WORKSHOP ON UNDERSTANDING PATHWAYS TO SUCCESSFUL AGING: BEHAVIORAL AND SOCIAL FACTORS RELATED TO ALZHEIMER'S DISEASE

本次提议的研讨会还旨在解决NIA在社会和行为科学方面的目标，这些目标与国家阿尔茨海默氏症计划的战略相一致，包括扩大旨在预防的研究，并与阿尔茨海默病研究实施里程碑相关的非药物干预。为此，BSR特别感兴趣的是了解潜在可改变的行为和社会风险因素如何影响晚年的认知状态和阿尔茨海默病（AD）。在将一系列行为和社会因素与认知健康联系起来的强有力的证据基础上，一些nia支持的工作已经在进行，以测试社会参与、认知刺激、饮食调整和减肥、锻炼、艺术和创造性活动以及减轻压力是否可以预防或补救正常的与年龄有关的认知衰退。现在人们也越来越有兴趣了解行为和社会过程的作用，无论是直接的还是通过与生物易感性的相互作用，在阿尔茨海默病的病因学中，并从长远来看，评估它们作为阿尔茨海默病预防目标的潜力。

This proposed workshop also aims to address NIA’s objectives in the social and behavioral sciences that are consistent with strategies in the National Alzheimer’s Plan, including to expand research aimed at prevention, and is relevant to the Alzheimer’s Disease Research Implementation Milestones related to non-pharmacological interventions. Towards this end, BSR is particularly interested in understanding how potentially modifiable behavioral and social risk factors affect later life in cognitive status and Alzheimer’s disease (AD). Building on a strong evidence base linking a range of behavioral and social factors to cognitive health, several NIA-supported efforts are already underway to test whether social engagement, cognitive stimulation, dietary modification and weight reduction, exercise, artistic and creative activities, and stress reduction can prevent or remediate normal age-related cognitive decline. There is now also growing interest in understanding the role of behavioral and social processes, whether direct or via interactions with biological susceptibilities, in the etiology of AD and, in the longer term, assessing their potential as targets for AD prevention.