WORKSHOP ON UNDERSTANDING PATHWAYS TO SUCCESSFUL AGING: BEHAVIORAL AND SOCIAL FACTORS RELATED TO ALZHEIMER'S DISEASE

这个拟议的研讨会还旨在解决NIA在社会和行为科学方面的目标，这些目标与国家阿尔茨海默氏症计划中的战略一致，包括扩大旨在预防的研究，并与与非药物干预相关的阿尔茨海默病研究实施里程碑相关。为此，BSR特别感兴趣的是了解潜在的可改变的行为和社会风险因素如何影响认知状态和阿尔茨海默病(AD)的晚年生活。基于将一系列行为和社会因素与认知健康联系起来的强有力的证据基础，NIA支持的几项努力已经在进行，以测试社会参与、认知刺激、饮食调整和减肥、锻炼、艺术和创造性活动以及压力减轻是否可以防止或补救正常的年龄相关认知下降。现在，人们越来越有兴趣了解行为和社会过程在阿尔茨海默病病因中的作用，无论是直接的还是通过与生物易感性的相互作用，并从长远来看，评估它们作为预防阿尔茨海默病目标的潜力。

This proposed workshop also aims to address NIA’s objectives in the social and behavioral sciences that are consistent with strategies in the National Alzheimer’s Plan, including to expand research aimed at prevention, and is relevant to the Alzheimer’s Disease Research Implementation Milestones related to non-pharmacological interventions. Towards this end, BSR is particularly interested in understanding how potentially modifiable behavioral and social risk factors affect later life in cognitive status and Alzheimer’s disease (AD). Building on a strong evidence base linking a range of behavioral and social factors to cognitive health, several NIA-supported efforts are already underway to test whether social engagement, cognitive stimulation, dietary modification and weight reduction, exercise, artistic and creative activities, and stress reduction can prevent or remediate normal age-related cognitive decline. There is now also growing interest in understanding the role of behavioral and social processes, whether direct or via interactions with biological susceptibilities, in the etiology of AD and, in the longer term, assessing their potential as targets for AD prevention.