金额:
$ 35.75万 - 项目类别:
Clinical Centers for Completion of Ongoing MFMU Network Protocols
完成正在进行的 MFMU 网络协议的临床中心
- 批准号:
10379414 - 财政年份:2016
- 资助金额:
$ 35.75万 - 项目类别:
Pregnancy as a Window to Future Cardiovascular Health
怀孕是未来心血管健康的窗口
- 批准号:
8723289 - 财政年份:2013
- 资助金额:
$ 35.75万 - 项目类别:
Pregnancy as a Window to Future Cardiovascular Health
怀孕是未来心血管健康的窗口
- 批准号:
9061818 - 财政年份:2013
- 资助金额:
$ 35.75万 - 项目类别:
Pregnancy as a Window to Future Cardiovascular Health
怀孕是未来心血管健康的窗口
- 批准号:
8576079 - 财政年份:2013
- 资助金额:
$ 35.75万 - 项目类别:
Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk
未产妇早产:未充分研究的高危人群
- 批准号:
8605891 - 财政年份:2010
- 资助金额:
$ 35.75万 - 项目类别:
Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk
未产妇早产:未充分研究的高危人群
- 批准号:
7790992 - 财政年份:2010
- 资助金额:
$ 35.75万 - 项目类别:
Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk
未产妇早产:未充分研究的高危人群
- 批准号:
8013031 - 财政年份:2010
- 资助金额:
$ 35.75万 - 项目类别:
相似国自然基金
层出镰刀菌氮代谢调控因子AreA 介导伏马菌素 FB1 生物合成的作用机理
- 批准号:2021JJ40433
- 批准年份:2021
- 资助金额:0.0 万元
- 项目类别:省市级项目
寄主诱导梢腐病菌AreA和CYP51基因沉默增强甘蔗抗病性机制解析
- 批准号:32001603
- 批准年份:2020
- 资助金额:24.0 万元
- 项目类别:青年科学基金项目
AREA国际经济模型的移植.改进和应用
- 批准号:18870435
- 批准年份:1988
- 资助金额:2.0 万元
- 项目类别:面上项目
相似海外基金
Onboarding Rural Area Mathematics and Physical Science Scholars
农村地区数学和物理科学学者的入职
- 批准号:
2322614 - 财政年份:2024
- 资助金额:
$ 35.75万 - 项目类别:
Standard Grant
Point-scanning confocal with area detector
点扫描共焦与区域检测器
- 批准号:
534092360 - 财政年份:2024
- 资助金额:
$ 35.75万 - 项目类别:
Major Research Instrumentation
TRACK-UK: Synthesized Census and Small Area Statistics for Transport and Energy
TRACK-UK:交通和能源综合人口普查和小区域统计
- 批准号:
ES/Z50290X/1 - 财政年份:2024
- 资助金额:
$ 35.75万 - 项目类别:
Research Grant
Wide-area low-cost sustainable ocean temperature and velocity structure extraction using distributed fibre optic sensing within legacy seafloor cables
使用传统海底电缆中的分布式光纤传感进行广域低成本可持续海洋温度和速度结构提取
- 批准号:
NE/Y003365/1 - 财政年份:2024
- 资助金额:
$ 35.75万 - 项目类别:
Research Grant
Collaborative Research: Scalable Manufacturing of Large-Area Thin Films of Metal-Organic Frameworks for Separations Applications
合作研究:用于分离应用的大面积金属有机框架薄膜的可扩展制造
- 批准号:
2326714 - 财政年份:2024
- 资助金额:
$ 35.75万 - 项目类别:
Standard Grant
Collaborative Research: Scalable Manufacturing of Large-Area Thin Films of Metal-Organic Frameworks for Separations Applications
合作研究:用于分离应用的大面积金属有机框架薄膜的可扩展制造
- 批准号:
2326713 - 财政年份:2024
- 资助金额:
$ 35.75万 - 项目类别:
Standard Grant
Unlicensed Low-Power Wide Area Networks for Location-based Services
用于基于位置的服务的免许可低功耗广域网
- 批准号:
24K20765 - 财政年份:2024
- 资助金额:
$ 35.75万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
RAPID: Collaborative Research: Multifaceted Data Collection on the Aftermath of the March 26, 2024 Francis Scott Key Bridge Collapse in the DC-Maryland-Virginia Area
RAPID:协作研究:2024 年 3 月 26 日 DC-马里兰-弗吉尼亚地区 Francis Scott Key 大桥倒塌事故后果的多方面数据收集
- 批准号:
2427233 - 财政年份:2024
- 资助金额:
$ 35.75万 - 项目类别:
Standard Grant
RAPID: Collaborative Research: Multifaceted Data Collection on the Aftermath of the March 26, 2024 Francis Scott Key Bridge Collapse in the DC-Maryland-Virginia Area
RAPID:协作研究:2024 年 3 月 26 日 DC-马里兰-弗吉尼亚地区 Francis Scott Key 大桥倒塌事故后果的多方面数据收集
- 批准号:
2427232 - 财政年份:2024
- 资助金额:
$ 35.75万 - 项目类别:
Standard Grant
RAPID: Collaborative Research: Multifaceted Data Collection on the Aftermath of the March 26, 2024 Francis Scott Key Bridge Collapse in the DC-Maryland-Virginia Area
RAPID:协作研究:2024 年 3 月 26 日 DC-马里兰-弗吉尼亚地区 Francis Scott Key 大桥倒塌事故后果的多方面数据收集
- 批准号:
2427231 - 财政年份:2024
- 资助金额:
$ 35.75万 - 项目类别:
Standard Grant