In vivo imaging of destructive processes in COPD

COPD 破坏过程的体内成像

基本信息

项目摘要

 DESCRIPTION (provided by applicant): Chronic obstructive pulmonary disease (COPD) is the third leading cause of death and is characterized by clinical symptoms and spirometry. Additional measures for diagnosis can be taken using imaging modalities such as CT. However, the evaluation of lung destruction in COPD is limited by the inability to visualize the activation f pathological processes since imaging modalities are only able to evaluate end-organ damage. In this proposal, we aim to develop molecular imaging probes to target two critical processes in the initiation and progression of COPD. Apoptosis, a process of programmed cellular death, correlates with COPD severity and is not seen in the normal adult lung or in the lungs of smokers without COPD. In the past several years we have demonstrated the successful ability of AxV-128/99mTc to detect apoptosis in vivo in a rabbit smoke exposure emphysema model. Additionally, Phase 1 studies have demonstrated safety of this agent in healthy patients. Therefore, in the first two aims of this proposal we will bring to the clinic AxV-128/99mTc, an Annexin V targeted SPECT/CT imaging probe, to image disease in patients with COPD. In the first Aim we will determine whether the use of AxV-128/99mTc allows the imaging of apoptosis in patients with COPD. In the second Aim we will determine if AxV-128/99mTc SPECT-CT imaging identifies peri-operative lung injury in patients with COPD compared to individuals without COPD. In a third aim, we will develop a new matrix metalloproteinase (MMP) targeted imaging agent. Although apoptosis is an important component of COPD pathogenesis, MMP production is fundamental to the process of lung destruction. Therefore, in this final aim we will perform preclinical studies with an MMP probe in order to detect the presence of MMPs in vivo. It is our hypothesis that the development an MMP probe would complement imaging of apoptosis in a COPD patient population. If successful, such an approach will be a powerful tool to potentially predict disease progression after diagnosis, identify patients at risk for disease exacerbation related lung function decline, and monitor response to disease targeted therapy. (End of Abstract)


项目成果

期刊论文数量(0)
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Jeanine M D'Armiento其他文献

Jeanine M D'Armiento的其他文献

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{{ truncateString('Jeanine M D'Armiento', 18)}}的其他基金

Molecular Biomarkers in pathogenesis of Lymphangioleiomyomatosis (LAM)
淋巴管平滑肌瘤病 (LAM) 发病机制中的分子生物标志物
  • 批准号:
    10745193
  • 财政年份:
    2023
  • 资助金额:
    $ 70.28万
  • 项目类别:
Alpha-1 Antitrypsin Disease Cohort: Longitudinal Biomarker Study of Disease
Alpha-1 抗胰蛋白酶疾病队列:疾病的纵向生物标志物研究
  • 批准号:
    10514976
  • 财政年份:
    2020
  • 资助金额:
    $ 70.28万
  • 项目类别:
Alpha-1 Antitrypsin Disease Cohort: Longitudinal Biomarker Study of Disease
Alpha-1 抗胰蛋白酶疾病队列:疾病的纵向生物标志物研究
  • 批准号:
    10210437
  • 财政年份:
    2020
  • 资助金额:
    $ 70.28万
  • 项目类别:
Alpha-1 Antitrypsin Disease Cohort: Longitudinal Biomarker Study of Disease
Alpha-1 抗胰蛋白酶疾病队列:疾病的纵向生物标志物研究
  • 批准号:
    10686063
  • 财政年份:
    2020
  • 资助金额:
    $ 70.28万
  • 项目类别:
In vivo imaging of destructive processes in COPD
COPD 破坏过程的体内成像
  • 批准号:
    9354510
  • 财政年份:
    2016
  • 资助金额:
    $ 70.28万
  • 项目类别:
Targeting matrix metalloproteinases to limit immunopathology in airborne infectio
靶向基质金属蛋白酶以限制空气传播感染的免疫病理学
  • 批准号:
    8391388
  • 财政年份:
    2012
  • 资助金额:
    $ 70.28万
  • 项目类别:
Imaging RAGE Pro-inflammatory Signaling and Cellular Apoptosis in Emphysema
肺气肿中 RAGE 促炎信号传导和细胞凋亡的成像
  • 批准号:
    8681510
  • 财政年份:
    2012
  • 资助金额:
    $ 70.28万
  • 项目类别:
Targeting matrix metalloproteinases to limit immunopathology in airborne infectio
靶向基质金属蛋白酶以限制空气传播感染的免疫病理学
  • 批准号:
    8509565
  • 财政年份:
    2012
  • 资助金额:
    $ 70.28万
  • 项目类别:
Imaging RAGE Pro-inflammatory Signaling and Cellular Apoptosis in Emphysema
肺气肿中 RAGE 促炎信号传导和细胞凋亡的成像
  • 批准号:
    8417062
  • 财政年份:
    2012
  • 资助金额:
    $ 70.28万
  • 项目类别:
Imaging RAGE Pro-inflammatory Signaling and Cellular Apoptosis in Emphysema
肺气肿中 RAGE 促炎信号传导和细胞凋亡的成像
  • 批准号:
    8550823
  • 财政年份:
    2012
  • 资助金额:
    $ 70.28万
  • 项目类别:

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