Comparative Modeling of Colorectal Cancer: Informing Health Policies and Prioritizing Future Research

 描述(申请人提供)：结直肠癌(CRC)是美国癌症死亡的第二大原因。我们拟议项目的长期目标是通过提供解决关键政策问题和确定未来研究优先次序所需的信息，减轻儿童权利公约的人口负担。为了实现这一目标，我们将使用我们的基于人口的微观模拟模型来：1)为整个CRC控制范围内的卫生政策中新出现的问题提供信息；2)使用信息价值(VOI)框架指导CRC研究优先事项和研究设计；以及3)与利益相关者合作，培训建模人员，并促进模型的透明度，以确保现在和未来对CRC控制措施的高质量评估。我们的团队将填补知识的关键空白，使决策者能够采取行动。知识方面的重要差距包括：筛查和治疗过程失败对结直肠癌负担的影响；根据现有的风险分层工具，安全地降低一些患者的筛查和监测强度的可能性；基于患者水平信息的新的有针对性的筛查方法的潜在益处(即“精确医学”)；以及临床处理微小息肉的重要性。三个参与的建模小组能够很好地开展这项工作，在与结直肠癌微观模拟建模相关的问题上带来了丰富的经验、专业知识和洞察力，并在向卫生政策决策者协作和传播我们的工作方面有着良好的记录。

 DESCRIPTION (provided by applicant): Colorectal cancer (CRC) is the second leading cause of cancer death in the United States. The long-term goal of our proposed project is to reduce the population burden of CRC by providing the information needed to address key policy questions and prioritize future research. To accomplish this goal we will use our population- based microsimulation models to: 1) Inform emerging issues in health policy across the CRC-control spectrum; 2) Guide CRC research priorities and study design using a value of information (VOI) framework; and 3) Engage stakeholders, train modelers, and promote model transparency to ensure high-quality evaluation of CRC control measures, now and in the future. Our team will fill critical gaps in knowledge, enabling decision makers to act. Important gaps in knowledge include the impact of failures in screening and treatment processes on CRC burden; the potential to safely reduce screening and surveillance intensity among some patients based on currently available tools for risk-stratification; the potential benefit of new targeted screening approaches based on patient-level information (i.e., "precision medicine"); and the importance of clinical management of diminutive polyps. The three participating modeling groups are well-positioned to carry out this work, bringing a wealth of experience, expertise, and insight to issues related to microsimulation modeling of CRC, and have a proven track record of collaborating and disseminating our work to health policy decision makers.